Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 7.9e-14 2.9e-10 42.6 0.1 9 74 10 73 5 76 0.93

2 2 7.1 2.6e+04 -2.1 0.0 6 22 150 166 147 167 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	7.9e-14	2.9e-10	42.6	0.1	9	74	10	73	5	76	0.93
2	2	7.1	2.6e+04	-2.1	0.0	6	22	150	166	147	167	0.81

Coding Sequence: ATGGATTATTCTTTACaatcaaaaaaattatgtattccAAAAGGTTGGAGTAGGGAGGAGGTAGTAAGAAAATGTGGGATTTCTAAAGGAAAAGTGGATATTTATATTAGATCTCTAGGTGGAAAACTTTTTCGTTCGAAGAAGGAATTGGAAAATTACATTGTTGAGAAATGTCTGTCTGTAGACATAAATGCATTTAAATTCGGTACCAGAAagcaaaacaaaactaattgTTCTATGATTTTTAATGACAGTTCCACTCAAGCACTAAATACTACTTCCCTGGATAGTAATAACACCAGTTCTACCCCTTCAAAGCAGTCATCTGAAGAGAGTTTGAATGTTTCCAACAGAAGTGTATATTCAGAAAGTTCAACAGCAGAAAAACCTTCCTTAAATTTTGTTGGGAACCACGTAATTGGTAACCAAACAAATAGCATCTCCACCAATTGTCTCTCCATGTTAAACTTGGACTGGATAAGTGATGAGTCAATTCgtatttattttgaattgctATCCACAAAAGTGATTAACAACAATGATATTCATCTAATGAATCCGATCATTGCTCAGGCATTAAAGTGTGTGACGGACACAGATCACATTATCCAACCCCTGACCTAG
Protein Sequence: MDYSLQSKKLCIPKGWSREEVVRKCGISKGKVDIYIRSLGGKLFRSKKELENYIVEKCLSVDINAFKFGTRKQNKTNCSMIFNDSSTQALNTTSLDSNNTSSTPSKQSSEESLNVSNRSVYSESSTAEKPSLNFVGNHVIGNQTNSISTNCLSMLNLDWISDESIRIYFELLSTKVINNNDIHLMNPIIAQALKCVTDTDHIIQPLT

Sequence clustering based on sequence similarity using MMseqs2