Sper004298.1
Basic Information
- Insect
- Sarcophaga peregrina
- Gene Symbol
- -
- Assembly
- GCA_014635995.1
- Location
- CM025789.1:101634957-101635976[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 2.7e-08 2.3e-05 25.0 0.3 21 103 9 90 3 106 0.87 2 2 6.5 5.4e+03 -2.1 0.0 97 110 277 290 267 328 0.66
Sequence Information
- Coding Sequence
- ATGGCTCGTAATAAATATTCAgtgcatttaaaagaaaaaataattgaagattttaataaagGAGAATCTGtaacaaaaattgcaaagaaatttaatattcatcatAGCGTAATTTCCCGAATTATAAGCCGCTTTAAATCAACAGGTTCACTGGTTACCATACATAAGGGTGGAAAACCACGGAAAACCACTAAACGGGAAGACCAGGCcataattcgaattttaaaaaaggatCCCTTTACATCTGCAAGGTCCATTGCAAACCAACTGGCATTAAATATTACTCCTAGAACCATTCAAAGAAGAACGGTAGAAGGTGGCTTAAAATCGTATAGGACTGtaaaaaaaccatttatttccacaaaaaatagACAGGCTAGAATTAATTTTGCGAAGGAACATTTAAACTGGAGTGTAACAGAATGGAAGACAGTACTGTTCTCCGATGAATCCAAGTTTAACTTGAAGGGTTCTGATGGATATCAGTTAGTACGGAGACCAGCAGGGCAACGACTTAATCCACTGTATACTAAAGGAACTGTAAAACACGGAGGAGGTAATATAATGGTCTGGGGATGTTTCTCTGGTCAAGGTATTGGAcccattcacaaaataaatgggATAATGGACCGTTTCATGTATAAAGACATACTGGAGAATGTAATGCAGCCATATGCGGTGGAGGAAATGCCACTTAATTGGAGGTTTCAGCAGGACAACGACCCCAAACACACTGCAAAATGTGTGAAAGAGTGGTTTGTTGCAAATGAAATCAATGTCTTGAAGTGGCCAGCGCAATCGCCAGATCTCAACCCGATAGAAAACCTATGGGAAATTGTAGATCGGAAAATATTACGCGATAATTGCAAGAATTTGGAAGACCTTTTCCGCCAAGTGGAAATAGCCTGGAATAGTATTCCTGGGGAGGTTATATCGAATCTAATTGAGTCCATGTCTCGTAGATGTAAAGaagtcttaaaaaataaaggctatgccacaaaatattggaaatatttttag
- Protein Sequence
- MARNKYSVHLKEKIIEDFNKGESVTKIAKKFNIHHSVISRIISRFKSTGSLVTIHKGGKPRKTTKREDQAIIRILKKDPFTSARSIANQLALNITPRTIQRRTVEGGLKSYRTVKKPFISTKNRQARINFAKEHLNWSVTEWKTVLFSDESKFNLKGSDGYQLVRRPAGQRLNPLYTKGTVKHGGGNIMVWGCFSGQGIGPIHKINGIMDRFMYKDILENVMQPYAVEEMPLNWRFQQDNDPKHTAKCVKEWFVANEINVLKWPAQSPDLNPIENLWEIVDRKILRDNCKNLEDLFRQVEIAWNSIPGEVISNLIESMSRRCKEVLKNKGYATKYWKYF*
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00258824;
- 90% Identity
- iTF_01314631; iTF_01314632; iTF_00258825; iTF_00258826; iTF_00258827; iTF_00258828; iTF_00258829; iTF_00258830; iTF_00258831; iTF_00258832; iTF_00258833; iTF_00258835; iTF_01260951; iTF_01260955; iTF_01260956;
- 80% Identity
- -