Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.31 5.5e+03 -1.4 0.6 56 66 7 17 3 21 0.64

2 3 1.2 2.1e+04 -3.3 0.2 7 20 74 87 71 88 0.71

3 3 2.6e-17 4.6e-13 50.1 8.9 2 69 92 159 91 160 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.31	5.5e+03	-1.4	0.6	56	66	7	17	3	21	0.64
2	3	1.2	2.1e+04	-3.3	0.2	7	20	74	87	71	88	0.71
3	3	2.6e-17	4.6e-13	50.1	8.9	2	69	92	159	91	160	0.96

Coding Sequence: ATGACGGGAAAGTGCAAAAAAGTTCGGTGCCTTGTCTGTAATGAGATTCTCACATACGATAACGACGACACCTCCGTGCTGGTGGACCATCTAAACCTTGAACACTCGGGTCTGGACGTGTTCAGATTCCTCGCACATTGTCAAACGTCCAGTCCGAGAGCGAACAAGAAAACTCAAAGCAGGGAAAATTGTTCCATGGAAGCAGGCGATGTGCCCAGCGAGTGcgagatgaagaagaaaacatATAAAACGACAGTTGAAACTTGGACACCCGGGCCCAGATCGGTGTGTTGTCCGAAATGTGGCAAAGAAGGACAGCCAATAGTAAAGAAGCAGAAgaataaaatggcaaaatcTCCGCTGGGTGCACTCTGCATGCTGGGatGTTGGCCCTTTTGCTTCCTGCCTTTCCTCTTCAGAAAGGATcagtttttagatttatactGTTGCAACTGTAAATGCTACTTCGGAACTTTTGACAAAAGAAAGCAATGCATGACACGCTCCCCGAATGCAGCAAGTGAACCAGCCTTGCACGGTCGCACTGACACGACAATAGGTACACAACCTCCGTCCTATGAGAACAAGGAACCGGCAGCACGCGATGCACTCATCTGCAAGCCTCCTCCTGTACCCAGGTACGGGAAAATGCATTCACATGTGTAA
Protein Sequence: MTGKCKKVRCLVCNEILTYDNDDTSVLVDHLNLEHSGLDVFRFLAHCQTSSPRANKKTQSRENCSMEAGDVPSECEMKKKTYKTTVETWTPGPRSVCCPKCGKEGQPIVKKQKNKMAKSPLGALCMLGCWPFCFLPFLFRKDQFLDLYCCNCKCYFGTFDKRKQCMTRSPNAASEPALHGRTDTTIGTQPPSYENKEPAARDALICKPPPVPRYGKMHSHV

Sequence clustering based on sequence similarity using MMseqs2