Scos031660.2
Basic Information
- Insect
- Scrobipalpa costella
- Gene Symbol
- PAX1
- Assembly
- GCA_949820665.1
- Location
- OX463314.1:17408289-17426123[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 5.7e-69 2.5e-65 219.3 0.2 3 125 80 202 78 202 0.99
Sequence Information
- Coding Sequence
- ATGTCACCTGCGCCGGCGCAGCTCGCGGTCACGCTCTCCGTCGCCGGTAGCTGTTTGTCTAGCGGGGCGTTTGTCGGCGCGCCTCGCCGTGTGTGGTCCGGCCTTAAGAGCCCTTTAAGCTTCAAGCCCTTCACCAGACGACGGCCAAGACAGCCCTGTTATGCAGACCCGAATGGGGGCATGAGTGGCGGCATGGGCGGTGTGGGCGGCATGGGGGGCGCAGGGGCGCAGCAGTACGGGGAGGTCAACCAACTCGGGGGGGTCTTCGTCAACGGACGGCCGCTGCCCAACGCTGTAAGGCTACGAATAGTGGAGCTAGCACAACTTGGTATTAGGCCATGTGACATTAGTCGGCAGCTGAGGGTATCCCACGgttgcgtgtcgaaaatcctcGCCAGATACCACGAGACAGGCTCCATACTGCCTGGAGCCATTGGCGGCTCCAAACCTAGAGTCACCACACCTAAGGTGGTGTCATACATAAAGCAATTAAAGGCGAAGGACCCCGGCATTTTCGCGTGGGAGATCCGGGACAGGTTGCTGGCTGACGGCGTCTGCGACAAGTACAACGTGCCGTCCGTCTCCAGCATCAGCCGGATCCTGAGGAACAAGCTGGGGGGCGCGGCGCTGTACCCCGTACCCCCCCTGTACCCTGTCCCACCGCAGCGGTGTTGGCCACTGCACCAGCCTTACGACTATTATGTGTATTTACAGGGTCGACAGCACACAACCGCAGCCCCGCACGGGCTACCCCACCCACACCAGCAGGCACCCCACCATGCGCACACGCACGCGCTCTGA
- Protein Sequence
- MSPAPAQLAVTLSVAGSCLSSGAFVGAPRRVWSGLKSPLSFKPFTRRRPRQPCYADPNGGMSGGMGGVGGMGGAGAQQYGEVNQLGGVFVNGRPLPNAVRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYHETGSILPGAIGGSKPRVTTPKVVSYIKQLKAKDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKLGGAALYPVPPLYPVPPQRCWPLHQPYDYYVYLQGRQHTTAAPHGLPHPHQQAPHHAHTHAL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00448104; iTF_00035627; iTF_00932491; iTF_00034700; iTF_00908814; iTF_00931283; iTF_00683287; iTF_00284507; iTF_01173245; iTF_01197693; iTF_01547519; iTF_01317262; iTF_00150496;
- 90% Identity
- iTF_00318832;
- 80% Identity
- -