Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 2.7 2.1e+03 -1.0 0.0 33 46 46 59 35 61 0.75

2 6 0.0012 0.92 9.8 3.5 16 52 94 131 90 133 0.84

3 6 1.2e-05 0.0094 16.1 0.3 19 48 155 184 150 187 0.89

4 6 0.00062 0.49 10.6 0.3 21 49 186 214 182 216 0.86

5 6 0.00017 0.14 12.4 0.2 17 49 211 243 210 247 0.83

6 6 0.028 22 5.3 0.3 22 48 245 271 243 275 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	2.7	2.1e+03	-1.0	0.0	33	46	46	59	35	61	0.75
2	6	0.0012	0.92	9.8	3.5	16	52	94	131	90	133	0.84
3	6	1.2e-05	0.0094	16.1	0.3	19	48	155	184	150	187	0.89
4	6	0.00062	0.49	10.6	0.3	21	49	186	214	182	216	0.86
5	6	0.00017	0.14	12.4	0.2	17	49	211	243	210	247	0.83
6	6	0.028	22	5.3	0.3	22	48	245	271	243	275	0.85

Coding Sequence: ATGAGTGCTGCTGGATATATTGATATTGTGCTGAGCTCCATTAAAAATGATGAGGATTCTGCGGACGAGGAAAGCCTCTGTTCGCCTAGAGAGTTCAACCTCAATAAACCTGAGTCACCATCCATTGGAGTAAAAACATCAAGGGGCTGTAGAAACTCAAGGCGGGAAGTGAATCTATCAGTGGAATGTTTAACTGTAACTGCTAGTGTACAGAACCATTTTAACTGTTGTGAATGCAGTTACAGTACAAATTATAGATACCTCTTAAAGCAGCACATACAGTCTAAACATTCAAGTGACAAACCTCACTCCTGCCCCTACTGTGAATACTGTGCTGTTCGGGCAGCCCGCCTAAGGCTTCACATACTGGCTAAACATTCAAGTGCTAAACCCCATTCCTGCTCCTACTGTGAATACCGTACTATTTGGAAGGGCCGTCTAAAGTTTCACATACTGGCTAAGCATTCAAGTGACAAACCTCACTCCTGCCCTTACTGTGAATACAGTACTGTTCAGGCTCGCAATCTAAAGCATCACATACAGGGCAAACATTCAAATGATAAACCTCACTCCTGCCCCCAGTGTGAATACAGTAGTGTTAGGGCTAGCGATTTAAAACGTCACATACAGAGTAAACATTTAAGTAATAAACCTCACTCCTGTCCCTACTGTGAATATAGCACTGTTAGGGCTGGTGATTTAAATCGCCACTTACAGGGTAAACATTTAAGGGATAAACCTCACTCCTGCCCCTACTGTGAATACAGTTCTGCTCGAGGAGACAATTTGAAGTGTCACATACAGGCAAAGCATACTAGAGACAAATCTCCCATATAG
Protein Sequence: MSAAGYIDIVLSSIKNDEDSADEESLCSPREFNLNKPESPSIGVKTSRGCRNSRREVNLSVECLTVTASVQNHFNCCECSYSTNYRYLLKQHIQSKHSSDKPHSCPYCEYCAVRAARLRLHILAKHSSAKPHSCSYCEYRTIWKGRLKFHILAKHSSDKPHSCPYCEYSTVQARNLKHHIQGKHSNDKPHSCPQCEYSSVRASDLKRHIQSKHLSNKPHSCPYCEYSTVRAGDLNRHLQGKHLRDKPHSCPYCEYSSARGDNLKCHIQAKHTRDKSPI

Sequence clustering based on sequence similarity using MMseqs2