Basic Information

Gene Symbol
L
Assembly
GCA_035044465.1
Location
JAWNNW010000444.1:17070232-17077680[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 9.7e-06 0.00069 19.9 2.9 1 23 160 182 160 182 0.98
2 18 0.33 24 5.6 6.2 1 23 188 210 188 210 0.97
3 18 1.6e-07 1.1e-05 25.5 3.2 1 23 216 238 216 238 0.99
4 18 1.2e-05 0.00084 19.6 0.4 1 23 244 266 244 266 0.99
5 18 0.16 11 6.6 0.1 2 23 340 365 339 365 0.92
6 18 0.00013 0.0093 16.4 0.4 2 23 396 418 395 418 0.96
7 18 0.026 1.9 9.1 0.7 1 23 483 505 483 505 0.97
8 18 0.0056 0.4 11.2 0.1 3 23 514 534 512 534 0.92
9 18 7.4e-05 0.0053 17.1 0.2 1 23 542 566 542 566 0.93
10 18 4.3 3.1e+02 2.1 0.3 2 20 572 590 571 591 0.91
11 18 4.9 3.5e+02 2.0 1.6 2 23 602 624 601 624 0.95
12 18 0.0024 0.17 12.4 1.1 1 23 670 693 670 693 0.97
13 18 0.0061 0.43 11.1 1.6 2 23 866 888 865 888 0.96
14 18 0.11 7.7 7.2 0.1 1 23 894 916 894 916 0.92
15 18 0.52 37 5.0 0.4 2 23 924 945 923 945 0.93
16 18 0.92 66 4.2 0.5 2 23 1044 1065 1044 1065 0.94
17 18 0.023 1.6 9.3 0.0 1 23 1075 1097 1075 1097 0.96
18 18 0.00047 0.033 14.6 1.3 1 23 1102 1124 1102 1124 0.97

Sequence Information

Coding Sequence
ATGATGGCTTTAAAGATGTTGTATCGCGGTCACAGTTCGCGTTTGGAGAACTTAATTGAAAAGATTCAGGCCACCAAGGAGATAACAAATAACGATATGTACAGCACGCATACCTCCTCGAGCTATTCGCCAAGCATCTCGGATGGCACACTGACACCCAACTCGGTACAGCAGCCAAAGTCCGAGGAACAACAAACCGATGAGTCCAAGGCAAATGGTGAAGGTTCTGCTATGGAGCAACAGGAGCTGCCCAAGCCAAAGCGACCTGCTCATTtgcatcatcaccatcatcattatcatcatcagcaggCGCTGAAAATTGCCAACAAGCTGCGCAAAATCAATAAGGAAGCCAAGTTGGCTGCAGCCGCTGGAGCCGGAGCAGGACATGGAGGTGCTGGAACCGGCGCAGCAGCCACCGCCAACAAGTTTGATAAGTTGACAGGCGAAGGCATTAAAAGTCGCAGCGACGGCTCCTATCAGTGTCAGTTCTGTGATAAATCATTTCCGCGTCTCGGCTACTTGAAGCATCACGTGCAGAGCCATGCCGAACATTTGCCTTTCAAATGCGAATATTGCGCCAAGCTATTCAAACATAAGCGCTCCCGAGATCGTCATAAGAAGTTGCATACAAACGAAAGGAACTACAAGTGTCCGCATTGTGAGGCTGCTTTCTCAAGAAGCGATCATTTAAAGATTCATATGAAGACGCACGATATACAGAAGCCGTTTCAGTGCAGCATGTGCAATCGTGGCTATAATACAGCTGCCGCTTTAACCTCCCACATGCAGAAGCACAAGAAGAATGCTGCAATCCTGGCAGCTGGTGGTAATCCCAATGCTCTCAATTATAGTCCACGTTCCACGGGCTCTGCCTCAATCTCTAGCAATGGTAGTCTACACAAGCGTCGCTATGCCTTGGCACTCGCCTCGGATAGCAGTCCAAGTCGTCTGGAGTTTCCCAAGCGAGCTCGTGGTGGTGTAGTACCAACAACGCCTACTCCAACGCCCCTGCTTAGATGCAGTTACTGCAGTCCCAAAGTAATGGAATTCAGCAGTCTGGAGCAACTGAATGCACATCTTCAAGCGGCAcacgaacaacagcagcaacagggaGGCAGAAGCTCTACAACTATTGGCAACAACACGGAGCAAGTGGAACCTTCCACAAATGGTTTTCAACTCAGTTGCGAATATTGCACAATGAAATTTGTGAATATTGCTGCACTCTTTCAACACATGCGAACAACCCATTTGGATCGTTTAAGTAGTCCAAATAGCTACTATGAACACTTTAATCGTCTAGCAACGGCAGGCACATTTAGTCCTCGTTTGGAGATGCCTAAAATCAAGCAGGATCTGCCAAGTCCACCAGCAGAGGAGCTTCCGACGGATCTTAGCAGCAACAAGCGAAGAACCTTAACACCACCAGCGCCACCTGGCGTCTTCTTTTGCAATCAATGCAATGCCGGGCTGCCAGACTTTGAAAGCTTTCGCAATCATCTGAAAACACACATTGCGGAGGGCATGCAAATGATATGTCCTCACTGTGGCTTGAGTCTGCCGGAACAAAGCGAATTTGAACGTCATGTTGTGGCGCATTTTTTAATCACCGGCTCCGAGTTCAATTGTGGCGCCAGTTGTGGCAAATCCTTTACCAAATCGGAGGAACTGCAACAGCATTTAATCAGTGAACATGTTCAGACACTGCTTAAGTGTTCCATTTGCTCGGAGCTGTGTGAGAATCGGATGTCCATGCAGCTCCACTTGGCCTGTGCTCATAGTCAGGAGACGAAGTTGCTTCGGTGCAGTGCGTGCTTGGAACTCTTTCGCAATGATACAGATTTCCATGTGCATGTTAAGACGCGACATCAACTGGTCGGAGGAAGTGCTCCTGCTGGACCGCCCAATGCTACTCCCGCGAATCCCTTGCAGTGCATGTTTTGTCGCGCCGTTTGTGCTTCGGAGCTGGAAATGCATTTCCATTTGGCGGCTCATGCCCGACAATTCCGTTGTCCCAGTTGCCCCGAGACGTTCCATGTGGAGTTCCTGCTCGATCGTCATATGCAGAGTCAGCATGGTGGTGTCAAGGATAAACAGCAGGAGCAGGCCACAAATCCTATGGGCAGTCTGTATGTGAATGCTTTGTTGCCTCCTCTGGCGgctgccgctgcagctgctgctgctgccacaaataataatagtaatctGCATATCGATTACAATGTGGCATTTAAAGGACTCTTTGGTGGAGGCAACTCCACGCCCAACAATACACAGTCAGCGAACAAGTTCTACAGTCCATTGCAGGTCGATACCAGTGCTTTGAAACCACAGCAGACCCCTCATCCCGCACTCATGTACGGTCTTAGTCAACGGTATTTGATGGAGATGTATGCTGCAAAGGCGACTTCACCAGCAGCCAACGCACCCGAACTACCGGCACAAGCAACCcaagcagcaaatgcaacgGCATCCGGTAGCACCGGTAGCACTTACAGTTGTGGCATGTGTGAGCGACAGGATTTACGTAGTGAGGCAGAGCTTCATTCACATCGGAAACTAGCTCATAATCTCAAGACGGGAGTCAGTTTGAGATGTGCCTACTGCTCGGGCAATTATAAGTCTCGTGCGGAGCTGGAACAGCACATGAAGAGCTGTCACAATTCAAGCGGGAAACACAAGTGTCTCATCTGTGACGAGATCTTTCCGTCGCCAGCAATACTTGCCGAGCATAAGCTGCAGCATTCGAAGGTGGGTCAGTCGGGTAAATGTGCCCATTGTGGTCAGCAGTTGGAGCATGTGGCTGCATTCCGTGCACATCTGGGAGAGCATGGTAATGATGGTAATTTACCCATGGCATGCATATGCTGCCGTCAAACTTTACACTCTGAGTTTGAGCTAAGCTTGCATGCAAAGTTCCACACAAAATCTCCAAACAGTGGTAGCCTCCAGGAGCCTGTTTGTGCTCTGTGCTTGGAACCCTTGCCGGAAGCGGGAGAAACTGCCAAATTGTGTGACAAGTGCTGTCGCAAACATAATCTCAATGGTAAGAGAAACAACAAGGAAGCACCTCCAGTGGTAGCTCCTCAACAACCATCAGCAACCACAGTGAATTATCTGGAGAATCGTTGTAATCTCTGCAAGCTCATACTGCCACATGCTCAAAAACTCCAGGAACATCTGGTGGAACATACGTTTGCCGGTACCGAACAGCGTGGTTTCAATTGCTACATTTGCTCAGCGGTATTTACGGCTCCCGGTGGTCTCCTGGCTCACATTGCGGAGCATGGTGCTCGACCCTATGATTGTAATTTGTGTCCAGAGAAGTTTTTCTTCCGTGCCGAGCTCGAGCATCATCAGCGTGCCCATGAACTACGTCAAATCCCAGCAGCACCCAATCCACCACCTTCGGTACGTCCACCACCCAAACAGGAACATCACAGCTCCTCGGCCAGTTCACCCATTCTCAGTCCCAGTCATGTGAAGCAGGAGCTTTATGAATCAGAAACTGCAACCTCaccacaacagcaagaagAGTCACCTGTCCAGGATGACGAGGagtacattgaagttgagcaGGTTCCGCATGAAATCCGTTCCAATGAACTGTTATCCGGCGGACAGACAGAACGCTCCAGCAGCAGTGCCTAA
Protein Sequence
MMALKMLYRGHSSRLENLIEKIQATKEITNNDMYSTHTSSSYSPSISDGTLTPNSVQQPKSEEQQTDESKANGEGSAMEQQELPKPKRPAHLHHHHHHYHHQQALKIANKLRKINKEAKLAAAAGAGAGHGGAGTGAAATANKFDKLTGEGIKSRSDGSYQCQFCDKSFPRLGYLKHHVQSHAEHLPFKCEYCAKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASISSNGSLHKRRYALALASDSSPSRLEFPKRARGGVVPTTPTPTPLLRCSYCSPKVMEFSSLEQLNAHLQAAHEQQQQQGGRSSTTIGNNTEQVEPSTNGFQLSCEYCTMKFVNIAALFQHMRTTHLDRLSSPNSYYEHFNRLATAGTFSPRLEMPKIKQDLPSPPAEELPTDLSSNKRRTLTPPAPPGVFFCNQCNAGLPDFESFRNHLKTHIAEGMQMICPHCGLSLPEQSEFERHVVAHFLITGSEFNCGASCGKSFTKSEELQQHLISEHVQTLLKCSICSELCENRMSMQLHLACAHSQETKLLRCSACLELFRNDTDFHVHVKTRHQLVGGSAPAGPPNATPANPLQCMFCRAVCASELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDKQQEQATNPMGSLYVNALLPPLAAAAAAAAAATNNNSNLHIDYNVAFKGLFGGGNSTPNNTQSANKFYSPLQVDTSALKPQQTPHPALMYGLSQRYLMEMYAAKATSPAANAPELPAQATQAANATASGSTGSTYSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCSGNYKSRAELEQHMKSCHNSSGKHKCLICDEIFPSPAILAEHKLQHSKVGQSGKCAHCGQQLEHVAAFRAHLGEHGNDGNLPMACICCRQTLHSEFELSLHAKFHTKSPNSGSLQEPVCALCLEPLPEAGETAKLCDKCCRKHNLNGKRNNKEAPPVVAPQQPSATTVNYLENRCNLCKLILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLAHIAEHGARPYDCNLCPEKFFFRAELEHHQRAHELRQIPAAPNPPPSVRPPPKQEHHSSSASSPILSPSHVKQELYESETATSPQQQEESPVQDDEEYIEVEQVPHEIRSNELLSGGQTERSSSSA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00538445;
90% Identity
iTF_01321363;
80% Identity
-