Samb064449.1
Basic Information
- Insect
- Scoparia ambigualis
- Gene Symbol
- pic
- Assembly
- GCA_963921215.1
- Location
- OY992520.1:4034719-4055772[-]
Transcription Factor Domain
- TF Family
- SRF
- Domain
- SRF domain
- PFAM
- PF00319
- TF Group
- Helix-turn-helix
- Description
- Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 14 2 3.7e+04 -3.4 0.0 37 45 330 338 329 339 0.85 2 14 0.021 4e+02 2.9 0.0 19 38 418 437 416 447 0.79 3 14 0.028 5.3e+02 2.5 0.0 19 35 436 452 433 460 0.84 4 14 0.044 8.1e+02 1.9 0.0 19 34 454 469 452 473 0.88 5 14 0.021 4e+02 2.9 0.0 19 38 472 491 470 501 0.79 6 14 0.021 4e+02 2.9 0.0 19 38 490 509 488 519 0.79 7 14 0.021 4e+02 2.9 0.0 19 38 508 527 506 537 0.79 8 14 0.021 4e+02 2.9 0.0 19 38 526 545 524 555 0.79 9 14 0.021 4e+02 2.9 0.0 19 38 544 563 542 573 0.79 10 14 0.033 6.1e+02 2.3 0.0 19 35 562 578 560 585 0.85 11 14 0.021 4e+02 2.9 0.0 19 38 580 599 578 609 0.79 12 14 0.021 4e+02 2.9 0.0 19 38 598 617 596 627 0.79 13 14 0.021 4e+02 2.9 0.0 19 38 616 635 614 645 0.79 14 14 0.034 6.3e+02 2.2 0.0 19 41 634 656 632 663 0.79
Sequence Information
- Coding Sequence
- ATGAACTCCTCGCACCACGACACGCTAATATTGGCGTTCGTGGGGCAGACCAGGGTTTTAGCTCTAAATGGAGAAGAAGTAGAAGAAACCGAAATCAAAGGATTTGTGTCCGACCGACAGACATTCTTCACGGGAAACGTATGCCATGACCAGTTGATCCAGGTGACCGACGAGGGCATAAGCCTGATCACGCGCTGCGCCGACGGCGGCTGGCAGCCGGGCGCGGCGTGGCGCGCGGGCGGCGAGCGCGGCGTGTCCGTGGTGGCGTGCGGCGGCACGCGCGCCGTGTGCGCCGCGGGCCCGAGGCTCTATCTGGTCGCCATACACGAGGGCCGGCTCGAGCTGCTCGCTGAGGTGTGCATGGAGGAGGAGGTGGCGTGCCTAGACCTGGGCCCGGGCGGGGAGAACGCCCTGCTGGGCGTGGGGCTGTGGACCGACATCTCGGTGCGCGTGCTGCGGCTGCCTACGCTCGAGCCGCTGCACACCGAGAAGCTGTCGGGAGATCTCGCAAAGGCGTTTGATACGGTGTCCATTGAACTTCTTCTGCATAAAATGGAAATGATTGGCATACGTGGGAAAGTTCTCCAACTCTTCACTAGCTACCTGTCTCATCGAATGCAAAGAGTAAAAATTGGTGATTTGACCTCTGGTGACGCACAGtgGCGTaggcgaaggcgcgggcgggccgctagtaactgCAGACGACGACTCACTTTCCCGGCCAGCAGTCCAAGGCGTGAGTTGATGCGGCCGGATGCACTGTTTGCAGAGATCATCCCGCGCTCGCTGCTGATCTGCGTGCTGGAGGGCGTGTGCTACCTGCTGTGCGCGCTGGGCGACGGCTCCATGTTCTACTTCACCGTGGACCAGGACTCCGGCGCGCTCACCAACAAGAAGAAGTTCACGCTGGGCACGCAGCCCACCGTGCTGAGAACCTTTCGGTCGCTGTCGACGACGAACATATTCGCGTGCTCGGACCGGCCCACGGTGATATTCTCGTCCAACCACAAGCTGGTGTTCTCCAACGTGAATCTCAAGGAGGTCACGCACATGTGCTCCCTCAACGCGCTCGCCTATCCCGACAGCCTGGCGCTGGCGACGGACAGCACGGTGACGATCGGCACCATCGACGAGATCCAGAAGCTGCACATCCGCACCGTGCCGCTGGGCGAGACGCCGCGCCGCATCGCCTACCAGGAGGCCACGCAAGCCACGCAACTGAGCACTGCTTGGGACACTAACATACACTACCTACTAACAAAGGCCACGCAACTGAGCACTGCTTGGGACACTAACATACACTACCTACTAACAAAGGCCACGCAACTGAGCACTGCTTGGGACACTAACATACACTACCTACTAACAAAGGCCACGCAACTGAGCACTGCTTGGGACACTAACATACACTACCTACTAACAAAGGCCACGCAACTGAGCACTGCTTGGGACACTAACATACACTACCTACTAACAAAGGCCACGCAACTGAGCACTGCTTGGGACACTAACATACACTACCTACTAACAAAGGCCACGCAACTGAGCACTGCTTGGGACACTAACATACACTACCTACTAACAAAGGCCACGCAACTGAGCACTGCTTGGGACACTAACATACACTACCTACTAACAAAGGCCACGCAACTGAGCACTGCTTGGGACACTAACATACACTACCTACTAACAAAGGCCACGCAACTGAGCACTGCTTGGGACACTAACATACACTACCTACTAACAAAGGCCACGCAACTGAGCACTGCTTGGGACACTAACATACACTACCTACTAACAAAGGCCACGCAACTGAGCACTGCTTGGGACACTAACATACACTACCTACTAACAAAGGCCACGCAACTGAGCACTGCTTGGGACACTAACATACACTACCTACTAACAAAGGCCACGCAACTGAGCACTGCTTGGAACACTAACATACACTACCTACTAACAAAGGCCACGCAACCACTGACGGCTTATAACTTTATAAACTGA
- Protein Sequence
- MNSSHHDTLILAFVGQTRVLALNGEEVEETEIKGFVSDRQTFFTGNVCHDQLIQVTDEGISLITRCADGGWQPGAAWRAGGERGVSVVACGGTRAVCAAGPRLYLVAIHEGRLELLAEVCMEEEVACLDLGPGGENALLGVGLWTDISVRVLRLPTLEPLHTEKLSGDLAKAFDTVSIELLLHKMEMIGIRGKVLQLFTSYLSHRMQRVKIGDLTSGDAQWRRRRRGRAASNCRRRLTFPASSPRRELMRPDALFAEIIPRSLLICVLEGVCYLLCALGDGSMFYFTVDQDSGALTNKKKFTLGTQPTVLRTFRSLSTTNIFACSDRPTVIFSSNHKLVFSNVNLKEVTHMCSLNALAYPDSLALATDSTVTIGTIDEIQKLHIRTVPLGETPRRIAYQEATQATQLSTAWDTNIHYLLTKATQLSTAWDTNIHYLLTKATQLSTAWDTNIHYLLTKATQLSTAWDTNIHYLLTKATQLSTAWDTNIHYLLTKATQLSTAWDTNIHYLLTKATQLSTAWDTNIHYLLTKATQLSTAWDTNIHYLLTKATQLSTAWDTNIHYLLTKATQLSTAWDTNIHYLLTKATQLSTAWDTNIHYLLTKATQLSTAWDTNIHYLLTKATQLSTAWDTNIHYLLTKATQLSTAWNTNIHYLLTKATQPLTAYNFIN
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -