Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00022 1.9 9.6 0.1 17 50 42 75 36 79 0.84

2 6 0.00026 2.3 9.3 0.1 23 45 76 98 72 102 0.89

3 6 0.0027 24 6.1 0.3 21 44 102 125 98 133 0.85

4 6 0.031 2.7e+02 2.7 0.1 21 44 130 153 127 161 0.86

5 6 0.00055 4.7 8.3 0.0 23 45 160 182 156 189 0.84

6 6 0.7 6.1e+03 -1.6 0.0 22 34 213 227 209 236 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00022	1.9	9.6	0.1	17	50	42	75	36	79	0.84
2	6	0.00026	2.3	9.3	0.1	23	45	76	98	72	102	0.89
3	6	0.0027	24	6.1	0.3	21	44	102	125	98	133	0.85
4	6	0.031	2.7e+02	2.7	0.1	21	44	130	153	127	161	0.86
5	6	0.00055	4.7	8.3	0.0	23	45	160	182	156	189	0.84
6	6	0.7	6.1e+03	-1.6	0.0	22	34	213	227	209	236	0.73

Coding Sequence: ATGGCCTCGAGAGAGGAGTACGATGAAACTATGCCATTGAACAGTGTGGTGGCCATGTACACCTGCAAAAGATGTAATAAGATATTCCCCTGCAAACGTGATCAACTTTTGCACAAAAAAGAAGTCCACTCGCAGACAAAGTCCTCTTATGAATGTAAAATATGTTCGAAATATTTCTGTAATAGTGGCAATCTGGAAAGACATATAAAAGTCCATAATGATGTACGACCCTTTGTGTGTCGCATCTGTGGCAAGGCTTTTGCCCAATCGGTTAATTTAAATCGACACTATTCGGTACACAATGGCGAACGACCGTATCAGTGTACCTTCTGTACCAAATCGTTTACCCAACAGTCCAACATGCAGCGCCATCAACTGACGCACACAGGAGAGAAACCATTCCGTTGTAAACGTTGTGGCCGCTATTTCTCCCAGCGTGTTAACCTTAAAAAACATATAATGGGCCATTTAAATACTAAGCCCTACACGTGTAAAATCTGTCAGAAGTCATTCATACAGCTGGGCAATTTTAAGAAACACTTGCAATCCCATGCGAAGGATGGCATAGAAATGGATATGAAGGCAATTGTTGCAGAGGCTCAGGCTATTGCTAAACAAAGTCTAGAAATGGCCGATGAACAACCGGTTGGCTTTGAATGTGCTGTTTGTCGTTCGGTATTCAATAATTTCACCGACTTTGAAATGCACGAAAGTGAATGCAACGATAATGCCCAATCCTTAGAGCAGAAATACAATCCCGAACAGCAACTACACGAAGTTGTAGTCGAAGATGTTGAAGATCATGCCGAAGAGCATGTTATAACGCATGAGGGCAATCCAGTAACCGGTGGTCATTTTGGCAGTTATGCACCCTTAAAGTTTAGTGTCTCACAATTGGATACCCatgaaataattattgaaacCAGTCGATAA
Protein Sequence: MASREEYDETMPLNSVVAMYTCKRCNKIFPCKRDQLLHKKEVHSQTKSSYECKICSKYFCNSGNLERHIKVHNDVRPFVCRICGKAFAQSVNLNRHYSVHNGERPYQCTFCTKSFTQQSNMQRHQLTHTGEKPFRCKRCGRYFSQRVNLKKHIMGHLNTKPYTCKICQKSFIQLGNFKKHLQSHAKDGIEMDMKAIVAEAQAIAKQSLEMADEQPVGFECAVCRSVFNNFTDFEMHESECNDNAQSLEQKYNPEQQLHEVVVEDVEDHAEEHVITHEGNPVTGGHFGSYAPLKFSVSQLDTHEIIIETSR

Sequence clustering based on sequence similarity using MMseqs2