Basic Information

Insect: Sialis fuliginosa
Gene Symbol: topi
Assembly: GCA_961205875.1
Location: OY540814.1:13670879-13674216[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.00062 0.033 14.8 1.4 2 21 149 168 148 169 0.94

2 12 2.9e-05 0.0015 19.0 4.4 1 23 193 215 193 215 0.98

3 12 0.00048 0.026 15.1 0.2 1 23 221 243 221 243 0.97

4 12 4e-06 0.00021 21.7 1.2 1 23 411 433 411 433 0.99

5 12 0.0068 0.36 11.5 1.6 3 21 477 495 475 499 0.88

6 12 0.0035 0.19 12.4 0.6 1 23 680 703 680 703 0.96

7 12 0.058 3.1 8.6 1.6 1 23 707 729 707 729 0.92

8 12 1.1e-06 5.8e-05 23.5 2.4 1 23 735 757 735 757 0.98

9 12 0.037 2 9.2 0.2 1 23 763 788 763 788 0.96

10 12 0.068 3.7 8.3 2.5 1 23 794 816 794 816 0.85

11 12 4.1e-06 0.00022 21.6 0.3 3 23 824 844 822 844 0.98

12 12 4e-05 0.0021 18.5 2.6 1 23 850 873 850 873 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.00062	0.033	14.8	1.4	2	21	149	168	148	169	0.94
2	12	2.9e-05	0.0015	19.0	4.4	1	23	193	215	193	215	0.98
3	12	0.00048	0.026	15.1	0.2	1	23	221	243	221	243	0.97
4	12	4e-06	0.00021	21.7	1.2	1	23	411	433	411	433	0.99
5	12	0.0068	0.36	11.5	1.6	3	21	477	495	475	499	0.88
6	12	0.0035	0.19	12.4	0.6	1	23	680	703	680	703	0.96
7	12	0.058	3.1	8.6	1.6	1	23	707	729	707	729	0.92
8	12	1.1e-06	5.8e-05	23.5	2.4	1	23	735	757	735	757	0.98
9	12	0.037	2	9.2	0.2	1	23	763	788	763	788	0.96
10	12	0.068	3.7	8.3	2.5	1	23	794	816	794	816	0.85
11	12	4.1e-06	0.00022	21.6	0.3	3	23	824	844	822	844	0.98
12	12	4e-05	0.0021	18.5	2.6	1	23	850	873	850	873	0.98

