Basic Information

Insect: Scaptomyza graminum
Gene Symbol: MBD-R2_1
Assembly: GCA_018901835.1
Location: JAEIFL010000290.1:763407-767688[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 4.3e-22 1.3e-18 66.1 0.1 4 76 468 538 465 539 0.93

2 2 1.6 5e+03 -3.0 0.0 37 48 759 770 758 773 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	4.3e-22	1.3e-18	66.1	0.1	4	76	468	538	465	539	0.93
2	2	1.6	5e+03	-3.0	0.0	37	48	759	770	758	773	0.81

Sequence Information

Coding Sequence: ATGGGACGCCGCTGTTGCGTTGCTGAATGTCCGTCAACATCGCGGCTTTTAGAGCACCATGGCGTCACTTACCACTCGTTTCCCATGGACCCCGTCATACGTGCCATTTGGATAAAGAACTCGCGCACCAGTCTCGACCGACAAATCACAAAGAGTGTGCTTGTTTGTTCGCGTCACTTCCGACGACTCGATTTTAATACAGTGCGCAACGGTAAATATTTGCTAAAACCGCGCGTTTTTCCCACTGTATTCCCGTGGGGCAAAATGGAACCCGCCGAAATCGAGGCGGATCAACGGGCATTGCAACAAGCAACGGTCGATGGCTCTGGGGTCAGCGGTGCCGCCAACAGTGCCAGCAGTGAGGACCTAATTAAGGCAACTGTTGATCAAATTGTTGCCCAAATACATGCAGAGACCGCCGAGCGAAATGCGGCCGCTGCCGCCGCAGCTGAGGCAGCAGCCAAAGCTGAAGCTGAAGCCCAGGCAAATGCTGTTAAAGAAGGTACTGGAAAAATCGAAGCGTCTACCTCTGCGGCGGCGGCGGCTGCTGCTGCTGCTGTTGTTTCTGTTGAGAGCAAAGCTGATGAAACTGTTTCCGATGACGCCGCTGCCGGCACAGCTGAGGCAGCCAATGAAACGCTGCCAGACACTAGCAGCACCAATTCACCGGTGTCTGTCACACCTTCCAAATATGGACCGCCCACCAATCTGACGATTGGCGCACGCCTCGAGGCACTAAGCGTCGATGGCACCTGGCTGACGGCACGCATCGTCGAAATCAACAACACAGAGCAGACGCTTCTTGTACGCTTCGAGCGCAACAGCAAGCTCAAGTCGATGCCCTCGTCAAACGGCAGCTACCAGGAATGGATGGGAGTCAAATCGGATCGTTTGCGTCAGCGCATCAGCTTGCGCGTGCTGCCGCTCTTCAAGCTGGAGGAGAAGTGCATGGCGCGCTGGACGGGACCACGCAAATTTCCGGGCACCATCAAAAAAATATTGGACAACGATACCTACGAGGTGCTCTTCGATGATGGCTACACCAAGAATGTGCGCGCCGTTCACATGAACAAGTTGCCACGCCAGTTGCCCACGGCGAGTGCTGAGGCAACCACTGGATCCACTCATACGGAAACTGCTGCCGAATCAGTTCCTGTTTCAGTTCCAGTTGAATCTGGTGGTGTTAAAAGACCAAGCACCGGATCAACCAGTAGCAAGAAGAAGAGTAAGATAACACCACAACGCAAGGACTGGCCACTGCTGGATATGTCCAACTTGGATTTAGCTGCACTTGGACTGCCCGATATACCGCATGACGGTGAATGGACCTGCCATTGGGTAAACGATCAGCCGATTGGCACCGAAGGATTTCTTATTGTTGGTGAGCATCAGAAGCCAACGGTGATTGTTCACGATTGGCGACTGCCAGAAGGTTGGATTAAGCACATGTATCAGCGCTCCAATGTGTTGGGCAAGTGGGATGTCATTCTGGTGTCGCCCAGTGGCAAACGTTTTCGCTCCAAGTCCGATCTCAAGGTGTTTTTGGAGTCGCAAGGAAAGATTTACAATCCGGATGTGTACGATTTTAGCATTCATCGTCGACGCGCCAAGGACATAAATGCCTATGTCTACACACACGACTATAGTCCGCAGCAGCCGGTCAAACCGAAGCCAATGGATGTGTCCTTGGATTCCACTGCAACATCGCAGGATCTGAACAGCAGCAAGTTATCAACTGCTACGCCCATAGCGGCAATGTCTACGCGACGCACTGCAGCAGATGAAAGTCAGTACATGGAAACGCCAGTTGCCTCTTTGGTGCCGCCAGCGGAGTTGATGTCGCCATCGCCACAAGCCCAAACACTTGAGCCTCTGCCATCCGCAACTGAAGCAGCTGAAATCAGCTCAGCTCTGAGCGGTGAAGAGCCTGCCCGCGTCCTTGTCGAAAATGGCTACGCCTTTATTGGCGGATTGAAAGTTCAAATTACCGACAATTTGTTTGTTTGCCCGCGTGAGGGATGCGGCAAAACTTTCCGCAAAGAGGACTTCCTACAAATTCATATACGTCACTATCACAAGGAACTTGCCGAGCACGTCAGTCACTGTCCCAAAATGCAGGAGCTGGCCGTTAAGCGCACGCATCCCTCATCGATTGAGCAGGGCGACCAGACGCCAAAAAATCAAATACCAAACCAGCAATTCTTTGCCAAGCTGCACCAGCAGGACTTGCAGCAATCTCGCTCTTTCCGACGCAATCCTGCGGCTACTGAAACATCGCCAACGGGTCAGGACGCATCTTCACATCATTCGCCCATCAATGCAAGCATATCAATCAAAACGGAACCAACGACACCAAGATCTGTGCCGCAATCAGTTGCCGTCTCGCCAGAAGCTGGTGCCGTTGAAATTGCAACAGGTGCGCTTTTAAACCAGCCAATAGCCCCAACACCAATCAACTCGCCGACATATAATCGAGCTGCCAAACGTGCGCGTCCTTCATCTAGAAGACGCCCGTCCGGATCCCGTAAGAGCAGTCGTCAACGCTCACTGCGCCGTCCTGTAAATGAAAAAAGAATTCCAGCTGCTGTTGGTAACACGCGCAGCTTGCCAGCGGCAGCGGGAGTGGATGCCGAGCCGAGTCGACTATCGTCGTATAGCACGTCAATGCCGGAGGTACGCAACGAACCCAAAAAGCGACGCATTGCAGGTTCCGGAACACCCTCCGGCTCACCTGCTAACATGGATTTGGTGCCGAGGTCGTCATCAAACGATATGGTTGACATAAATGCAGCTTTGCCGCCACCGCCTACACCGTTGGCCAGCCAAACGCCGCAGTACATTAAGGAGAACGGCGAATTGATACGCATTGTTCGGATGCGGCAGGAGGAAATCATTAGTTGTATTTGCGTATATGGTGAAGAGGATGGCTTGATGATACAATGTGAACTATGCCTGTGCTGGCAGCATGGCGGCTGCCATGGCATTGTCAAGGAGTCGGACGTACCCGAAAAGTATGTCTGCTATATTTGCCGCAATCCGCAACGTGTGCGCGATTCGATGCGCTACAAACATGATCAGGACTGGCTATTTGAAGGCAAGCTGCCCGTGGCTGGTTATCACACGCCTAATCCTCAGGCTGCCAAAAAGTTCGAGCTGTTAAAGCATTCACACACCTTGACTGGCAATTTACTTGATGCCAAACGGTTTATGCACTCGCTCCAGGTCAAGATCAATATTGCGCGCAATCGTTTCCACCCGAAGCTGTATCTCTGGGCCAAGAAGTGGGACGCGGATAAGACAGATGCGTCTGTCACGCCTGTAAAGCGTCCGAAGTTTGAACCACCTGGTTTTCCGCATGCACCACAACCGGAGGCTGCTATCGATCCCGAAGAGTGCCAGTATCGTCTAATTGATCACATCAAAATACAACAATCCCTCTTGGCGAAAAGACTCGATGACATTGAAAGCGAAATGAATGACCTCGAAAACGAAGACAATTTGCCCGATCTGAAAGAATCTAACTTTTCGACATCTAAAGAAGCCCTGGCCATTTACATTAAAGAGCTGGAGACGATGAAACGTTTGGCAAAGCTTAACAACGTGGCCAACATGAAGCAGTCTCTAAAGGACCAAGAAACAGCGTCTCAAGCTTAA
Protein Sequence: MGRRCCVAECPSTSRLLEHHGVTYHSFPMDPVIRAIWIKNSRTSLDRQITKSVLVCSRHFRRLDFNTVRNGKYLLKPRVFPTVFPWGKMEPAEIEADQRALQQATVDGSGVSGAANSASSEDLIKATVDQIVAQIHAETAERNAAAAAAAEAAAKAEAEAQANAVKEGTGKIEASTSAAAAAAAAAVVSVESKADETVSDDAAAGTAEAANETLPDTSSTNSPVSVTPSKYGPPTNLTIGARLEALSVDGTWLTARIVEINNTEQTLLVRFERNSKLKSMPSSNGSYQEWMGVKSDRLRQRISLRVLPLFKLEEKCMARWTGPRKFPGTIKKILDNDTYEVLFDDGYTKNVRAVHMNKLPRQLPTASAEATTGSTHTETAAESVPVSVPVESGGVKRPSTGSTSSKKKSKITPQRKDWPLLDMSNLDLAALGLPDIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVHDWRLPEGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKVFLESQGKIYNPDVYDFSIHRRRAKDINAYVYTHDYSPQQPVKPKPMDVSLDSTATSQDLNSSKLSTATPIAAMSTRRTAADESQYMETPVASLVPPAELMSPSPQAQTLEPLPSATEAAEISSALSGEEPARVLVENGYAFIGGLKVQITDNLFVCPREGCGKTFRKEDFLQIHIRHYHKELAEHVSHCPKMQELAVKRTHPSSIEQGDQTPKNQIPNQQFFAKLHQQDLQQSRSFRRNPAATETSPTGQDASSHHSPINASISIKTEPTTPRSVPQSVAVSPEAGAVEIATGALLNQPIAPTPINSPTYNRAAKRARPSSRRRPSGSRKSSRQRSLRRPVNEKRIPAAVGNTRSLPAAAGVDAEPSRLSSYSTSMPEVRNEPKKRRIAGSGTPSGSPANMDLVPRSSSNDMVDINAALPPPPTPLASQTPQYIKENGELIRIVRMRQEEIISCICVYGEEDGLMIQCELCLCWQHGGCHGIVKESDVPEKYVCYICRNPQRVRDSMRYKHDQDWLFEGKLPVAGYHTPNPQAAKKFELLKHSHTLTGNLLDAKRFMHSLQVKINIARNRFHPKLYLWAKKWDADKTDASVTPVKRPKFEPPGFPHAPQPEAAIDPEECQYRLIDHIKIQQSLLAKRLDDIESEMNDLENEDNLPDLKESNFSTSKEALAIYIKELETMKRLAKLNNVANMKQSLKDQETASQA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01323413;
90% Identity: iTF_01322686;
80% Identity: iTF_01322686;