Stae037009.1
Basic Information
- Insect
- Sphaerophoria taeniata
- Gene Symbol
- gsb-n
- Assembly
- GCA_943591125.1
- Location
- CALSBT010000769.1:3014615-3050603[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 3.5e-70 8.7e-67 224.0 1.4 1 125 22 143 22 143 0.99
Sequence Information
- Coding Sequence
- ATGGACATGACAAGTGCAAACTCATTGAACATGCGCCCGATATTTGCTGGATACCCATTTCAAGGACAAGGCCGGGTCAATCAACTCGGTGGGGTTTTCATCAACGGGCGGCCGCTTCCGAATCACATTCGTCTTAAGATTGTCGAAATGGCTGCGTCGGGAATTAGACCTTGTGTAATAAGTCGCCAATTGAGGGTGTCCCATGGATGTGTATCGAAAATACTTAATCGATATCAAGAAACTGGATCAATAAGGCCGGGTGTAATCGGAGGCTCCAAGCCAAAGGTAACATCGCCCGAAATTGAAATAAGAATTGAAGAATTGCGGAAAGCGAATCCGGGAATATTTAGTTGGGAGATACGGGAGAAACTGATTAAGGAAGGAATATCCGATCCCCCATCAACATCATCAATAAGTCGCCTGCTCCGTGGTTCAGATCGCACCATTGACGATGGACGGAAAGACTACAGCATCCATGGGATATTAGGTGGACGTGGCTCTGATTCCAGTGATACTGAATCCGAACCTGGAATCCCGCTGAAGCGTAAACAAcgcagatctcgaaccacgttcactgccgaacaattggaagctctcgaacgagccttctcgcgaactcaataccctgacgtctataccagagaggaactcgcccaatcgaccggccttactgaagcccgaatacaagtctggttcagcaacagaagagcccgcctgcgaaaacaTTCCGGCTCAAGTGGCGGCCTATCCGGAATGAACTCAAGCTTAGGTTTTGGTGGCATTCCAGTGTCATCGATGTCCGGCTATACCCCAGCCACCCAATCCATCCCTGGCAACGAAGCCCATCATCATCATCACCATCAGATGAGCAGTTACGACTTGATGGCCCAGTCACAGCATGGTTTTGCCTCGAGTTTCCAACATGCTCATTTTCCAGCTCAAAATTACTATCATCAAGATTACTCAAAAATGACCATGGACGATTTCAGCAAAATAACCGCCGAAAGTGTTTCCAAAATGTCACCATCCATACACTTGACTGATAATTATCCAAAAATTGAGGCTCCAACGAATTGGACACCATCCGCGGCAGCGGCCGCCTATCATTTGAACCAATCGACAGCCGCTTCGGTGGCGGCCGGTTACAATCATGCGACAGCGGTGAATGATTATTCTGCGACGACGGTACATGGCAATCAATTGAATACAGCAGCAGTTCCGACGGCCGGATATCAACATCCACTTCCGGTGCAAGGACAATCAAAATATTGGGCGTGA
- Protein Sequence
- MDMTSANSLNMRPIFAGYPFQGQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGIRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPKVTSPEIEIRIEELRKANPGIFSWEIREKLIKEGISDPPSTSSISRLLRGSDRTIDDGRKDYSIHGILGGRGSDSSDTESEPGIPLKRKQRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQSTGLTEARIQVWFSNRRARLRKHSGSSGGLSGMNSSLGFGGIPVSSMSGYTPATQSIPGNEAHHHHHHQMSSYDLMAQSQHGFASSFQHAHFPAQNYYHQDYSKMTMDDFSKITAESVSKMSPSIHLTDNYPKIEAPTNWTPSAAAAAYHLNQSTAASVAAGYNHATAVNDYSATTVHGNQLNTAAVPTAGYQHPLPVQGQSKYWA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00974622;
- 90% Identity
- iTF_01356693; iTF_00665591; iTF_00665477; iTF_01211739; iTF_01211896; iTF_00694582; iTF_00693770; iTF_00693618; iTF_00694428; iTF_00664796; iTF_00664688; iTF_00974622; iTF_00974481;
- 80% Identity
- iTF_01356693;