Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_008973525.1
Location
Contig042:725290-730272[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.5e-09 4.5e-06 25.9 0.1 5 48 584 627 580 656 0.88
2 2 0.75 2.2e+03 -1.9 0.0 35 48 700 713 698 716 0.78

Sequence Information

Coding Sequence
ATGCCGTCAAATGATAAAATAAATATTAAGGACGACATTAGAGAAGATATTTGGTCGACTCAACGTAATTTAACTGGAATTCAAAATTATTTATCACAGCCTGATAAAAATATGAATGTTTCAATGAAGGAAAAAGGGACTAATTCTCACAATGAAATACTCAAAGCAATGATTTCCACTCCTATGAAACCCATGATAAAACCTCGCGTTAAATTGCCCGTAGGACAATCAAGCCCTTCCAAAACAAAACATCCTATCCCAACAAAACGAAAAATCAACAAAAACAGAAAAATTCTTAATTCTAATTTGAGTGCTGAAGAAAATGCACCAAATGTTTCCCTAAAATCTGAAAAAGGTCTCTTAGTTCAAGGATCACGGGTAGAAGCTAAAGATTTTAATGGAAAATGGAGTCTAGCTTGTGTTATAGAAATTAGTCCCATTGACCAAGAAGTACTCATTCATTATGATAACTGGTCTCAACGCTTCGATGAATGGATTAGTATGGGGAGTTCACGCCTTCGTTTAGTTGAAAGTCCGCCACCTACAGCTTCGGTGACACCGCCAGTTTATAAAATAGGAGAACGTTGTTTAGCACGATGGTCTAATAACCAAAGATTTCCAGCCACAGTGAATAAAGTTCTACAGAATGGAAAATATGAAGTAATGTTTGACGATGGTTTCACTCGTACGATGAAATGGGTCATGATGTCCAAAATAAAAAAGGCTTCTCACCGTCGAATATCTGCGGCTTCTTCACCTAATGCACTCTCACCTGTGCCTTATGGAGCGAGACGAGATGCCACTGTTGCAGTTGCTCCTCAAGCGACTCCACCTCCCCCATTACATAATCACTTATTTGATTCAAACCGTGATCATTTAGGAACTAAAGAAGAAAGGAAAGCTATGGAACAACATTTAAATGATAAAGAATTATATTTTGTCCAAAAGAAAAGAAAAGATGTGGATAAACAGGTTGATGGAAAAAAGCCTTTGGATGAAAATGATGGAAGGCGGAGAAAGAGGAAATTAAAAACACTTGATGAAGAAGATCTTAAAAATAACATAGGTAAAAAAAGAATCAAAAGAAAATTGAAGAATATCTCAAATAAAACTCCAACTGCCAGTACTGATGTGTCGGAAGTCGTTAAACCTATTAAATCAGATTCAACTGTGAAATCTGTTTCTAGTCCCATACCTAACACTGTGCCAGATAATAATTTAAATAAGACTAGTACAAAATCTAAATCATCAGCCCAACATACTACAAATGTTTGTAAAACGTCTCCAGCAATAACAAACAACCCAATGATTTCTAAACACAGCTCGAGTTCTAAAACTGCCACGCACAACACTTCTGAAACCCCAGTCGTAGAAAACGCTACTGAATCTGTATCGTCACAGGCTACGTCTACAATTTCGTCTCCAAATCCTCAAATAAAAACTGAAAATGCTCCAGAACCAACACCTCTTGTTTCAAATAGTGCTATTTCAAATGCTTCATCTAACAGTATTAAAAAAGCTTTATTAAATACTAACCCCAGTTCACCGGTTACACATTCAGAATATTTACCAAACCCAACTCCATCTGTACCAAATTTGAAAACATCGATTGAAAAACCATGCATTGAACCACAATTATTCCGAGCTGCCGAAGAGGACTGGTGTTGTCATTGGATAAACGGTCAACCGGTGGGTACCATTTTAGATTCTGAACCTAACAAGGATTCATCTGCTAGTCGGGTGACTGTACAAGTGGAGGATTCTAGATTACCGCCTAAATGGACCAAGCTTTTGACGAGAAGAACATTTGGGAAGACCGAAGGGAAATGGGATGTCGTTTTGGTTTGTCCTAGTGGTCGTCGTTATCGCACAAAGGGTAAAATGCAGGAACGTTTAAATGAACCAGATCATGACGAACTTGTTCCTTATGCTCTGGGATTGATGGATTTTAGTACCCATCGTAAACAAGCTAGACAACTAGGATGGGATACTGCTATGCCTAATTCGAATAAATCACCTGAACCAGTTATAGCTCAAAATAATATTAATGGACAGATTTTACCTAGTACTTTTACATCGGCTCTGTCAACGGAATGTTTTTCAAAACCTTGTGGAAGAAAATTTGTTTGTATCAACTCTTTGAAAGTGGAAATCATTGGTAACCTTTTACGTTGTCCGAAAGAAGGCTGTTTAAAAAAATTCCGCAAAGAAACTGTTATACAAATGCATATAAAGCATTATCATCCCGAATTGTGGCCTAATGTAGCAGATTTGGCGCATACTAGAATTGTCATTGAAGAACCACCAGCGTCAGTTATTAAACCGAAAGAATTGACTGATAGAACCCCAGGCAAGCCGAGAGACAGAAAGCTTTTTGAATATGTTGATGTTCCTATCAAAACGGAGCCTATGGATTCAGATGATAATAGTTTTTATTCTAATACAACTGCTTCACATTTGGAAGATAGAAATCATCATGACGAATTCCCTAAACCGAATTTTATTTCCATCAAACAAGAAATTCTTTCACCTGAAAATAAAAAGTATTCTAATGAAGATGAATATTATCTTAATGAAACTGTATGTAAATCGAATAATGATTCAAAAATTATAGATCCATTTTCAAATGTGCATCCTAAATATGTAAGTGAAACTAGCAGTCAGCCATCTGAAGTGTATTTGCCCGATGATGAATACTTGCCTAAAAAAGAAGTCAATCAAAATTTCAAGAAAGGATATAATTATAGTGCTTATAGATACAATAGTCTGGTCCCAGAAAGGCATAAAGATTCGGAAGCTGCAGAGAAATATAGCCTGAAGAAAAAGAAAATTCCAAAACATTCAGAAGTGAGCAAGTATGAAGCGACCCGATCAAATAATGCATACTCAAATTCTTGTTATAGCATTGAACAACGTGTGCAAATCATCAAATTTTATTTTCAAAACCGGTGCTCCGTTCGAGAAACGTTCTGCGCATTTCGTGATTCCTATCCACGCCACAAACGTCTTGCCGAGTCGACTATTCGACGCTTGGTGGCCAAATTCGAATCGACCGGCTCAGTAAACAATCAGCCAACACCCACACGTTACCGAAATGCAAGGTGTGCCGAAAACATCGCTGCTGTGCGCAAGAGCCTACGGGATAACCCAACGCAGTCAATTTCTCATCGTTCGCAAGAACTTGGCCTTTCTGCGACTTCAATTTGGCGGATTTTGCGCCGAGACTTGTTAACATTTCCGGTATCTTAA
Protein Sequence
MPSNDKINIKDDIREDIWSTQRNLTGIQNYLSQPDKNMNVSMKEKGTNSHNEILKAMISTPMKPMIKPRVKLPVGQSSPSKTKHPIPTKRKINKNRKILNSNLSAEENAPNVSLKSEKGLLVQGSRVEAKDFNGKWSLACVIEISPIDQEVLIHYDNWSQRFDEWISMGSSRLRLVESPPPTASVTPPVYKIGERCLARWSNNQRFPATVNKVLQNGKYEVMFDDGFTRTMKWVMMSKIKKASHRRISAASSPNALSPVPYGARRDATVAVAPQATPPPPLHNHLFDSNRDHLGTKEERKAMEQHLNDKELYFVQKKRKDVDKQVDGKKPLDENDGRRRKRKLKTLDEEDLKNNIGKKRIKRKLKNISNKTPTASTDVSEVVKPIKSDSTVKSVSSPIPNTVPDNNLNKTSTKSKSSAQHTTNVCKTSPAITNNPMISKHSSSSKTATHNTSETPVVENATESVSSQATSTISSPNPQIKTENAPEPTPLVSNSAISNASSNSIKKALLNTNPSSPVTHSEYLPNPTPSVPNLKTSIEKPCIEPQLFRAAEEDWCCHWINGQPVGTILDSEPNKDSSASRVTVQVEDSRLPPKWTKLLTRRTFGKTEGKWDVVLVCPSGRRYRTKGKMQERLNEPDHDELVPYALGLMDFSTHRKQARQLGWDTAMPNSNKSPEPVIAQNNINGQILPSTFTSALSTECFSKPCGRKFVCINSLKVEIIGNLLRCPKEGCLKKFRKETVIQMHIKHYHPELWPNVADLAHTRIVIEEPPASVIKPKELTDRTPGKPRDRKLFEYVDVPIKTEPMDSDDNSFYSNTTASHLEDRNHHDEFPKPNFISIKQEILSPENKKYSNEDEYYLNETVCKSNNDSKIIDPFSNVHPKYVSETSSQPSEVYLPDDEYLPKKEVNQNFKKGYNYSAYRYNSLVPERHKDSEAAEKYSLKKKKIPKHSEVSKYEATRSNNAYSNSCYSIEQRVQIIKFYFQNRCSVRETFCAFRDSYPRHKRLAESTIRRLVAKFESTGSVNNQPTPTRYRNARCAENIAAVRKSLRDNPTQSISHRSQELGLSATSIWRILRRDLLTFPVS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-