Basic Information

Insect: Stegana nigrithorax
Gene Symbol: MBD-R2
Assembly: GCA_037044495.1
Location: JBAMBQ010003091.1:407861-411640[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.1e-21 1e-17 63.6 0.1 4 76 424 494 421 495 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.1e-21	1e-17	63.6	0.1	4	76	424	494	421	495	0.93

Sequence Information

Coding Sequence: ATGGGCCGTCGATGCTGCATTGCTGGCTGCCAGTCGACCTCACGCCTGCCGGAACACCATGGCGTGACCTATCACTCCTTTCCCACGGACAACGCCATACGCTCCATTTGGATTAAGAACACGCGCATCAGCCAGGATCGACATATAACGAAGAGCGTTTTGGTCTGTTCGCGACACTTTCGACGCAACGACTTTCAGCCCATACGCAATGGCAAATACTTACTCAAAGCAGGCGTGTTCCCCACCGTTTTTCCATGGGGTAAGCTGGATCAAGCGCAGGTTGAGGCTGACCAAGAAGCGCTTAAAAATGCCACAGTGGATGTTTCTGCAGTAATCGGAGGAACTGCAAATAACTCAGCAGAAGACATAACGAAAGCAACTGTGGCCGCGACCGTAGCACAAATACTTGCTGAGACAGCCGAACTTAAAGCATCGGTGACTACTGCAGCGGCAAGACCCACGACGCCTAGCAATGCTGAGGCTATAAACACGAGCTCAAATCGCGGTTCGCCCGCGGTGACGAACACGCCGTCAGCCGGGGGCAAGTATGAGCCAGCCACTTACTTCGGAGTGGGCGCACGTTTTCAGGCACAGCGCAGCGATGGGCAATGGTACATCGCACGCGTGCTGGAGGTCAGTGACGACAATGAAGAGGTGTTGGTGCGCTACGAGCGCAACAGTAAGAATAAAATGACGCACGACCTTAAGCCGGAGTGGATAAGCAAAAAGAATTGTCGACAGCGCGTGAATCCGCGTGGTATGCCAGTCTTTGCGCTCGAGGAGCGTTGTTTGGCACGTTGGTCGGGTCCGCATAAGTTTCCTGGAACTATAAAGCAACTGCTCGAGAATGACACTTATGAGGTGCTCTTCGATGATGGTTACACCAAGAACGTGCGTGCAGTGCATATGAAAAAGATCGTCACTGAGTCGGCACCGGCGGCTGGTTTCGAGACGATTGTGGGTGCTGGAAGCGGCTTGGGTGAAGGTAGCACTGCCAGCATTTCGCCCTTAACGGTGACAAATCCCACAACACCGGTGCCAGGCGCGAAGACCAGTAAGTTAGCCGACACAtccggcaacaacagcaagaagcgAGCGACGGTTAGTCAACGCAAGGATTGGCCCCTGTTGGATATGGCTAATTTGGATTTGGCTTCACTTAATTTGCCGGAAATCCCACGTGACGGCGAGTGGACATGCCACTGGGTAAACGATCAGCCCATCGGCACTGAGGGCTTCCTCATTGTGGGCGAACACCGCAAACCCACAGTTGTCGTAGAGGATTGGCGTTTGCCAGAAGGTTGGGTGAAACATATGTACCAGCGTTCGAATGTGCTGGGCAAGTGGGATGTCATTCTCGTCTCGCCCACTGGCAAACGTTTTCGTTCCAAATCGGATCTAAAGGTTTTCCTCGAAGATCAGGGGCTAACCTACAACCCGGATATTTACGATTTTAGCATACACAGGCGACGTGCCAAGGACATCAATGCTTATGTCTTCACGCCTGAATATAAACCACAACAGCCCCCAAAACCCAAAGCTTTGGAGCTTTCAACGCTGGACGCAACACTTGAAGATGCTAAGCTACCTTTAAATGCGTGCACGTCCACACCCTTAACAACGGGCGCCAGCAGCCAGTACATGGCCCCTCCCGTGGCAACTCCCATGCCGCCCATGGAACTCATGTCGCCGCAGGCTTCGGAGCAGTCAATGAGCACAGCTAATGCTGGTGATGGCAACACTGTGGGCTCGCCCCTAAAGATGGAAGGAGGTTATGCTTACATTGGCGGCCTAAAGGTACAAATTGTGGATAATCTCTTTCGTTGTCCGGAGGGCGGATGCGCTAAAAATTTTCGCAAAGAGGATCATGTGCTAATACATGTCAAACACTATCACAAAGACATGGCTAAATTACTAAGCGATTGTCCCAAGATGCAAGAGCTGGCTGTTAAGCGCACACATCCCACGTCCATCGAGCAACACGAGCCGCATCCCAGGAATCAAATACCCAATCAGCAATTCTTTGCTAAGCTGCACCAACAAGATTTACAGCAGTCGCGTTCATTCCGTCGCAATGCCGCTGCTCCAACTCCAACGCCGCAGTCAACGTCCACTACGCCAATCGCAACAAGCAGCGCATCCACACCCAATGTGCAGACTACTGAGCGTATGGATATTGCGCCCGATTCGCCAAATATAGCGGGTACTCCAAAGAGCGGCAGCTCCGACCATTCCCAGGACGCCAACACCACGAACACTAATAACAGCTTTGTGGATGTCGTAACTACGCCGGTAGGGGGGGCTAGCGCCGCTGAAAGTCTCTccacaaatgcaaagcaatcgAAGCGGCCGCGTTTCTCACCCACAAAGCGTCCTTTGGGCTCACGCAAAAGCAATCGTCAGCGCACGACGCGTCGCTATTTGACCGCTGCTCAGGCAACATCTGCGCCCAGTCATCGCGTGTCGCAATTGGCTGTCGTTGGAGAAATCAGTTTGGCTGCCTCAGATTTCGAAGAGACACGGCAATCTTTTAATGCCACGCCCGATGCGCGAGTAAGTGAACCGAAGAAGCGACGTGTTGCCGCAACACCGGCCAGCTCTGTTGAATCGCCTGCCACCGGTGATTCGTCCACGGCTAATTCGAATGAACCGCAGGAGCATGGCTCGGGATCCCATGCCGCACTGCCAAAGACTGCAGCACCGCAGTATATCAAGGAAAATGGCGAACTCATAAAGATTGTGCGCATGCGGCAAGAGGAGATAATCAATTGCATTTGCGGCTATGGCGAAGAGGACGGCCTGATGATACAGTGTGAACTATGCCTGTGCTGGCAGCATGGTGCCTGCAATGGTATTGTCAAGGAATCTGATGTTCCGGACAAGTATGTCTGTTTCATTTGTCGCAATCCGCCGCGTGGGCGTGATTCGATGCGCTTTAAACATGATCAGGATTGGCTATACGAGGGCAAGTTGCCCGTGGCGAATTACCATATGAGTAATCCCAATGTGGGCAAGACGTTCGAGTTTCTTAAAAAGTCACATACGCTGACTGGCAACCTCATCGAGACGAAACGTTTCCTGCACTCGTTGCGAGTTAAAATCAACATTGCGCACAACCGAGTACATCCCAAACTGTACCTTTGGGCAAAGAAGTGGGATGACGATGAGGTTGCGGATGTGAAGCCAAATGCACAACTATCAATTTCACCAATGAAGCGTGCGAAGCAGACGGAGTCGCCAAATATGCCACATGTGCCGCAGCCGGAAGCAGCTATTGATCCAGAAGAATGCCAGGTGCGATTGATTGAGCACGTTAAAGTCCAGCAGGATAAAGCCTGGCAGCGTCTAGATGCTATTGAAGCTGAAATGGATGCGCTTGAGCGTGCAGATGAATTATCCGATCTGAAGGACACTGATATATCGGTGACCAAAGAGGCTTTGGCTGCTTACATTAAGGAGTTGGAGACAATGCGCTATATAGCTAAAGTGAATACAATAGCTAATACTAAGGAGACCAATAAAGCGTCGGAATAA
Protein Sequence: MGRRCCIAGCQSTSRLPEHHGVTYHSFPTDNAIRSIWIKNTRISQDRHITKSVLVCSRHFRRNDFQPIRNGKYLLKAGVFPTVFPWGKLDQAQVEADQEALKNATVDVSAVIGGTANNSAEDITKATVAATVAQILAETAELKASVTTAAARPTTPSNAEAINTSSNRGSPAVTNTPSAGGKYEPATYFGVGARFQAQRSDGQWYIARVLEVSDDNEEVLVRYERNSKNKMTHDLKPEWISKKNCRQRVNPRGMPVFALEERCLARWSGPHKFPGTIKQLLENDTYEVLFDDGYTKNVRAVHMKKIVTESAPAAGFETIVGAGSGLGEGSTASISPLTVTNPTTPVPGAKTSKLADTSGNNSKKRATVSQRKDWPLLDMANLDLASLNLPEIPRDGEWTCHWVNDQPIGTEGFLIVGEHRKPTVVVEDWRLPEGWVKHMYQRSNVLGKWDVILVSPTGKRFRSKSDLKVFLEDQGLTYNPDIYDFSIHRRRAKDINAYVFTPEYKPQQPPKPKALELSTLDATLEDAKLPLNACTSTPLTTGASSQYMAPPVATPMPPMELMSPQASEQSMSTANAGDGNTVGSPLKMEGGYAYIGGLKVQIVDNLFRCPEGGCAKNFRKEDHVLIHVKHYHKDMAKLLSDCPKMQELAVKRTHPTSIEQHEPHPRNQIPNQQFFAKLHQQDLQQSRSFRRNAAAPTPTPQSTSTTPIATSSASTPNVQTTERMDIAPDSPNIAGTPKSGSSDHSQDANTTNTNNSFVDVVTTPVGGASAAESLSTNAKQSKRPRFSPTKRPLGSRKSNRQRTTRRYLTAAQATSAPSHRVSQLAVVGEISLAASDFEETRQSFNATPDARVSEPKKRRVAATPASSVESPATGDSSTANSNEPQEHGSGSHAALPKTAAPQYIKENGELIKIVRMRQEEIINCICGYGEEDGLMIQCELCLCWQHGACNGIVKESDVPDKYVCFICRNPPRGRDSMRFKHDQDWLYEGKLPVANYHMSNPNVGKTFEFLKKSHTLTGNLIETKRFLHSLRVKINIAHNRVHPKLYLWAKKWDDDEVADVKPNAQLSISPMKRAKQTESPNMPHVPQPEAAIDPEECQVRLIEHVKVQQDKAWQRLDAIEAEMDALERADELSDLKDTDISVTKEALAAYIKELETMRYIAKVNTIANTKETNKASE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01363978;
90% Identity: iTF_01363978;
80% Identity: iTF_01363978;