Sbip039926.1
Basic Information
- Insect
- Stenoptilia bipunctidactyla
- Gene Symbol
- -
- Assembly
- GCA_944452705.1
- Location
- CALYCB010001224.1:422125-425660[+]
Transcription Factor Domain
- TF Family
- POU
- Domain
- Homeobox|Pou
- PFAM
- PF00157
- TF Group
- Helix-turn-helix
- Description
- The POU domain is a bipartite domain composed of two subunits separated by a non-conserved region of 15-55 aa. The N-terminal subunit is known as the POU-specific (POUs) domain (this entry), while the C-terminal subunit is a homeobox domain (IPR001356). Both subdomains contain the structural motif 'helix-turn-helix', which directly associates with the two components of bipartite DNA binding sites, and both are required for high affinity sequence-specific DNA-binding. 3D structures of complexes including both POU subdomains bound to DNA are available. The domain may also be involved in protein-protein interactions [6]. The subdomains are connected by a flexible linker [7, 5, 8]. Despite of the lack of sequence homology, the tridimensional structure of POUs is similar to 3D structure of bacteriophage lambda repressor and other members of HTH_3 family [7, 5]. POU proteins are eukaryotic transcription factors containing a bipartite DNA binding domain referred to as the POU domain. The acronym POU (pronounced 'pow') is derived from the names of three mammalian transcription factors, the pituitary-specific Pit-1, the octamer-binding proteins Oct-1 and Oct-2, and the neural Unc-86 from Caenorhabditis elegans. POU domain genes have been identified in diverse organisms including nematodes, flies, amphibians, fish and mammals but have not been yet identified in plants and fungi. The various members of the POU family have a wide variety of functions, all of which are related to the function of the neuroendocrine system [4] and the development of an organism [1]. Some other genes are also regulated, including those for immunoglobulin light and heavy chains (Oct-2) [3, 2], and trophic hormone genes, such as those for prolactin and growth hormone (Pit-1).
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 27 0.12 9.2e+02 1.1 0.0 12 28 15 31 14 33 0.89 2 27 0.099 7.4e+02 1.4 0.0 12 28 29 45 27 52 0.89 3 27 0.032 2.4e+02 3.0 0.1 12 28 43 59 38 61 0.90 4 27 0.091 6.8e+02 1.6 0.0 12 28 57 73 49 79 0.90 5 27 0.099 7.4e+02 1.4 0.0 12 28 71 87 65 89 0.89 6 27 0.057 4.3e+02 2.2 0.1 13 28 86 101 80 112 0.66 7 27 0.025 1.8e+02 3.4 0.2 12 28 99 115 92 125 0.84 8 27 0.031 2.3e+02 3.1 0.1 12 28 113 129 107 131 0.90 9 27 0.067 5e+02 2.0 0.1 12 28 127 143 122 153 0.73 10 27 0.027 2e+02 3.3 0.1 12 28 141 157 136 166 0.89 11 27 0.031 2.3e+02 3.0 0.0 12 28 155 171 150 173 0.90 12 27 0.029 2.2e+02 3.2 0.1 12 28 169 185 159 188 0.89 13 27 0.092 6.8e+02 1.6 0.1 12 28 183 199 177 205 0.89 14 27 0.024 1.8e+02 3.4 0.1 12 28 197 213 186 222 0.89 15 27 0.024 1.8e+02 3.4 0.3 12 28 225 241 214 251 0.84 16 27 0.032 2.4e+02 3.0 0.1 12 28 239 255 237 261 0.90 17 27 0.027 2e+02 3.3 0.2 12 28 253 269 243 278 0.90 18 27 0.063 4.7e+02 2.1 0.1 13 28 268 283 266 294 0.60 19 27 0.024 1.8e+02 3.4 0.2 12 28 281 297 275 307 0.83 20 27 0.034 2.6e+02 2.9 0.1 12 28 295 311 293 314 0.90 21 27 0.084 6.3e+02 1.7 0.1 12 28 309 325 299 332 0.88 22 27 0.08 6e+02 1.7 0.1 12 28 323 339 316 348 0.87 23 27 0.03 2.3e+02 3.1 0.1 12 28 337 353 331 355 0.90 24 27 0.087 6.5e+02 1.6 0.0 12 28 351 367 343 376 0.90 25 27 0.1 7.7e+02 1.4 0.0 12 28 365 381 360 383 0.90 26 27 0.033 2.5e+02 3.0 0.1 12 28 379 395 375 397 0.90 27 27 0.03 2.2e+02 3.1 0.1 12 28 407 423 400 425 0.89
Sequence Information
- Coding Sequence
- ATGATTTTACAGTACCAAAACATCACATTACCAGAAGAAGGCACGTTCAAGGACAACAGGCCCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGCCCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGCCCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGCCCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGCCCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGCCCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGCCCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGCCCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGCCCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGCCCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGCCCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGCCCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGCCCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGACCACTATAAACTTGACTCAGGGCACGTTCAAGGACAACAGGCCCACTGTAAACTTATATGACTCAGGGCACGTTCAAGGACAAACAGGCCCACTATAA
- Protein Sequence
- MILQYQNITLPEEGTFKDNRPTINLTQGTFKDNRPTINLTQGTFKDNRTTINLTQGTFKDNRPTINLTQGTFKDNRPTINLTQGTFKDNRPTINLTQGTFKDNRTTINLTQGTFKDNRTTINLTQGTFKDNRPTINLTQGTFKDNRTTINLTQGTFKDNRTTINLTQGTFKDNRTTINLTQGTFKDNRPTINLTQGTFKDNRTTINLTQGTFKDNRTTINLTQGTFKDNRTTINLTQGTFKDNRTTINLTQGTFKDNRTTINLTQGTFKDNRPTINLTQGTFKDNRTTINLTQGTFKDNRTTINLTQGTFKDNRPTINLTQGTFKDNRPTINLTQGTFKDNRTTINLTQGTFKDNRPTINLTQGTFKDNRPTINLTQGTFKDNRTTINLTQGTFKDNRPTINLTQGTFKDNRTTINLTQGTFKDNRPTVNLYDSGHVQGQTGPL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -