Sinf042971.1
Basic Information
- Insect
- Sesamia inferens
- Gene Symbol
- -
- Assembly
- GCA_037179545.1
- Location
- CM073946.1:13033747-13056838[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 4 1.1 4.5e+03 -0.8 0.0 98 119 217 238 166 240 0.76 2 4 0.19 7.7e+02 1.6 0.1 19 59 253 293 248 301 0.81 3 4 0.00011 0.44 12.1 0.0 17 80 364 426 358 446 0.82 4 4 0.0039 16 7.1 0.0 19 64 456 501 449 513 0.88
Sequence Information
- Coding Sequence
- ATGTACAATATGAAAGACTCTGGATTGATCGATATGTTTCAAAGTGTCACAGGAATATCGGGTGTCGAAAAAAAAGCCAGTCTACTACAGAGAGTTTGTTGGGAATGCGCTGCGCGTCTCACAGCGGCTTCAGCATTCAAAGAAAAAGCGCTACTCAGCAATTCATTGCTAAAACACCAAGTACACATCAGAGAAAGTGATATAGCATTACTAAAACAAAATCACAGTTCTTTAAAATCACGTCTATGCGTTAAAACAGCAGTTACTTCATTTGATATTGAATTCGAACATATTGAATCTGGAGATATAGAAACAAATATATCTCGCAGCAGTGAGACAGATATCCAAGAACGAAAGCATGAAATGAGagtagtttttgaacaagaaaGAGAGAACGCATTTGAACAGTACGAATCTTGGATAGATGTTCCCGTGAAAACTGAGATAGAATGTGATCCTATAGCTGATAACACTGTGCAAGAAGATAGTGAAGATATGATCACAAATACTGAAGTACAAATGAATAATGATGAAATAAGAAATGATGCTCCGAATAAAATCCCCCACGTGACTGATGCTAGTAACGTTACAGTAGACAAAGAAAGAAATATCAAGCCTGATGTTAGTGGTAAGATTGTGGACGAGACCTGGATTAGAGAACACGTGCTAAGTACAATGATGGCGGGCAGTAAGTCTGAGCCAACGGTGAGCAGTGAGGCAGGGGCTCCGGCGAAAAAAAGGCGTACGTACTTGATTAATGAGCGGATTAAAGAAAAGATAGTTAGGATGAAGGCTGAAGGTTGCACCGTCGCTGCAATATGTAATGAAACTGGACTGTCGATATCGTCTATAACTTGTTGGTGGAGACGCTACCGTAAAAGCAATAATTTATTCCAAAGATACCGGATACCTCCAAGACACCGGAGCGGTCAAATCCAACATTTTTGTCACATCGCTTCAGAACCTGGGAAAGAGATGGAGGATTGTCCCAAAATAGTGAGGGAGAGATTATGTGAAGCTGGTCTTGAACATATCCTCATGAAGAAGCCTGGAACTGTTACGACGCCGACGAATATAagTCCGCGTAAAGCACTCCATGAGGACTTAAAAAGGCGAATAGTAGCGCTGAAGCAAGAGGGAATGTCTAATAGCCGGATAGCTTATCTGTTAAATACTGCACGAAACACAGTTCAGAAGTGGTGGACTCGCTGGTGCAATGAAGGTTCCATGGAAGATCACAAGCAGCCTGGACGGAGGAGGAAAACTACTCCGGAGGAAGACCAGCTCTTGATAGAGCGGGTGGCTCAAGAACAAACTGTGCATACGCCCTCCCTGGCGAAAGAATTTGGCATTTCGTTGAAgGTCGATGAGGAAGTCAAACAGCAGATAATATCGATGAAATTAAATGGAATTTCAGTCACCGACATTGCCAACCAATTTCGAGTTCCAcgaACCACAATCTACCAGTGGTGGCAGAGATGGTGCAAGGAAAATAACATTAAAGTAACCAACAATAAAAACACAAGTACGGCAGCTGAACAAGACCACGGATTAGCAGAGCATGCTCACGGCGAAATGATCGTGGAAACGCCATCGATAGTGTCTTCACAGAAGTCTTTGTGGCAGAAACCGCCAGATTTGTAA
- Protein Sequence
- MYNMKDSGLIDMFQSVTGISGVEKKASLLQRVCWECAARLTAASAFKEKALLSNSLLKHQVHIRESDIALLKQNHSSLKSRLCVKTAVTSFDIEFEHIESGDIETNISRSSETDIQERKHEMRVVFEQERENAFEQYESWIDVPVKTEIECDPIADNTVQEDSEDMITNTEVQMNNDEIRNDAPNKIPHVTDASNVTVDKERNIKPDVSGKIVDETWIREHVLSTMMAGSKSEPTVSSEAGAPAKKRRTYLINERIKEKIVRMKAEGCTVAAICNETGLSISSITCWWRRYRKSNNLFQRYRIPPRHRSGQIQHFCHIASEPGKEMEDCPKIVRERLCEAGLEHILMKKPGTVTTPTNISPRKALHEDLKRRIVALKQEGMSNSRIAYLLNTARNTVQKWWTRWCNEGSMEDHKQPGRRRKTTPEEDQLLIERVAQEQTVHTPSLAKEFGISLKVDEEVKQQIISMKLNGISVTDIANQFRVPRTTIYQWWQRWCKENNIKVTNNKNTSTAAEQDHGLAEHAHGEMIVETPSIVSSQKSLWQKPPDL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01340075;
- 90% Identity
- -
- 80% Identity
- -