Basic Information

Gene Symbol
zfh1
Assembly
GCA_035044645.1
Location
JAWNNT010000134.1:18651147-18655339[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 2.8e-05 0.0019 18.5 1.0 1 23 139 161 139 161 0.97
2 15 0.17 11 6.6 3.0 3 23 169 189 167 189 0.89
3 15 9.4e-05 0.0063 16.9 0.1 1 23 368 390 368 390 0.98
4 15 0.00098 0.065 13.7 1.0 1 23 396 418 396 418 0.98
5 15 3.6e-05 0.0024 18.2 2.2 1 23 449 472 449 472 0.95
6 15 0.0013 0.089 13.2 1.1 1 23 516 538 516 538 0.95
7 15 0.018 1.2 9.7 1.3 1 23 544 567 544 567 0.97
8 15 0.028 1.8 9.1 0.4 3 19 576 592 575 593 0.95
9 15 0.00016 0.011 16.1 5.6 1 23 602 624 602 624 0.97
10 15 0.043 2.8 8.5 1.2 2 23 630 651 629 651 0.96
11 15 9.6e-06 0.00064 20.0 1.0 1 23 660 682 660 682 0.98
12 15 0.0011 0.072 13.5 0.1 3 23 690 710 688 710 0.97
13 15 5.8e-05 0.0039 17.5 0.5 1 23 716 738 716 739 0.95
14 15 0.024 1.6 9.3 0.5 1 23 749 771 749 771 0.97
15 15 0.00017 0.012 16.0 0.5 1 23 1293 1315 1293 1315 0.98

Sequence Information

Coding Sequence
ATGAACAACCAGGATTATGGTGGAATCCATTGGATACAACAGGAAACCAGCGCCGCCGACGACACCGACAGCGAGGTGACTGCCGCCTATTTAGTGAACGGCAATGCCACCGACGAGGATCTTGACCATATGGCAGCTGAAAACCTCATCTTTATGCGTGACGGTCAACTCAGCGAGATCATCGAAGCGAATGAGGCTGCCGGCACTGTGTTGATCACAGACAGCGGCAACGTTGCCTATGCGGAATcctttgatgatgatgctcaGGTTGTCACTGAGGAAATCATTACCGATGACTGGGTGCAGCATCAAGGGGCAGAGCGtgTGGTAATTGCGGCGGAGCAGATAGCTGGCAATGGCAGTTCTCAGGAACTGTTGGATATGCAGCAAAATGAGTATATGGCCATGCGTCCGTATCCCTGCGACTTTTGTAGTCGTCGCTTCCGCAAGAAGGCCAGTCTCAATAATCATATGCTAGCGCATCAGAATGATCGTCCGCATCTGTGCAAGTTGTGTGGAGCGCGTTTCTCGCGACGCGCCGAGCTAATATGTCATTTTAAGGCTCATGCCGAAGCTCAGGCAGATGAAGAGgctgccgctgcagccgcGGAAGCTGCTGCAATTAAATTcgaaccacaacaacagcagcacctacagcagcagcgacaactcAACGATCATTTCTATGAACAAGAATGGCCGCTTTATCATGACCAAGAACACGAACAAGACCAAGCGCATGAACAGGAGCTCGAACAGGTGCAGGTGCAGGTGGAGCATGAGCATGAGCAGGACCAACTAGTCGTCCAACAGGCCAGCTATGCAGCAGTCAGCGCTGTGGCAGCACCAACAGCTGCTCGAGGTCGCATCAGTCGGCTCAAACTTAAAGAGGAAAGCACTCAATACATTGTGATGGCTGAAAAGCAACAGACTCCCGAAAATGCCGAATTGCGGCAGTATATGGACTGCGAGGAGCTCAACCAACCGCTTGCTACAAACACCACATCAAACGATGCAACACACTCACTTCTCGATAGTCAACTTGCTTCCGATGGGGCACAACAAACTTTACGCTATCCTGTACTAGATGAGAGTAAGCCATTTGTCTGCCAACAGTGTGGATTGGCATTTGCTCGCGAGAAAGCTCTCGTCTCCCACATCAAGAATCATCGGGTGGACTCGCCGTTCGAATGCAATCAGTGTCAGGAGATGTTCTGGGATAATTTTAGCCTGCAGGAGCACCAGAAGACACACCAATTTGAGGAGAGTAATTCGGAATATGATCCTGCATCGGCTGGGGAGGAAAGTGTCAGTGAATCGGAGCCAGATCAGCTATACGGTGACTTCTACTGCAGCGAATGCGGCATCTCCTTTCACCGGCAAGATCTGCTTCGTCGCCATGCCAAGCAGCAACACAGCAAGCATCCAGCAACAGCTGACAATAATGGTGTAACGTCCACAGATGCAGAGGCTGGAggcgatgatgatggtggtggcgctggagttggagttgaagCTGATGACGAGAATGCCAAAGATGCACCACACAGTTGTCATACATGCGGCAAATCATTTCCAACCGTGCTAAAACTTCTTGCACATGCGGAAATTCATAGACGTTTCCCGCCATTCAAATGTGTCCTGTGTGGCGTTAGCTTTTACGAGGAGCAGGCAATTAAACGCCATTTGCACACACGACATCCGCACGAGCTGAAGCCAAATTCTTGCGTGCTGTGTGGAAAGGAGTGTCGCGATCGTAAGGCCCTGATCAAGCATGCCTGGGATCATTCGCGTGAAAAGTGCCACTCGTGCTCCAAGTGCGGCAAGAACTTTCATAATAAGGCGCGACTCAAGAGGCACATGGCGTCGCATCGCGACAAGTCGGTGGTGTGTGAGGTGTGCCACGAGGAGTTTCCTGATGGACGCACCTTATCCAATCATCGGCATTCGCATAGCACAACGTCGCCGGGTAAACTGTTCCCCTGCCACGAGTGTGGCAAGACCTTTGGATCGCGCAGTTCACAGCAGATTCATGTGCGTATTCATACGGGCGAACGTCCTTATGGCTGTCGCTATTGCTGGAAAGCTTTCGCCGATGGTGGCACATTGCGCAAGCATGAGCGAATCCACACTGGTGAGAAACCCTATGCATGCTCTGTTTGTCCGCGTGCCTTCAATCAACGCGTCGTGCTGCGTGAACATATACGTTCGCATCACTCAGGCTTGGATGCAGCACGTGGCACCTATCATTGCACTGTCTGCTCTGCAGACTTATCCTCATCCAATGACCTCATCAAGCATCTCATTCAACACAGCGATACAAACACTGCGAAACAACGACAACCAATTACTGGTCCTCGCAAGTATAAGCGTCGAAGGAAACTGCAACCGCATGAGATTGCGCACATGCGCGAACGCGAGGAGTATGCCAGTGATATGGAGTACTGCGATTTGGATGTGGAGAATGTCGATGATCTGCTTGATAGTGCGGAACCATCACTAGCAAAGAAGGAGAAGCGCAAACGCAATGCAGCCAGTAAAACAGTTAACCAGAGCAATGGTGTAGAAGCTCCCAGCTCGctcaataaatcaaatgccaaaagcagTTCGGATCGCCTGTGGGATGAGAAATTCATGCAATCGAATGGTGGCAATGGGACTCAATTGAATAATGATGATGCATACAAAAGCGTATTCCACATTGATTCTCTTGTGGTTGTCAATGATACGGCATTGCAGCCAGTGAGCACGACCAGCGTTGCAGGCGGTGCCACAAAGTCAAGGCGTGGCGGCAAACAAACGCAGATGCAGGCCGACGAGTCGACCAAATTGGGAAATATTTCAAGCAGTCGCCAGAGCAATAAAAAGAGATCTGGCAAAGCACAGACCACAACAAcctcatcagcagcagcagccggcgcagcaggcagcagttcATCACGTCCCCGCATGATACACACTGAAAAGTCACGTCTGCCCCCCGACACAAAGAAGTCGCGGGGGGCAAATCGCAGTTATATCACACGCACCAATACCAACGCAAACGAACAGCAGAGCAattgcaccagcagcagcagcctggTTAAGTCGACTTCGCGTATTGTGGATGACTACGAGATTATATCACCTGCCACACAGCCACCAAATCAAATCAGTTCCAGTCCGTTGCATATTAAACAGGAGCAGGAACACCATCATCAGCAGCGCGTCCAGCTTATGTACGATGATACACATTTGCTGATTGATGCGGGCCTGTTGCGTGAAAAGACGTACGAGAAGTTCAATCCGAGCATTGTCAATGATCTGGAAGAGATATTGCGTAGTCCGCTTAAACATGATCGCAACGCGCGTCTACGTTTCACCAGCGAATCATCAACGACGCCACAGTTTCTGCCCGAGGAGGAGCAGAACTTAATAAAGATTGAGCCAACGTCACCAGATCTGCGCGAAATGGTGGAGAGTCAACAGCGTGTGTCTGCGACAGGAAACACTACTGCCACATCATTGTCCTCATCCTCATTATCATCAGCGCGTACCTCATCGCGCCACCTGCGACAACTAACTGCCAATGGTTCTGAGACTGGGTGCAGTTCAAGGGCAGGTACTAAacgcagcggcagcaaacaGGTGTCAAGTGCAACCAGCTCCAAGAAATCGACATCAACATCTTCAATTGGCAGTAACAGCAAAACCAATTCCTACCTCAGCAGTTATGGCGTGGACTCGTACAATGTACAATGTGTGGCGGGCAGCACCAACTCTTCGGATGTCAGTTCCGGTTTCTTTTCCATATCCGAGGTGGTATCTGCTGCGGATGCCGCCGATGCAGCAGCCAAAGCCGCAGCGGCCTGCAAAACGGAGCGGCGAGCCCGATGCTTtgaatgtgaaatgtgttCGTACAATTTTCCCGATCGTGCCCAACTTCTAgagcatatgcatatacacatCTAG
Protein Sequence
MNNQDYGGIHWIQQETSAADDTDSEVTAAYLVNGNATDEDLDHMAAENLIFMRDGQLSEIIEANEAAGTVLITDSGNVAYAESFDDDAQVVTEEIITDDWVQHQGAERVVIAAEQIAGNGSSQELLDMQQNEYMAMRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELICHFKAHAEAQADEEAAAAAAEAAAIKFEPQQQQHLQQQRQLNDHFYEQEWPLYHDQEHEQDQAHEQELEQVQVQVEHEHEQDQLVVQQASYAAVSAVAAPTAARGRISRLKLKEESTQYIVMAEKQQTPENAELRQYMDCEELNQPLATNTTSNDATHSLLDSQLASDGAQQTLRYPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNFSLQEHQKTHQFEESNSEYDPASAGEESVSESEPDQLYGDFYCSECGISFHRQDLLRRHAKQQHSKHPATADNNGVTSTDAEAGGDDDGGGAGVGVEADDENAKDAPHSCHTCGKSFPTVLKLLAHAEIHRRFPPFKCVLCGVSFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIKHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMREREEYASDMEYCDLDVENVDDLLDSAEPSLAKKEKRKRNAASKTVNQSNGVEAPSSLNKSNAKSSSDRLWDEKFMQSNGGNGTQLNNDDAYKSVFHIDSLVVVNDTALQPVSTTSVAGGATKSRRGGKQTQMQADESTKLGNISSSRQSNKKRSGKAQTTTTSSAAAAGAAGSSSSRPRMIHTEKSRLPPDTKKSRGANRSYITRTNTNANEQQSNCTSSSSLVKSTSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHHHQQRVQLMYDDTHLLIDAGLLREKTYEKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVSATGNTTATSLSSSSLSSARTSSRHLRQLTANGSETGCSSRAGTKRSGSKQVSSATSSKKSTSTSSIGSNSKTNSYLSSYGVDSYNVQCVAGSTNSSDVSSGFFSISEVVSAADAADAAAKAAAACKTERRARCFECEMCSYNFPDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01320605;
90% Identity
-
80% Identity
-