Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.079 63 3.9 1.3 2 48 96 146 95 149 0.64

2 6 0.06 48 4.3 0.2 17 48 173 204 164 207 0.87

3 6 0.0017 1.4 9.2 0.1 19 45 204 230 201 235 0.86

4 6 0.0013 1 9.6 0.5 20 48 234 262 230 263 0.86

5 6 7.4e-06 0.0058 16.8 0.1 20 51 263 294 260 295 0.87

6 6 2.3 1.8e+03 -0.8 0.2 26 48 298 320 297 323 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.079	63	3.9	1.3	2	48	96	146	95	149	0.64
2	6	0.06	48	4.3	0.2	17	48	173	204	164	207	0.87
3	6	0.0017	1.4	9.2	0.1	19	45	204	230	201	235	0.86
4	6	0.0013	1	9.6	0.5	20	48	234	262	230	263	0.86
5	6	7.4e-06	0.0058	16.8	0.1	20	51	263	294	260	295	0.87
6	6	2.3	1.8e+03	-0.8	0.2	26	48	298	320	297	323	0.81

Coding Sequence: ATGAGCTCTTCTAAAGATCTTACACATGCTGCTTCGAGCAGACATGGAGGCGAGAAGAAACTTTGTCTTGGTCTCTTCTGTCAAGAAGGTGCTCCATTCACGTCAGAGCCTAGGCTGAGACCACTTAAATCATCATCAGGATGCGCAGAAGGAGCTACAAAATCGGCTAGCAGCTCTAAAGTAACCAACTCATCAAAGACTTGCTCATCTCCTAGCGTGAAGCGTTACAGATGTTCTGAATGTAACTACAGCGTGAACAGCAGGAGCAAAATAAAATATCACATAAAAGCTAAGCGCACAGTCCGCAAACCATGTCCTGCTCGCAGCGATCATCGCTTAAAAACTAATCAAACCCGCGAAAAAATATTCACCTGCCCGCACTGTGTTTATGCTACTCCCAAGTCTTATTTATTAAAGGAACACGTAACGGCGAATCATACAAGTGGCATACTTATCAATTGTCCTCATTGTGAGTATAACACTGTTATTCATGATCATTTAAAGAATCACATAATGTCAAGGCACACCGGCGAGAAAAGTCACAAGTGCCCTCAGTGTGAGTACAGCAGTGTCCAGCCCGGCGATATAAAGAAACACTTAATAGCCAAGCACTCGAGTGAGAAACCTTTCGCTTGCCCTCACTGTGAGTACAGCACTGTTCAGTCTGTGAGTCTCAAAAACCACATAATGTCTTGGCATTCGAATGAAAAGCCACACAGCTGTCCTCACTGTAAGTACAGTTCCGTTCACTCTCGCACTCTGAAGAAACACATATTGGCAAAGCATTCGAGTGACAAACCATTCACTTGCCCACACTGTAAGTATAGTACTATCCAGTCTGGCGATCTAAAGAGGCACATAATAGCGAAGCATACAACTAAATTTCTTTTCACTTGTTCTCACTGTAACTACAATACTGTTCACTCTGCAGCTCTAGAGAGACATATTCTGAAGAAGCATAAAACTGACAATCTTCGAGCAGATACTTTGCACAGTTGA
Protein Sequence: MSSSKDLTHAASSRHGGEKKLCLGLFCQEGAPFTSEPRLRPLKSSSGCAEGATKSASSSKVTNSSKTCSSPSVKRYRCSECNYSVNSRSKIKYHIKAKRTVRKPCPARSDHRLKTNQTREKIFTCPHCVYATPKSYLLKEHVTANHTSGILINCPHCEYNTVIHDHLKNHIMSRHTGEKSHKCPQCEYSSVQPGDIKKHLIAKHSSEKPFACPHCEYSTVQSVSLKNHIMSWHSNEKPHSCPHCKYSSVHSRTLKKHILAKHSSDKPFTCPHCKYSTIQSGDLKRHIIAKHTTKFLFTCSHCNYNTVHSAALERHILKKHKTDNLRADTLHS

Sequence clustering based on sequence similarity using MMseqs2