Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_018904305.1
Location
JAEIGR010000001.1:7397112-7401529[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.2e-22 1.6e-18 66.2 0.1 4 76 455 525 452 526 0.93
2 2 0.7 2.7e+03 -1.8 0.0 37 50 746 759 745 760 0.85

Sequence Information

Coding Sequence
ATGGGACGTCGTTGCTGCGTTTCTGAATGTCCGTCTACATCGCGGCTTTTAGAGCACCATGGCGTCACTTACCACTCGTTTCCCATGGACCCCGTCATACGTGCCATTTGGATAAAGAACTCGCGCACCAGTCTCGACAGACAAATTACAAAGAGTGTGCTTGTTTGTTCGCGTCACTTCCGACGTCTCGATTTTAATACAGTGCGCAATGGTAAATATTTGCTAAAACCGCGCGTTTTTCCCACTGTATTCCCATGGGGCAAAATGGATCCTGCCGAAATCGAGGCGGATCAACGGGCATTGCAACAAGCAACGGTCGATGGCTTAGGGGTCAGCGGTGCCGCTAACAGTGCTAGCAGTGAGGACCTAATTAAGGCAACTGTTGATCAAATTGTTGCCCAAATACATGCAGAGACTGCCGAGCGAAATGCAGCGGCTGCCGCTGCAGCTGAGGCAGCAGCCAAAGATGAAGCTGAAGCCCAGTCTAATGCTGTCAAAGAAGTTACCTCTACGGCGCCGGCTGCTGCCGTTGTTTCTGTTGAGAGCAAAGCTGATGCAACTGTTTCAAATGACGCCGCTGCCGACACAGCTGAGGCAGCTAATGATACTCGTCCAGACACTAGCAGCACCAATTCACCGGTGTCTGTCACACCCTCCAAATATGGACCACCCACAAATTTGACGATTGGCGCACGCCTCGAGGCACTAAGCGTCGATGGCGCCTGGCTAACAGCACGTATCGTCGAAATTAACAACACAGAGCAGACGATTCTTATACGCTTCGAACGCAACAGCAAGCTTAAGTCGATGCCCTCAACAAACGGCAGCTACCAGGAATGGATAGGATTCAAATCGGATCGTTTACGTCAGCGCATCTGCTTGCGCGTGCTTCCGGTCTTTAAGCTGGAGGAGAAGTGCATGGCGCGCTGGTCGGGACCACGCAAATTTCCGGGTACCATCAAACAAATATTGGGAAACGATACCTACGAGGTGCTCTTCGATGATGGCTACACAAAGAATGTTCGCGCCGTTCACATGAACAAGTTGCCACGCCAGTTGCTTACTGCGAGTGCAGAGGCAACCACTGAATCCACTAGTACTGAATCTGCTGCAGAGTCAGCTCCAGTTCCAGTTGAAGCTGGTGTAAAAAGACCGAGCTCAGGTCCAACAAGTAGCAAGAAGAAGAGTAAGACGACACCACAACGCAAGGACTGGCCATTGCTGGATATGTCCAACTTGGATTTAGCTGCACTTGGACTCCCCGATATACCGCATGACGGTGAATGGACCTGTCATTGGGTAAATGATCAGCCGATTGGCAACGAAGGATTTCTTATTGTTGGTGAGCATCAGAAGCCAACGGTGATTGTCCACGATTGGCGACTGCCGGAAGGTTGGATTAAGCACATGTACCAACGCTCCAATGTGTTGGGCAAGTGGGATGTCATTTTGGTGTCGCCCAGTGGCAAACGTTTTCGCTCCAAGTCCGATCTCAAAGTGTTTTTGGAGTCGCAAGGGAAGATTTACAATCCGGATGTGTACGATTTTAGCATTCACCGTCGACGTGCCAAGGACATAAATGCCTATGTCTACACACACGACTACAGTCCACAGCAGCCGGTCAAACCGAAGTCAATGGATGTGTCTTTGGATACCACTGCAACATCGCAAGATCTTAACAGCAGCAAGTTATCAACTGCTACGCCCATAGCGGCAATGTCTACGCGACGCACTGCAGCAGATGAGAGTCAGTACATGGAAACGCCAGTGGCCTCATTGGTACCGCCAGCGGAGCTGATGTCGCCAACGCCACAAGCCCAAGCAGTTGAGCCTCTGCCATCCACAACTCATGCAGCTGAAATCAGCTCAGCTCTGAGCGGTGAAGAGCCAGCCCGCGTCGTTGTCGAAGACGGCTACGCCTTTATTGGCGGTTTGAAAGTTCAAATAACCGACAATTTGTTTGTTTGCCCACGTGAGGGTTGCGGCAAAACCTTCCGAAAAGAGGACTTCTTACAAATTCATATACGCCACTATCACAAGGAACTTGCCGAGCACGTCAGTCACTGTCCCAAGATGCAGGAGCTGGCCGTTAAGCGCACACATCCCTCATCGATTGAGCAGGGCGATCAGACGCCGAAAAATCAAATACCAAACCAGCAATTCTTTGCCAAGCTACACCAGCAGGACTTACAGCAATCTCGCTCTTTCCGACGCAACCCTGCGGCTATTGAAACATCGCCAACAGGTCAGGACGCATCTTCACATAATTCGCCTATCAATGCAAGCATATCAATCAAAACGGAACCGCCAACGACTCCAAGATCTGTGCCGCAATCAGTTGTAGTCTCGCCAGAAAATGCTACTGGGCCTTCGACCGCTGAAACTGCGAAAACTGCGCTATTAAACCAGACAATAACCGCAACACCAGTCAACTCGCCGTCATCCAATCGATCCGGCAAACGTGCGCGTCCTTCATCTAGAAGACGCCCTTCCGGATCCCGTAAGAGCAGTCGTCAACGCTTACAGCGCCGTCCTGTAAATGAACAAAAAAGAATTCCTGCTGCTGTTGGTAACACGCGCAGCTTGCCAGTGGCGGGAGCGGACACCGAGTCTACTGGACTGTCATATAGCACGCCAGTGCCGGAGGTACGCAACGATCCCAAAAAGCGACGCATTGCAGCTTCCGGAACACCTTCCGGCTCACCTGCTAACATGGATTTGGTGCCGAGGTCGTCATCAAACGATATGGTTGACATAAATGCAGCTTTGCCGCCACCGCCTACGCCATTGGCCAGCCAAACGCCGCAGTACATTAAGGAGAATGGCGAATTGATACGCATTGTTCGGATGCGGCAGGAGGAAATTATTAGTTGTATTTGCGTATATGGTGAAGAGGATGGTTTGATGATACAATGTGAACTATGTCTGTGCTGGCAGCATGGCGGCTGCCATGGAATTGTCAAAGAGTCAGACGTACCGGAAAAGTATGTCTGCTATATTTGCCGCAATCCACAGCGTGTGCGGGATTCGATGCGCTACAAACATGATCAGGACTGGCTGTTTGAAGGCAAGCTGCCCGTGGCTGGTTATCACACGCCTAATCTTCAGGCTGCCAAAAAGTTCGAGCTATTAAAGCATTCACACACCTTGACTGGAAATTTACTAGATGCTAAACGGTTGATGCACTCGCTGCAGGTCAAGATCAATATTGCTCGCAATCGTTTCCACCCGAAGCTTTATCTTTGGGCCAAGAAGTGGGACGAGGATCTAACAGATGCGTCTGTCACGCCTGTAAAGCGTCAAAAGGTTGAACCACCTGGTTTTCCGCATGCACCACAACCGGAGGCTGCTATCGATCCCGAAGAGTGCCAGTATCGTTTAATTGATCACATCAAAATACAACAATCGCTCTTGGCGAAAAGGCTCGATGACATTGAAGCCGAAATGAATGATCTTGAAAACGAAGATACTTTGCCCGATCTAAAAGAATCTAACTTTTCGACAACTACAGAAGCCTTAGCTACATACATTAAAGAGCTGGGTACAATGAAACGGTTGGCAAAGCTTAACAACGTGGCTAACATGAAGCAGTCCCTAAAGGACCAAGAATCAGCGTCTCAAGCTTAA
Protein Sequence
MGRRCCVSECPSTSRLLEHHGVTYHSFPMDPVIRAIWIKNSRTSLDRQITKSVLVCSRHFRRLDFNTVRNGKYLLKPRVFPTVFPWGKMDPAEIEADQRALQQATVDGLGVSGAANSASSEDLIKATVDQIVAQIHAETAERNAAAAAAAEAAAKDEAEAQSNAVKEVTSTAPAAAVVSVESKADATVSNDAAADTAEAANDTRPDTSSTNSPVSVTPSKYGPPTNLTIGARLEALSVDGAWLTARIVEINNTEQTILIRFERNSKLKSMPSTNGSYQEWIGFKSDRLRQRICLRVLPVFKLEEKCMARWSGPRKFPGTIKQILGNDTYEVLFDDGYTKNVRAVHMNKLPRQLLTASAEATTESTSTESAAESAPVPVEAGVKRPSSGPTSSKKKSKTTPQRKDWPLLDMSNLDLAALGLPDIPHDGEWTCHWVNDQPIGNEGFLIVGEHQKPTVIVHDWRLPEGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKVFLESQGKIYNPDVYDFSIHRRRAKDINAYVYTHDYSPQQPVKPKSMDVSLDTTATSQDLNSSKLSTATPIAAMSTRRTAADESQYMETPVASLVPPAELMSPTPQAQAVEPLPSTTHAAEISSALSGEEPARVVVEDGYAFIGGLKVQITDNLFVCPREGCGKTFRKEDFLQIHIRHYHKELAEHVSHCPKMQELAVKRTHPSSIEQGDQTPKNQIPNQQFFAKLHQQDLQQSRSFRRNPAAIETSPTGQDASSHNSPINASISIKTEPPTTPRSVPQSVVVSPENATGPSTAETAKTALLNQTITATPVNSPSSNRSGKRARPSSRRRPSGSRKSSRQRLQRRPVNEQKRIPAAVGNTRSLPVAGADTESTGLSYSTPVPEVRNDPKKRRIAASGTPSGSPANMDLVPRSSSNDMVDINAALPPPPTPLASQTPQYIKENGELIRIVRMRQEEIISCICVYGEEDGLMIQCELCLCWQHGGCHGIVKESDVPEKYVCYICRNPQRVRDSMRYKHDQDWLFEGKLPVAGYHTPNLQAAKKFELLKHSHTLTGNLLDAKRLMHSLQVKINIARNRFHPKLYLWAKKWDEDLTDASVTPVKRQKVEPPGFPHAPQPEAAIDPEECQYRLIDHIKIQQSLLAKRLDDIEAEMNDLENEDTLPDLKESNFSTTTEALATYIKELGTMKRLAKLNNVANMKQSLKDQESASQA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01323413;
90% Identity
iTF_01324154;
80% Identity
iTF_01324154;