Basic Information

Insect: Scoparia ambigualis
Gene Symbol: -
Assembly: GCA_963921215.1
Location: OY992508.1:29579508-29580704[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 8.9e-08 0.00012 24.3 0.2 24 65 61 103 52 157 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	8.9e-08	0.00012	24.3	0.2	24	65	61	103	52	157	0.84

Sequence Information

Coding Sequence: atgcaacaaataaagtgtcacaaaaattcgatgcaaattttgctacccgtgagagttgctagttgcgcttcctttgtgggtataaaacggtcaacacgggttcaatgtgggtcattcgctattcaaccgttgaagaggacacacgcacagattttgatggataccacagctgataaagccgctcaagtggttgcactactgcaatcaggggtgcggcagtgtgatgtcgcccggcaactgaacctgagccgttattccgttcgaagagtgtaccagcgcttcatagagaccggtggctatatccgcagacacggttcgggtagacgtcgctgcacttcggaaagagacgaccggttcgttgtgtcgaactctttgagaaatcgtttctccaacgctgttgagttgcaacagcagctccaggcagttcgcagacgcaccgtaagcgtatctacggttagaagaagattaaaggagaagaagatagcggcccacagagctgctacgggtccaaaattgactgcagcgcatcggcgagcccgcttgcagtttgctcgtgaccacgtcgattggacccttgagcagtggagagctgttctcttctcagacgagacgcgagtgtgtcttttctgcaacgaccgacggagaagagtataccggaggcagggtgaacgtttcgcccaagcctgcatccaggagacggtggaatatggtggcggatcctgcatgttctggggcggtatgtctgctgccggcaaaaccgaccttgtctgcgtctcccggactggaggtgctcgcggacaagggtcgctgactgctcgccgctatgtcactgaggtcctggaagtgcatgtggtcccctttgccgaatcttttggcgaggggttcacattaatgcacgacaacgctcgcgctcacactgcaggcatcgtgagcgacttcttgcagaggtcccaaatctctgtgatgcagtggccagcgcgaagtccggatctgaatcctatagagcacctctgggaccatcttaaacgtaaggttcgatctcgggatccagctccttcgactctacaggagctccaagacgcggtgattgaagaatgggggcttatccctcaagaagagctcctgaagttggtgaggtccatgagggaccgtatggaagccgtgatcagggcaagggggggtaacactagattttaa
Protein Sequence: MQQIKCHKNSMQILLPVRVASCASFVGIKRSTRVQCGSFAIQPLKRTHAQILMDTTADKAAQVVALLQSGVRQCDVARQLNLSRYSVRRVYQRFIETGGYIRRHGSGRRRCTSERDDRFVVSNSLRNRFSNAVELQQQLQAVRRRTVSVSTVRRRLKEKKIAAHRAATGPKLTAAHRRARLQFARDHVDWTLEQWRAVLFSDETRVCLFCNDRRRRVYRRQGERFAQACIQETVEYGGGSCMFWGGMSAAGKTDLVCVSRTGGARGQGSLTARRYVTEVLEVHVVPFAESFGEGFTLMHDNARAHTAGIVSDFLQRSQISVMQWPARSPDLNPIEHLWDHLKRKVRSRDPAPSTLQELQDAVIEEWGLIPQEELLKLVRSMRDRMEAVIRARGGNTRF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01331540;
90% Identity: iTF_00683329; iTF_01334849; iTF_00683330; iTF_01334850; iTF_00683331; iTF_01334851; iTF_01334852; iTF_00683333; iTF_01334853; iTF_01334854; iTF_01334855; iTF_01334824; iTF_01334856; iTF_01334857; iTF_01334858; iTF_01334859; iTF_01334828; iTF_01334860; iTF_01334829; iTF_01334861; iTF_01334862; iTF_01334863; iTF_01334864; iTF_01334865; iTF_01334834; iTF_01334866; iTF_01334835; iTF_01334867; iTF_00683316; iTF_01334836; iTF_00681621; iTF_00683317; iTF_01334837; iTF_01334869; iTF_00683318; iTF_01334838; iTF_00683319; iTF_01334839; iTF_00683320; iTF_01334840; iTF_00682393; iTF_00683321; iTF_01334841; iTF_00682394; iTF_00683322; iTF_01334842; iTF_00682395; iTF_00683323; iTF_01334843; iTF_00682396; iTF_00683324; iTF_01334844; iTF_00682397; iTF_00683325; iTF_01334845; iTF_00682398; iTF_00683326; iTF_01334846; iTF_00682399; iTF_00683327; iTF_01334847; iTF_00683328; iTF_01334848; iTF_01334830; iTF_01334831; iTF_01334832; iTF_00683315; iTF_01331540;
80% Identity: iTF_00683329; iTF_01334849; iTF_00683330; iTF_01334850; iTF_01334851; iTF_01334852; iTF_01334853; iTF_01334854; iTF_01334855; iTF_01334856; iTF_01334857; iTF_01334858; iTF_01334859; iTF_01334860; iTF_00683316; iTF_00681621; iTF_01334869; iTF_00683318; iTF_01334838; iTF_00683319; iTF_01334839; iTF_00683320; iTF_01334840; iTF_00683321; iTF_01334841; iTF_00682394; iTF_00683322; iTF_01334842; iTF_00682395; iTF_00683323; iTF_01334843; iTF_00682396; iTF_00683324; iTF_01334844; iTF_00682397; iTF_00683325; iTF_01334845; iTF_00682398; iTF_00683326; iTF_01334846; iTF_00683327; iTF_01334847; iTF_00683328; iTF_01334848;