Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.008 79 3.6 0.5 21 47 6 32 3 39 0.79

2 6 0.00034 3.4 8.0 0.1 24 45 42 63 32 67 0.86

3 6 0.021 2.1e+02 2.3 0.1 27 44 127 144 122 151 0.88

4 6 2.1e-05 0.2 11.9 0.1 26 45 159 178 151 182 0.89

5 6 0.018 1.8e+02 2.5 0.2 23 52 237 266 225 270 0.78

6 6 5.6e-05 0.55 10.5 0.4 27 52 274 299 268 301 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.008	79	3.6	0.5	21	47	6	32	3	39	0.79
2	6	0.00034	3.4	8.0	0.1	24	45	42	63	32	67	0.86
3	6	0.021	2.1e+02	2.3	0.1	27	44	127	144	122	151	0.88
4	6	2.1e-05	0.2	11.9	0.1	26	45	159	178	151	182	0.89
5	6	0.018	1.8e+02	2.5	0.2	23	52	237	266	225	270	0.78
6	6	5.6e-05	0.55	10.5	0.4	27	52	274	299	268	301	0.89

Coding Sequence: ATGCTGGAAAACGCGAGCGGTAAACCCTTTAGATGTGACCAATGCAGCTATACCTCAAATCGTTCCTTCGACCTGCGACGGCACAAACAGCGTCATACCCGCACCAAGCCCATCATTGATGATGGCCATACATGCAGCCAGTGTGAATTTATCACCAAGTGGAAACGCAATTTAAAACGCCACATGCAAACACATATTAAAATGGAAGACTCAGAAGGGGAGCAAATAATTGAGGAGTTCATGGTGGAGGTGCTTGAGTCCTCAGAGACGGAACCCGACAAGTATATGGTGGGAACAGAAACAGAATTTATCATAGAATCACCAGCAGATCAAACTAACAACGAGCCACAAGTAGACAAAGGGCCACGGATCTTTAAGTGCGATCTCTGCAACTATACATCCAAACGCTCCTTCGACCTTCGACGTCATAAGCAGACGCATTCAAAAGTTAAGATCGTTGAAGACGGGGCTCACAAATGCCCAAAATGCTTGTTCGTTACAAAGTGGAAACGTAATATGAGAAGACACATGCACACACACGAAAAAGACCGTGGTGAGGAAGAGGAAGACGAAGAAGAAGAAGAAGAAGAGGATGCACAACAAACGGATGATCTGTCAACTATGGAGTATACAATAGAGCTATTGGAACCAGACGAAGTCTATATGTTTACGATTTCGAAGTCGCAGGACGGTCAACGTTATCTCGAAAAACATTACAGATGCCCAGATTGCGAATATGAAACTAAACGCATAACCGACATGCGACGTCACAAACTGAAGCACCTCAATGCGAAGCCAGTAGAAGGAATAGCCTATCAATGCACCGAATGTTTGTTCATAACTAAATGGAAACGAAATATACATCGCCACATAGAGCAAAGGCACAAGAATACTCCAACTGCACGCAAATTGACAGATGAGGACTTATGTAAAGCTTTTGTTGATCAACAGTCGGATATGCACTCGCAAGAGGAAGAAATTGAGGCCTTAGAGATTGAGGAGGAAAAGAATCCCGAGGTACTGCCAAGCCTTTGGATTGCCCTACCGTTGGAAGATGCATAG
Protein Sequence: MLENASGKPFRCDQCSYTSNRSFDLRRHKQRHTRTKPIIDDGHTCSQCEFITKWKRNLKRHMQTHIKMEDSEGEQIIEEFMVEVLESSETEPDKYMVGTETEFIIESPADQTNNEPQVDKGPRIFKCDLCNYTSKRSFDLRRHKQTHSKVKIVEDGAHKCPKCLFVTKWKRNMRRHMHTHEKDRGEEEEDEEEEEEEDAQQTDDLSTMEYTIELLEPDEVYMFTISKSQDGQRYLEKHYRCPDCEYETKRITDMRRHKLKHLNAKPVEGIAYQCTECLFITKWKRNIHRHIEQRHKNTPTARKLTDEDLCKAFVDQQSDMHSQEEEIEALEIEEEKNPEVLPSLWIALPLEDA

Sequence clustering based on sequence similarity using MMseqs2