Basic Information

Insect: Sialis lutaria
Gene Symbol: topi
Assembly: GCA_949319165.1
Location: OX439243.1:13723099-13727355[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.00066 0.036 14.8 1.4 2 21 149 168 148 169 0.94

2 12 3e-05 0.0016 19.0 4.4 1 23 193 215 193 215 0.98

3 12 0.00052 0.028 15.1 0.2 1 23 221 243 221 243 0.97

4 12 2.3e-06 0.00012 22.5 1.9 1 23 411 433 411 433 0.99

5 12 0.0072 0.39 11.5 1.6 3 21 477 495 475 499 0.88

6 12 0.0037 0.2 12.4 0.6 1 23 679 702 679 702 0.96

7 12 0.062 3.4 8.6 1.6 1 23 706 728 706 728 0.92

8 12 1.1e-06 6.2e-05 23.5 2.4 1 23 734 756 734 756 0.98

9 12 0.039 2.1 9.2 0.2 1 23 762 787 762 787 0.96

10 12 0.072 3.9 8.3 2.5 1 23 793 815 793 815 0.85

11 12 8e-06 0.00043 20.8 0.9 3 23 823 843 821 843 0.98

12 12 4.2e-05 0.0023 18.5 2.6 1 23 849 872 849 872 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.00066	0.036	14.8	1.4	2	21	149	168	148	169	0.94
2	12	3e-05	0.0016	19.0	4.4	1	23	193	215	193	215	0.98
3	12	0.00052	0.028	15.1	0.2	1	23	221	243	221	243	0.97
4	12	2.3e-06	0.00012	22.5	1.9	1	23	411	433	411	433	0.99
5	12	0.0072	0.39	11.5	1.6	3	21	477	495	475	499	0.88
6	12	0.0037	0.2	12.4	0.6	1	23	679	702	679	702	0.96
7	12	0.062	3.4	8.6	1.6	1	23	706	728	706	728	0.92
8	12	1.1e-06	6.2e-05	23.5	2.4	1	23	734	756	734	756	0.98
9	12	0.039	2.1	9.2	0.2	1	23	762	787	762	787	0.96
10	12	0.072	3.9	8.3	2.5	1	23	793	815	793	815	0.85
11	12	8e-06	0.00043	20.8	0.9	3	23	823	843	821	843	0.98
12	12	4.2e-05	0.0023	18.5	2.6	1	23	849	872	849	872	0.98

