Basic Information

Gene Symbol
L
Assembly
GCA_035044485.1
Location
JAWNNV010000457.1:109944-118559[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 9.8e-06 0.00068 19.9 2.9 1 23 160 182 160 182 0.98
2 18 0.34 23 5.6 6.2 1 23 188 210 188 210 0.97
3 18 1.6e-07 1.1e-05 25.5 3.2 1 23 216 238 216 238 0.99
4 18 1.2e-05 0.00083 19.6 0.4 1 23 244 266 244 266 0.99
5 18 0.16 11 6.6 0.1 2 23 340 365 339 365 0.92
6 18 0.013 0.91 10.1 0.5 2 23 398 420 397 420 0.96
7 18 0.026 1.8 9.1 0.7 1 23 485 507 485 507 0.97
8 18 0.005 0.34 11.4 0.1 2 23 515 536 514 536 0.91
9 18 0.0002 0.014 15.8 0.1 1 23 544 568 544 568 0.93
10 18 4.4 3e+02 2.1 0.3 2 20 574 592 573 593 0.91
11 18 4.9 3.4e+02 2.0 1.6 2 23 604 626 603 626 0.95
12 18 0.0024 0.17 12.4 1.1 1 23 672 695 672 695 0.97
13 18 0.0062 0.43 11.1 1.6 2 23 867 889 866 889 0.96
14 18 0.11 7.6 7.2 0.1 1 23 895 917 895 917 0.92
15 18 0.53 37 5.0 0.4 2 23 925 946 924 946 0.93
16 18 0.94 65 4.2 0.5 2 23 1044 1065 1044 1065 0.94
17 18 0.023 1.6 9.3 0.0 1 23 1075 1097 1075 1097 0.96
18 18 0.00048 0.033 14.6 1.3 1 23 1102 1124 1102 1124 0.97

Sequence Information

Coding Sequence
ATGATGGCTTTAAAGATGTTATATCGCGGTCCCAGTTCGCGTTTGGAGAACTTAATTGAAAAGATTCAGGCCACCAAGGAGATTACAAATAACGATATGTACAGCACGCACACCTCCTCGAGCTACTCGCCAAGCATCTCGGATGGCACACTGACACCCAACTCGGTACAGCAGCCAAAGTCCGAGGAACTGCACACAGAAGAGTCGAAGGCAAATGGTGAAGGTACTGCTATGGAGCAACAGGAGCTGCCCAAGCCAAAGCGACCCGCTCATTtgcatcatcaccatcatcattatcatcatcagcaggCGCTGAAAATTGCCAACAAGCTGCGCAAAATCAATAAGGAAGCTAAGTTGGCTGCAGCCGCCGGAGccggagcaggagcaggacaTGGCGGTGCTGGAACCGGAGCAGCCGCCAACAAGTTCGATAAGTTGACAGGCGAAAGCATTAAAAGTCGCGGCGACGGCTCCTATCAGTGTCAGTTCTGTGATAAATCATTTCCACGTCTCGGCTACTTGAAGCATCACGTGCAGAGCCATGCCGAACATTTGCCTTTCAAGTGCGAATATTGCGCCAAGCTATTCAAGCATAAGCGCTCCCGAGATCGTCATAAGAAACTCCATACAAACGAGAGGAACTACAAGTGTCCGCATTGCGAGGCTGCTTTCTCAAGAAGCGATCATTTAAAGATCCATATGAAGACGCACGATATACAGAAACCGTTTCAGTGCAGCATGTGCAATCGTGGCTACAATACAGCTGCCGCTTTAACCTCCCACATGCAGAAGCACAAGAAGAATGCTGCAATCCTGGCAGCTGGCGGTAATCCCAATGCACTCAATTATAGTCCACGTTCCACGGGCTCTGCCTCGATCTCGAGCAATGGTAGTCTACACAAGCGTCGCTATGCCTTGGCACTCGCCTCCGATAGCAGTCCAAGTCGTCTGGAGTTTCCCAAGCGAGCACGTGGCGGTGCAGTACCAACCACGCCCACACCAACGCCCCTGCTTAGATGCAGTTACTGCAGTCCCAAGCTCATGGAATTCAGCAGTCTGGAGCAACTGAATGCACATCTTCAAGCGGCAcacgaacaacagcagcaactgggcGCCAGAAGCGCCACAACTATGGCCAACAACACGCAAGTGGAGCAAGTGGAGCCTTCCACTAACGGTTTTCAACTCAATTGCGAATATTGCACAATGAAATTTCTCAATATTGCCGCACTCTTTCAACACATGCGAACGACCCATTTGGATCGTTTAAGTAGTCCCAATTCGTACTATGAACACTTCAATCGTCTGGCAACCGCAGGCACATTTAGTCCTCGTTTGGAGTTGCCCAAGATCAAGCAGGATCTGGCAAGTCCACTGGCAGAAGAACTACCAACGGATTTGAGCAGCAATAAGCGAAGAACTTTGACACCACCAGCGCCACCTGGCGTCTTCTTTTGCAATCAATGCAATGCCGGCTTGCCAGACTTTGAAAGCTTTCGCAATCATCTCAAAACACACATTGCGGAGGGCATGCAGCTGATCTGTCCCCACTGCGGCTTGAGTCTACCGGAACAAAGCGAATTCGAACGTCATGTGGTGGCGCATTTTTTAATCAGCGGCTCCGAGTTCAACTGTGGCGCCAGCTGTGGCAAATCCTTTGCCAAGTCGGAGGAACTGCAACAGCATTTAATCAGTGAACATGTTCAGACACTGCTTAAGTGTTCCATCTGCTCGGAGCTGTGTGAGAATCGGATGTCCATGCAGCTGCACCTGGCCTGTGCCCATAGTCAGGAGTCGAAGTTGCTGCGATGCAGTGCGTGCTTGGAACTGTTTCGCAATGATACAGATTTCCATGTGCATGTGAAGACGCGACATCAACTGGTTGGAGGCAGTGCTCCTGCTGGACCGCCCAATGCTCCACCCGCGAATCCCTTGCAGTGCATGTTTTGTCGCGCCGTTTGTGCTTCGGAGCTGGaaatgcatttccatttgGCGGCACATGCCCGACAATTCCGTTGTCCCAGTTGCCCGGAGACGTTCCATGTGGAGTTCCTGCTCGATCGTCATATGCAGAGTCAGCACGGCGGTGTCAAGGATAAGCCGCAGGAGCAGGCCACCAATCCCATGGGCAGTCTGTATGTGAATGCTTTGCTGCCTCCTCTGGCggctgccgctgcagctgctgctgctgccaccaaTAATAACAGTAATCTGCATATCGATTACAATGTGGCATTCAAAGGACTCTTTGGTGGAGGCAACTCCACGCCCAACAATGCAGCGGCAGCGAACAAGTTCTACAGTCCATTGCAGGTCGATACCAGTGCTTTGAAGCCACAAACAACCCCACATCCCGCACTCATGTACGGTCTTAGTCAACGGTACTTGATGGAGATGTATGCAGCAAAGGCAACTTCACCAGCAGCCAGTGCACCCGAACTACCGGCACAGGCAACCCAAGCGGCAAATGCAACGGCCTCCAGCACCGGAAGCAGTTACAGCTGCGGCATGTGTGAGCGACAGGATTTGCGTAGTGAGGCAGAGCTCCATTCACATCGGAAACTGGCGCATAATCTCAAGACGGGAGTCAGTTTGAGATGTGCCTACTGCTCGGGCAACTATAAGTCTCGTGCGGAGCTGGAACAGCACATGAAGAGCTGTCACAATTCCAGTGGGAAACACAAGTGTCTCATCTGCGATGAGATCTTTCCATCGCCAGCCATACTGGCCGAGCATAAGCTGCAGCATTCCAAGGTGGGTCAGTCGGGTAAATGTGCCCATTGTGGCCAGCAGTTGGAGCATGTCGCTGCATTCCGTGCACATCTCGGAGAGCATGGTAATGATGGTAATTTGCCCATGGCATGCATATGCTGCCGTCAGACTTTACACTCCGAGTTTGAGCTAAGCTTGCATGCCAAGTTCCACACAAAATCGCCAAACTGTGGTAGCCTCCAGGAGCCTGTGTGTGCTCTTTGCTTGGAGCCCTTGCCGGAAGCGGGAGAAACTGCCAAGTTGTGCGACAAGTGCTGTCGCAAACATAATCTCAATGGTAAGCGAAGTAAGGAAGCAGCTCCAGTGGTAGCTCCCCAACAAGCGTCAGCAACCACAGTTGGTTATGTGGAGAATCGTTGTAATCTGTGCAAGCTCATATTGCCACATGCTCAAAAGCTGCAGGAACACCTGGTGGAACATACGTTTGCCGGTACCGAACAGCGAGGTTTCAATTGCTACATTTGCTCAGCGGTATTCACGGCTCCCGGCGGTCTCCTCGCTCACATTGCGGAGCATGGTGCCCGGCCTTACGATTGTAACTTGTGCCCCGAGAAGTTTTTCTTCCGTGCCGAACTCGAGCATCATCAGCGTGCCCATGAACTACGTCAAATACCAGCAGCACCCAATCCACCTCCTGCGGTACGTCCAACACCCAAACAGGAGCATCACAGCTCCTCGGCCAGTTCACCCATTCTCAGTCCCAGTCATGTTAAGCAGGAGCTCTATGAATCAGAAACTGCCACCTCACCGCAACTGCAAGATGATGAGTCCCCTGTCCAGGACGAGGAGGAGTACATTGAGGTCGAGCAGGTTCCGCATGAAACCCGCTCCAATGAACTGCTGTCCGGCGGACAGACCGAACGCTCCAGCAGCAGTGCCTGA
Protein Sequence
MMALKMLYRGPSSRLENLIEKIQATKEITNNDMYSTHTSSSYSPSISDGTLTPNSVQQPKSEELHTEESKANGEGTAMEQQELPKPKRPAHLHHHHHHYHHQQALKIANKLRKINKEAKLAAAAGAGAGAGHGGAGTGAAANKFDKLTGESIKSRGDGSYQCQFCDKSFPRLGYLKHHVQSHAEHLPFKCEYCAKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASISSNGSLHKRRYALALASDSSPSRLEFPKRARGGAVPTTPTPTPLLRCSYCSPKLMEFSSLEQLNAHLQAAHEQQQQLGARSATTMANNTQVEQVEPSTNGFQLNCEYCTMKFLNIAALFQHMRTTHLDRLSSPNSYYEHFNRLATAGTFSPRLELPKIKQDLASPLAEELPTDLSSNKRRTLTPPAPPGVFFCNQCNAGLPDFESFRNHLKTHIAEGMQLICPHCGLSLPEQSEFERHVVAHFLISGSEFNCGASCGKSFAKSEELQQHLISEHVQTLLKCSICSELCENRMSMQLHLACAHSQESKLLRCSACLELFRNDTDFHVHVKTRHQLVGGSAPAGPPNAPPANPLQCMFCRAVCASELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDKPQEQATNPMGSLYVNALLPPLAAAAAAAAAATNNNSNLHIDYNVAFKGLFGGGNSTPNNAAAANKFYSPLQVDTSALKPQTTPHPALMYGLSQRYLMEMYAAKATSPAASAPELPAQATQAANATASSTGSSYSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCSGNYKSRAELEQHMKSCHNSSGKHKCLICDEIFPSPAILAEHKLQHSKVGQSGKCAHCGQQLEHVAAFRAHLGEHGNDGNLPMACICCRQTLHSEFELSLHAKFHTKSPNCGSLQEPVCALCLEPLPEAGETAKLCDKCCRKHNLNGKRSKEAAPVVAPQQASATTVGYVENRCNLCKLILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLAHIAEHGARPYDCNLCPEKFFFRAELEHHQRAHELRQIPAAPNPPPAVRPTPKQEHHSSSASSPILSPSHVKQELYESETATSPQLQDDESPVQDEEEYIEVEQVPHETRSNELLSGGQTERSSSSA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00538445;
90% Identity
iTF_01322102;
80% Identity
-