Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 9.2e-14 3.2e-10 39.7 0.0 1 50 9 54 9 65 0.92

2 2 9e-06 0.031 14.1 0.0 26 75 127 185 111 187 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	9.2e-14	3.2e-10	39.7	0.0	1	50	9	54	9	65	0.92
2	2	9e-06	0.031	14.1	0.0	26	75	127	185	111	187	0.86

Coding Sequence: ATGCAAATGAATCCCAGCGTGACCATAGAACGCAAACGCGTTGACTGCAACGTGCTTCCCAAGGATGATGTGCAACGAAAGTCTGGAGCTGGGTCAGGCAAAGTTGATGTATTTTATTACAgTCCCACAGGAAAGAAAATTGATAGCAAACCGCAAATGCTGCAGAATCATTTGCCATCGCCATCCACATCACTATACCGCTGCAACTCATCCGGGGCCCCTGGAAGTTCGGTAAATGCACTTAAACGAAAATTCAGAACCCAGGCCAATACTGTCAACCAAAACAATCCCAACAATATGGTGGCCAACACTGCAACCGCAGGACCACCATCGGCAACAACAGTCCCGGCTAACCTACGCCAGCAGCAACTCGAATTCAGTCGCGCCTTACGCACAGATGTTTCCCTGGTACCACCAATACGTCAGACCGCCTCAATTTTCAAACAGCCAGTCACTGTCATCAGAAATCATGAGCCCAGCAAGGTGAAACACGATGCCAAACACGGTGGCCAAGAGAAACCCAAGCAGGTATTCTGGGAGAAGCGTTTAGAACGTCTGCGAGCCTGCCATGATTCGGGTGAAGAACTCGATGACATTTCACTGCCCAAGACCATACGTAGCGTGGGTCCCAATGTCAACGAACAGACTGTACTCCAATCCGTGGCAACGGCTCTCCATGTCCTCAACGCTGGCGTACTCGGCCAGACCTCCACAAAGGCTGATCTAACAAAAAATGCCATGGCATTTATGAATCCCGAGCAACCGCTTATGCATTCAGTAACCATATCCGAGGAAGACATACGTAAACAAGAGGATCGTGTTAGTCTAGCGCGACGGAAACTTCAAGATGCTCTAAAAATCTAA
Protein Sequence: MQMNPSVTIERKRVDCNVLPKDDVQRKSGAGSGKVDVFYYSPTGKKIDSKPQMLQNHLPSPSTSLYRCNSSGAPGSSVNALKRKFRTQANTVNQNNPNNMVANTATAGPPSATTVPANLRQQQLEFSRALRTDVSLVPPIRQTASIFKQPVTVIRNHEPSKVKHDAKHGGQEKPKQVFWEKRLERLRACHDSGEELDDISLPKTIRSVGPNVNEQTVLQSVATALHVLNAGVLGQTSTKADLTKNAMAFMNPEQPLMHSVTISEEDIRKQEDRVSLARRKLQDALKI

Sequence clustering based on sequence similarity using MMseqs2