Sequence Information

Coding Sequence: ATGTGTGATTCGGTAGACGAAAAcgacatatatttaaaactgcATCAAATGGAAAACACAGATTCTGTACATTTGGGAGACACAAGTCACAATCAGTTTATTTCACAATCTTTACTCTCACATGAAGATGTAAAACTCGAAGAACCCACAATGCAGTGGGGCTACGTAATAGACACCGACTCGAAAATAGACATCAAGTTCCAAGACTATGAACCGAAACCTGCAACAATTACTCTAATTAAGATTGGAGGGATCGAAGATCTGAACCCGTTAAATTACACAAACCACATGAATCAAGGAATGAATCCATTCTCCAATCAAATTATAATTCCGAGTAATATAATACCTGAGCAGTTTCACAGTGAGACGACGATTTCAAAAGAAGTTAAAGAcaagccaaaaaaaaaatacccaccTCCGCAAATGCAGAATGAACCTATTGTCACTTGCCAGAACTGCGACGCTTCCTTCGTAACAAAATACCAATACCAGAGACACCAATGTGACTTTGATGCGACGCGAGTGACTCTTAAAACTGAGATACCCAAACGGTACATTGAGAAACCGAAAACCAAGTACGAATGCGAGTTGTGCCATAAGTCATTCATGACTGAACATAATCTGGAACGACACCGGTTGTCTCATGAAGATAAGAAACCATTTGTTTGTCAAAACTGCGGGAAGGGATTCGTGCTCGAGTCGAGACTGAATTCTCATATTGAGAACCATTGCAAGCTGAATCAAAACGAGACGAGGAAGTATTACCGGACTGATTTGACTGTCTGGGAATGCTGGAACTGCAAACTGATAGTTGCAATTGAACCTATCCACATGATCCACGTTTGCGGAAATGCAAATCCTACCTTCATCCAGAACCAAATATACATCCCTTTCCCAAATCCTGAAAATGTGGACAGACCCATTCCTATCTATTCGAACCCAATTGAAAATAGCGATGGTGTGCATTATACAGaaatgaaaaatgtttcagaGAAACTAGTGTTCGAGGATTCTAGTAAAATAATCCAAATCATCagcgaaaattataaaaatgatcaGGAGTATGACCAAAATAACTTCGACCGGAATTTCGAAAAGGCTATTATTGGGATCGACTCTTTCAACGATAGTTTATACAACAAACAGCAGACTTTGATTCCAAAGGTAGAGATGAACAAAAGTAAAGAGACTGTAGAACATATGTTCAAGAAAATCAGCGTAGAACATTTATACCAGTGCGAATTTTGTAACAGGACGTACGCAGATAAAACTAACTTGAAGGAGCATCAGAACACACATAAAACTGATAAGAACTTTGAGTGTATGTTCTGCACAAGCTCATTTGACAGCTACACAAGCGCTCTGGTTCACTGGCAGCACAAATGCGAACAGAAGCTGAACTTGTTCTGTCTGCCAAAAATAATCATTTGTAAAATATGCGAAAAGAACTTTAAATCTCACGAACTTTTGTACGCCCATAAATACAAACTTAAGCATTTTACTccaaaagtttttgttataaatgaatACCATGTATTTGccgaagaaaataatttaatggaTAATGGAGAAAATAGCGAACCGATtactatgaatattgaacaggAAAATGAACAAAGAAACTACGATTCAGATGAGTCGGATCAGATAGATCAATATCTGAAAGAAATCGAAAATAAGATCTTAGAAAAGAGTTTATCGAAAGAAGAAACCACAGATGTAATTAAAGAAGCTGATATACAAATAGAAGAACAGATGGTACAAAGAGTACTGAGAAGCAGTTCGAAGAAGAATAAGAATCCAGAAGAAACCGAACAAGAAAAAGAAAACATCGAAACTGTTGCATTAAAgaaacgtaaaaaaaaaaataaagaagatGAAATCAATACTGAGAACATAAAACAAGAACCTGACATGACGATTGAAGAAATACCGGAAGTGAAAGCGGTGCAGGTTCCTGCAAAACGGGGCCGCAAGCCCAAGCCCAAGGTCATCATGGAGGAGATGGTATACACGTGCGACACCGGCTACAGGTTCCAATGTGAGAAGTGCTCAAAGCTAGTGACATCAATCGACGAGTTAACAAAGCACAGGCAATTGGAGCATGGCAGCAAGTTTGACTGTAAGGACTGTGGACAGGTCGTGCACAGCTCCAAAGCGCTGATGATACACTGCAGGGCCCACCAGAGCCTCAAGCCATACGTATGCGACCAGTGTGGCCGCAGCTACTCCCAGACGTCTCACCTGTGGCAGCACATGCGCTTTCACCAAGGAATAAAGCCGTTTGCTTGCCCGCACGAGGGCTGTGAAGCCAGGTACACAATCAGACCCGATCTCAAAGACCACATCCGTAAAGTCCATACTCGAGAACGCCCCTTCCGTTGTAACGTCTGTGGGAAGTGTTTTCTGACAGGGTCCGTCTACTATCAACACCGGCTCATTCACAACAACGATAGGCGATATGGGTGCGATATATGTGGTAAGAGGTTTTTCCGTGCAGATGCGCTGAATAATCATCATCGGATTCATACAAACGAGAGACCGTTTCCATGTTCAGTTTGTGGAAGGGAGTTCCGACAGAAGGGAGACAGAAACAAGCACCACCGTACTCAACATCCTGCTCATCAAAACACTTTTAATATTGGCCTCTCTCTTAGTGCTTAA
Protein Sequence: MCDSVDENDIYLKLHQMENTDSVHLGDTSHNQFISQSLLSHEDVKLEEPTMQWGYVIDTDSKIDIKFQDYEPKPATITLIKIGGIEDLNPLNYTNHMNQGMNPFSNQIIIPSNIIPEQFHSETTISKEVKDKPKKKYPPPQMQNEPIVTCQNCDASFVTKYQYQRHQCDFDATRVTLKTEIPKRYIEKPKTKYECELCHKSFMTEHNLERHRLSHEDKKPFVCQNCGKGFVLESRLNSHIENHCKLNQNETRKYYRTDLTVWECWNCKLIVAIEPIHMIHVCGNANPTFIQNQIYIPFPNPENVDRPIPIYSNPIENSDGVHYTEMKNVSEKLVFEDSSKIIQIISENYKNDQEYDQNNFDRNFEKAIIGIDSFNDSLYNKQQTLIPKVEMNKSKETVEHMFKKISVEHLYQCEFCNRTYADKTNLKEHQNTHKTDKNFECMFCTSSFDSYTSALVHWQHKCEQKLNLFCLPKIIICKICEKNFKSHELLYAHKYKLKHFTPKVFVINEYHVFAEENNLMDNGENSEPITMNIEQENEQRNYDSDESDQIDQYLKEIENKILEKSLSKEETTDVIKEADIQIEEQMVQRVLRSSSKKNKNPEETEQEKENIETVALKKRKKKNKEDEINTENIKQEPDMTIEEIPEVKAVQVPAKRGRKPKPKVIMEEMVYTCDTGYRFQCEKCSKLVTSIDELTKHRQLEHGSKFDCKDCGQVVHSSKALMIHCRAHQSLKPYVCDQCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFRCNVCGKCFLTGSVYYQHRLIHNNDRRYGCDICGKRFFRADALNNHHRIHTNERPFPCSVCGREFRQKGDRNKHHRTQHPAHQNTFNIGLSLSA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01343365;
90% Identity: iTF_01343365;
80% Identity: -