Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 5.2e-26 1.1e-23 84.8 0.1 7 109 42 138 37 139 0.93

2 4 0.21 45 5.6 0.0 80 106 141 167 137 170 0.88

3 4 5.2e-17 1.1e-14 55.8 0.0 33 109 217 292 216 293 0.93

4 4 3.6 7.6e+02 1.6 0.1 81 109 296 324 291 325 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	5.2e-26	1.1e-23	84.8	0.1	7	109	42	138	37	139	0.93
2	4	0.21	45	5.6	0.0	80	106	141	167	137	170	0.88
3	4	5.2e-17	1.1e-14	55.8	0.0	33	109	217	292	216	293	0.93
4	4	3.6	7.6e+02	1.6	0.1	81	109	296	324	291	325	0.87

Coding Sequence: atgaatattattaaaGGTCCTTTAATAATATTCTGTACCTTATATTGTATAGAAAGATCTAAATCACAAAAAGAGTTGGTATTATTATACAATCTAGAATATTCGTTGGTGGGGAAATTCGGAAATACAGAATATTCTGATGTAACATTTTTAGTTTCTGGAGAAGAATTTCGTGTTCATAGATTCATTTTAGCAGCACGAtctttagtatttaaaaaaatgtttgaagatGAAGCAAAAAAACATATATTTCCTATAGATGGTATTACTCCTGAGGTATTTAAACAAATCTTACATTTCATTTATACTGGATACGTAATTTCGGATAAAATATCGTATGAATTGTTAGAAAGTGCTCATAATTTTGGATTAAATCGGTTAAAAGTAATGTGTGCAAGAAAATTGTGTTCCAAGGCATCAACTGAAAACGTTTGCGATTTACTGATTTTTGCTgataaatataatataccaaATTTGAAGACCAAAATACTGAACTTTATTAACTTGGATGCTAAAGAAGTAGTTAAAACAAAAAGTTGGGAAGAGATAAAAACATCCActgatttattaaaacaaataaatgaagCTATTTTATTAGAACATACATTCTGGAAAGAAATATCTCCATTAATTAATGATGAGCCAATTCGAAGCCCAGTCTTTCAAGCAATGTTCAAACATGATATGGAAGAGACTAGGAATAATGAAGCGGTTATAAAAGACATAAATCCCGAAGTGTTTGGAGAAATGTTGAAATACATTTATACAGGAAGTGTTTCAAATATAGATAAAATAGCTCCAGAGTTGATATTTGCTGCAGACAAGTACGACTTGGAACCGTTAAAACGTATTTGCTTACAAAATATGATTAATAAATTATCAATCAACACTGTCAGCGAAACACTGTTATCAGCAGATGCCCTTAATTTAACAGAATTAAAACATTCAGCTATTGAATATATAAAGAAGAATCTTAAAGAAGTCATGAAAGAAGATAGTTGGAAATCCATTCTAGATACTCATCCAACTTTGGTGTCGGAGATATGCGAGGCTATAGtattggaataa
Protein Sequence: MNIIKGPLIIFCTLYCIERSKSQKELVLLYNLEYSLVGKFGNTEYSDVTFLVSGEEFRVHRFILAARSLVFKKMFEDEAKKHIFPIDGITPEVFKQILHFIYTGYVISDKISYELLESAHNFGLNRLKVMCARKLCSKASTENVCDLLIFADKYNIPNLKTKILNFINLDAKEVVKTKSWEEIKTSTDLLKQINEAILLEHTFWKEISPLINDEPIRSPVFQAMFKHDMEETRNNEAVIKDINPEVFGEMLKYIYTGSVSNIDKIAPELIFAADKYDLEPLKRICLQNMINKLSINTVSETLLSADALNLTELKHSAIEYIKKNLKEVMKEDSWKSILDTHPTLVSEICEAIVLE

Sequence clustering based on sequence similarity using MMseqs2