Smel044249.1
Basic Information
- Insect
- Stenurella melanura
- Gene Symbol
- HCM1
- Assembly
- GCA_963583905.1
- Location
- OY757313.1:77442637-77463680[-]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 9.8e-17 4e-13 51.5 0.3 34 85 3 51 1 55 0.90 2 2 1.4 5.6e+03 -0.2 0.1 44 66 51 73 47 82 0.55
Sequence Information
- Coding Sequence
- ATGGGAGATCATTTCCCCTTTTATAAGCAGAATGATGACAGGTGGAAAAATTCCGTAAGGCACAATTTATCAATTAATCCACATTTTCGAAAAGGTGGTAAGGCAGTTCAAGGTGCTGGACATCTTTGGACCATTGCCCAACGAGATGATAAGAAATCCTGGCAAATTaaacagAGGATGAACCAATTTATTCAAAGTATCTACAAAGACACGAAAACTCAAGAACAGGAAGCCTTCGACAAAGAACTGCAAGCTGCAACTGAAAGCATTTTGGGTGAAATCGACAGTCATAATAAAAATGAGCCGGGAACAGTATCTAGAGGGAGTAGTAATATTGAAGTTGAATATATTAATCTAGCTGAAGCTCCCAATGGATTAGAAGATTTCCTATCTCCTCCCGTCTCGAAGCAAGAAATTGTAAACGAATGTGGTTTGGGAAGCGACTTTTTCATCACGGACATAAATCCCAATGCTCTGGGTTTAAATTTGACCGAAGCCGAAGCAATAACCGAGGATGGAATTTATGAAGACATGACTTTTGAGTATTACGAACTAAAAGAATAA
- Protein Sequence
- MGDHFPFYKQNDDRWKNSVRHNLSINPHFRKGGKAVQGAGHLWTIAQRDDKKSWQIKQRMNQFIQSIYKDTKTQEQEAFDKELQAATESILGEIDSHNKNEPGTVSRGSSNIEVEYINLAEAPNGLEDFLSPPVSKQEIVNECGLGSDFFITDINPNALGLNLTEAEAITEDGIYEDMTFEYYELKE
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01014067; iTF_01289566;
- 90% Identity
- iTF_01289566; iTF_01014067;
- 80% Identity
- -