Basic Information

Gene Symbol
topi
Assembly
GCA_016802725.1
Location
NC:32489240-32492443[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.003 0.27 11.5 2.0 1 23 243 265 243 265 0.95
2 16 0.086 7.5 6.9 1.1 2 23 272 294 271 294 0.95
3 16 0.0024 0.21 11.8 0.2 2 21 301 320 300 321 0.92
4 16 0.00035 0.031 14.4 1.0 1 23 328 350 328 350 0.96
5 16 7.6e-07 6.7e-05 22.8 2.2 1 23 356 378 356 378 0.98
6 16 0.0044 0.39 10.9 0.2 2 23 390 412 389 412 0.94
7 16 0.015 1.3 9.3 6.5 1 21 428 448 428 450 0.95
8 16 2.6 2.3e+02 2.2 0.2 1 23 456 478 456 478 0.90
9 16 0.24 21 5.5 1.1 1 23 488 511 488 511 0.92
10 16 0.0089 0.79 10.0 0.0 1 21 525 545 525 546 0.92
11 16 0.0033 0.29 11.3 0.1 1 23 551 573 551 573 0.98
12 16 1.5e-06 0.00013 21.9 3.1 1 23 579 601 579 601 0.98
13 16 0.0001 0.009 16.1 0.2 1 23 607 630 607 630 0.97
14 16 0.036 3.2 8.1 0.7 1 23 636 658 636 658 0.89
15 16 2.4e-07 2.1e-05 24.4 2.2 1 23 664 686 664 686 0.99
16 16 6.4e-06 0.00056 19.9 6.3 1 23 692 715 692 715 0.97