Sequence Information

Coding Sequence: ATGTGTGACTCGGTAGACGAAACCGACATATATTTAAAACTGCATCAAATGGAAAACTCTGATTCTATACATTTGGGAGACTCAAGCCACAATCAGTTTATTTCACAATCTTTACTCTCGCATGAAGATGTGAAACTTGAAGAACCCACAATGCAGTGGGGCTACGTAATAGACACTGATTCGAAAATAGACATCAAGTTCCAAGACTATGAACCGAAACCTGCAACAATTACTCTAATTAAGATCGGAGGGATCGAAGATCTGAATCCGTTAAATTACACAAGCCACATCAATCAAGGAATAAATCCATTCTCCAATCAAATTATAATTCCCAGTAATATAATACCTGAGCAGTTCCACAGTGAGACAACGATTTCAAAAGAAGTTAAGGAcaagccaaaaaaaaaatatgcaccTCCGCAAATGCAGAACGAACCTATTGTCACCTGCCAGAACTGCGATGCTTCCTTCGTGACTAAATACCAGTACCAGAGACACCAATGTGACTTTGATGCATCGCGAGTAAATCTTAAAACCGAGATACCCAAACGGTATATCGAGAAACCGAAAACCAAATACGAGTGCGAGTTGTGTCACAAGTCATTCATGACAGAACATAATTTGGAACGACACAGGTTGTCTCACGAAGATAAGAAACCATTCGTTTGTCAGAACTGTGGGAAGGGATTCGTGCTCGAGTCGAGACTGAATTCTCATATCGAGAACCATTGCAAGCTGAATCAGAACGAAACGAGGAAGTATTACCGGACTGATTTGACTGTCTGGGAATGCTGGAACTGCAAACTGATAGTTGCAATTGAACCTATCCACATGATCCACGTTTGCGGGAACGCAAATCCTACCTTCATCCAGAACCAAATATACATTCCTTTTCCAAATCCTGACAACATTGACAAAACCGTTCCTATCTACTCGAACTCGATTGAAAATAGCGATGGTGTGCATTACACAGAaatgaaaaatgtttcagaAAAACTAGTGTTTGAGGATTCTAGTAAAATAATCCAAATCATCagcgaaaattataaaaatgatcaGGAATACGATCAAAATAACTTCGACCGAAATTTCGAAAAGGCTATCATTGGGATCGACTCTTTTAATGACAGTTTGTACTGCAAACAGCAGACTTTAATTACGAAGGTAAACGTGAGCAAAAGTAAAGAGACTGTAGAACATATGTTCAAAAAAATCAACGTAGAACATCTGTACCAGTGCGAATTTTGTAACAGGACTTATGCAGATAAAATTAACTTGAAGGAGCATCAGAACACACATAAAACTGATAAGAACTTTGAGTGCATGTTCTGCACAAGCTCATTTGACAGCTACACAAGTGCTCTGGTCCACTGGCAGCACAAATGCGAACAGAAGCTGAACTTGTTCTGTCTGCCAaagataattatttgtaaaatatgcgaaaaaaactttaaatctcACGAACTTTTATATGCCCATAAATACAAGCTTAAGCATTTTACTCCTAAAGTCTTTGTTATAAATGAGTACCATGTGTTTAccgaagaaaataatttaatgaataaCGGAGAAAATACTGAATCGATTAATATGGATATTGAACAAGACAATGAACAGAGAAACTACGATTCAGATGAGTCAGATCAGATTGATCAgtatctgaaagaaattgaaaaTAAGATCCTAGAAAAGAGTTTATCGAAACAAGAAAACACAGAAGATCTAATTAAAGAAGCTGAAATACAAATAGAAGAAAAGATGGTACAAAGAGTATTGAGAAGCAGTTCGAAAAAGAATAAGAATCCGGAAGAAACTGAACAAGAAAAAGAAAACATCGAAAccattacattaaaaaaacgtaaaagAAAAAACAAAGAAGATGAAATTGACACTGGGAACATAAAGCAAGAACATGATACGACAATTGAAGAAACACCTGAACTGAAAGCGGTGCAGGTACCTGCGAAGCGGGGCCGCAAACCCAAACCCAAGGTTATCATGGAGGAGATGGTGTACACTTGCAATACCGGCTACAGGTTCCAATGTGAGAAGTGCTCAAAGCTAGTCACGTCGATCGACGAGCTAACGAAGCACAGGCAGTTGGAGCATGGCAGCAAGTTTGACTGCAAGGACTGTGGACAGGTTGTGCACAGCTCTAAAGCGCTGATGATCCACTGCAGGGCCCACCAGAGCCTTAAGCCGTACGTGTGCGACCAGTGCGGCCGCAGCTACTCACAGACATCTCATCTGTGGCAACACATGCGCTTTCACCAAGGAATAAAGCCGTTTGCTTGCCCACATGAAGGCTGCGAAGCCAGGTACACAATCAGGCCCGACCTCAAAGACCACATCCGTAAAGTCCATACTCGAGAACGCCCCTTCCGTTGTAACGTCTGTGGGAAGTGTTTTCTAACAGGGTCCGTCTACTACCAGCACCGGCTCATTCACAACAACGATAGGCGATACGGGTGCGATatATGTGGTAAGAGGTTTTTCCGTGCAGACGCGCTGAATAATCATCGTCGGATCCATACAAACGAGAGACCGTTTCCATGTTCGGTTTGTGGAAGGGAGTTCCGACAGAAGGGGGATAGGAACAAACACCACCGTACTCAACATCCTACTGATCAAAACACTTTTAATATTGGCCTCTCTCTTAGTGCTTAA
Protein Sequence: MCDSVDETDIYLKLHQMENSDSIHLGDSSHNQFISQSLLSHEDVKLEEPTMQWGYVIDTDSKIDIKFQDYEPKPATITLIKIGGIEDLNPLNYTSHINQGINPFSNQIIIPSNIIPEQFHSETTISKEVKDKPKKKYAPPQMQNEPIVTCQNCDASFVTKYQYQRHQCDFDASRVNLKTEIPKRYIEKPKTKYECELCHKSFMTEHNLERHRLSHEDKKPFVCQNCGKGFVLESRLNSHIENHCKLNQNETRKYYRTDLTVWECWNCKLIVAIEPIHMIHVCGNANPTFIQNQIYIPFPNPDNIDKTVPIYSNSIENSDGVHYTEMKNVSEKLVFEDSSKIIQIISENYKNDQEYDQNNFDRNFEKAIIGIDSFNDSLYCKQQTLITKVNVSKSKETVEHMFKKINVEHLYQCEFCNRTYADKINLKEHQNTHKTDKNFECMFCTSSFDSYTSALVHWQHKCEQKLNLFCLPKIIICKICEKNFKSHELLYAHKYKLKHFTPKVFVINEYHVFTEENNLMNNGENTESINMDIEQDNEQRNYDSDESDQIDQYLKEIENKILEKSLSKQENTEDLIKEAEIQIEEKMVQRVLRSSSKKNKNPEETEQEKENIETITLKKRKRKNKEDEIDTGNIKQEHDTTIEETPELKAVQVPAKRGRKPKPKVIMEEMVYTCNTGYRFQCEKCSKLVTSIDELTKHRQLEHGSKFDCKDCGQVVHSSKALMIHCRAHQSLKPYVCDQCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFRCNVCGKCFLTGSVYYQHRLIHNNDRRYGCDICGKRFFRADALNNHRRIHTNERPFPCSVCGREFRQKGDRNKHHRTQHPTDQNTFNIGLSLSA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01344313;
90% Identity: iTF_01344313;
80% Identity: -