Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 3.4 1.9e+03 0.4 0.0 75 107 101 134 99 137 0.87

2 3 1.3e-21 7e-19 69.3 0.1 11 105 189 283 180 288 0.92

3 3 0.27 1.5e+02 3.9 0.1 78 109 288 319 281 320 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	3.4	1.9e+03	0.4	0.0	75	107	101	134	99	137	0.87
2	3	1.3e-21	7e-19	69.3	0.1	11	105	189	283	180	288	0.92
3	3	0.27	1.5e+02	3.9	0.1	78	109	288	319	281	320	0.88

Coding Sequence: ATGTACGACGCAGGAGAAGGATCTAGTATGTCACAAAGTGGAATAAATATTGTGAGCTCTGAAGTGGTGCTTGGCCGTCGGTTAATTCAAGCGCGGGATGTAAAATGGCTTTGCCTGGAAGATATATACCAGAAGTTTTATCGGCCTAACTTCTACGACATTGGCGGCACTTATTTACAGGATGTTTCACAATACTGGTTTACTTATAAAACTGAACAAGTCGGGAACATTTTCCTTCTCCacgtatttatttgtaattactGTGTATCACCCTTTAGTGTTGCCATGAGTcgagaaaataaaattgaaatagatAAAAAGAACAATGCTGCATTTTTACAACTGAATCTTCAggaatttcattttaaaaagctTCCAGAACGATATCACAGTTATATCACAACTTACAATTTCTCAGACCTTGACATAGAAATGTTGAAAGACAGGAAATTATTTATATCAACACAATTTCCAGTCAATACCAATGAACGAATCAGCCTTGagacaataaataatataaaagccAACCATGATTGCAGTGCACTCTTGACTGATCCCATTGGATCAGATTTTACAATAGAATCTTCAGATGGAGCCAAGTTTCAAATCCACAAAGTAATTCTTGCAGCACACAGTGAAGTTTTCAAGGCAATGCTTAAAGAAGAAACAGCTGAGAGTCAGAACAGTTATGTCAAACTTGTTGATATCTGTGAGGATGATCTGCGATGTATGCTAGAATTCATTTACACAGGCACTGTCAAATATAAggataatattaattttggtAGCCTACTTATATTAGCAGATAGATATAATCTGAGAGGTCTTTGGAAACTCTCTCAGTATGTACTGTTTGAACAGATAAACCTAGAGAATGTGTTAGACATACTTGTTATAGCCGATATGTATGATTCTGAATTGTTGAAAATGGAAAcattgaaatttataaaaaagaatcCAGAAGTATTAAAAAGTAGTTCTTTTAAAGAAATAACTAACACAGATTTAGTCAGGGAGTTATGTACTTACTTAGCTTCATAG
Protein Sequence: MYDAGEGSSMSQSGINIVSSEVVLGRRLIQARDVKWLCLEDIYQKFYRPNFYDIGGTYLQDVSQYWFTYKTEQVGNIFLLHVFICNYCVSPFSVAMSRENKIEIDKKNNAAFLQLNLQEFHFKKLPERYHSYITTYNFSDLDIEMLKDRKLFISTQFPVNTNERISLETINNIKANHDCSALLTDPIGSDFTIESSDGAKFQIHKVILAAHSEVFKAMLKEETAESQNSYVKLVDICEDDLRCMLEFIYTGTVKYKDNINFGSLLILADRYNLRGLWKLSQYVLFEQINLENVLDILVIADMYDSELLKMETLKFIKKNPEVLKSSSFKEITNTDLVRELCTYLAS*

Sequence clustering based on sequence similarity using MMseqs2