Sequence Information

Coding Sequence
ATGTCAAAGCCAGAATCAATTAGTACCTTAAGTGATCATGAAGATGATATTGACAATTTGGATGGTTCTATGCTATGGTCTCAAGAGGAGCCACTTTCTTCTAACGAAATATTAGAATTATCGGCGCaagatgaaaaagaaaacagcttattttctttttgtcgaTTATGTGCTGGTCAAACCACTAATCCAATATATATCTATTCGGAATTTGGAGAATCAATGAAACTGgcacataaaataaatacatgctTAAGTGTtaagATTAAGAAGACAGACCCATTGCCAAAGCAGCTTTGTTCGACATGTGTTGAGAAAGTAAACTGGTATGACAAATTTGATGCACAATGCATTAAAGCAGAGGAAATTCTGTCAACAATGCTAAAGGAAAAGCAgtcttttaatatttctaatggaGTCCTTTCTGACCAGCAATCCTGTCCCTTATGCATAAATGGCTTCATGAATATGTGTGAAGAGACTTTTCAGTATACGAAGGATATggaattatatgaaaatataattctagATAGCAGTGACGAGGAGAATGTATTCAACAATGCCAAGGTTGATAAGAAAAGTGGTGGAATTTGTTCTATCACCTTACAATGCTTGGGAACCAGGCAGAAATATCTAAAATGTGGAGCGTGCATGAATCTTTATCATACCGAGGAGACACTAAACAGTCATAAATGTAAGCCCAGTATGCAGAATACAACAAAACCGTACCAATGTCTTGTATGTGACAAGACATTTACTTTCGAAGAACGATTAAATTTTCACATGCAATTTCACAAAGGTGCGAAAGCATTGTATTGCGAGGTCTGTAAGATAACGTTCGGTAAAGAGCTGAAGCTGTTCTACCATTACAAAAGACAACATTCTAAGGAGATTAGTGTCTCGTGTCTACAATGTGGAAAATTATTCGAGAATCAGGAAGCGCTTCGAGTGCACGTTTGCGTTGACGGTAAAAATCGACCTCATATTTGCGAAGTGTGCAACAAAGGCTTTTTTGATGGCTACACTCTGAAGCGTCACGTAGTGACACACCTGCCTGAGAAGCCTTACAAATGCTCGGAATGCTCAAAGAGTTTTACACAGAAATCGAGATTGAACAAGCATGTCGCGAGCCACTGCATAGTTATCGAGAACAGCCAGACGGTCTGGAAATGCGTCCAGTGTGGTGAGGTATTCACCTCTTGCGACGATGCAGATATTCATTACAAGATAATACACGAGGACAAGATCACGCTGATCGAGGAACTGGTGGCATCCAAGCTGTATCATTGCGAGTTTTGCAACAGCCATTTTACCAACGCGGACAACTTGAACATTCATCAAAAATGTCACGTTGTCGAAAAACCCTACACATGTAATACCTGTATGGCCACTTATAAATCATTCGCGGAAGCTGTTTTACATTGGAAGGAACATCCCAGACTGTTTAAAGTTCTCGTCGTCTTCTTGTGCGACGTCTGTAATAAGGACATGAAGGAATTATCCCTGCTGTACAAGCACAAGCAAAATCGGCACGACCATGCATCCAGATTATCAGAATCGGGCGACGCAAAATTCATCTGCGAACTCTGCGGGACTGTGTTCGACAAAAGCGAGGATATACAGGATCACGGACGAGATCAATGTTCCAAGTTTCCCTGTGACATTTGTGGCAGCCTGCTGCCTACGGCAAACTCCTTGAATGCACACAAAAGGCGGCATAACGGATTGAGACCATATGTTTGTAACATTTGCGGAAAGAGTTATACTCAGTCCAGCCACATGTGGACTCACAAGAGATTCCACATGGGCATCAAGCCTTACGCCTGCGAATATTGCGAGCAGCGTTTCACGATAAAGCCGGACTTGGCGGATCACATTAGGAAGAAGCACACGAGGGAAAGGCCGTTCAAGTGCGACGTCTGCAACAAGGCTTTCCTGACCGGATCCGTCTTTTATCAGCACAGATTGATACACCGTGGTGATCGTAGATACAAGTGCCACTATTGCGAGAAGGCCTTCACCAGGACGGAGGCTTTGAACAATCACATCAAGATACACACTGGGGAAAAGCCGCATTCGTGCGACGTATGCGGCAGATGCTTCAGACAGAAGGGAGATATGAGGAAACACAGACGCACGAAGCACGCTTCTGAACAGAACAAATCTTGA
Protein Sequence
MSKPESISTLSDHEDDIDNLDGSMLWSQEEPLSSNEILELSAQDEKENSLFSFCRLCAGQTTNPIYIYSEFGESMKLAHKINTCLSVKIKKTDPLPKQLCSTCVEKVNWYDKFDAQCIKAEEILSTMLKEKQSFNISNGVLSDQQSCPLCINGFMNMCEETFQYTKDMELYENIILDSSDEENVFNNAKVDKKSGGICSITLQCLGTRQKYLKCGACMNLYHTEETLNSHKCKPSMQNTTKPYQCLVCDKTFTFEERLNFHMQFHKGAKALYCEVCKITFGKELKLFYHYKRQHSKEISVSCLQCGKLFENQEALRVHVCVDGKNRPHICEVCNKGFFDGYTLKRHVVTHLPEKPYKCSECSKSFTQKSRLNKHVASHCIVIENSQTVWKCVQCGEVFTSCDDADIHYKIIHEDKITLIEELVASKLYHCEFCNSHFTNADNLNIHQKCHVVEKPYTCNTCMATYKSFAEAVLHWKEHPRLFKVLVVFLCDVCNKDMKELSLLYKHKQNRHDHASRLSESGDAKFICELCGTVFDKSEDIQDHGRDQCSKFPCDICGSLLPTANSLNAHKRRHNGLRPYVCNICGKSYTQSSHMWTHKRFHMGIKPYACEYCEQRFTIKPDLADHIRKKHTRERPFKCDVCNKAFLTGSVFYQHRLIHRGDRRYKCHYCEKAFTRTEALNNHIKIHTGEKPHSCDVCGRCFRQKGDMRKHRRTKHASEQNKS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01354793;
90% Identity
iTF_00765849;
80% Identity
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