Rarc017700.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Ricinus arcuatus
Gene Symbol
MBD-R2
Assembly
GCA_027475445.1
Location
JAOXJT010006468.1:143746-148973[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 8.4e-10 5.9e-06 27.0 0.1 7 70 349 409 344 415 0.93
2 3 2.3e-14 1.6e-10 41.6 0.2 7 70 507 568 505 574 0.93
3 3 2.3e-17 1.6e-13 51.2 0.0 7 70 655 716 652 718 0.96

Sequence Information

Coding Sequence
ATGATGCGAAGTAAAACTTTTTGTCAGAGAATTATTGAAAATATAGGAGTAAATGACTGTCACAATTTAAAAACTTCAAAGGATACAAAAGCTCAGCTTCATAATAGTAATGATGCATTAGCTACAGGTCACAATGTCACAGTGTCAAGTACAATGATTAAAATTACATACAATAAAGGAGCAAAAGATCAACCTGGACAATCTGTCATTAAAAATGAATATGAAAATAATGAAGATTTTATAATTTGTGAACCACCTCAGTCCAATTGTTTTAATACCAAGCATTCTTCAGTTATTGACAATCGTTATAAAACTTCTGAGATTAATTTTGTTCCTGATAATATGGAAGCAACTTTAAACAATGGATCATCTTTAAAAAAAAAAAAAGCATCTATTGATGAAAAATACAAAGGAATTATAAATCAAGAGAAACAACATATCTTAGCAAATGATAAGTCTTTTACTAAAAATTGTACTAATGTAAAAAACAGTAATATGAACACTCAGTTTTCACATAATCTTAATCAGTTCAAGGAGTTAAAAGTTAAATTGCCTAAACTTAGGTTATTAGCATCTCAATCATCTACCAATTCAGCAAAATCTGTTTTTCAGTTCAATGAAGAGAATAAAAATCTTTGTTGTAGTGGTACTGATGAATCAGGGAATAAAAAGTCTATAAAATCTGAAGATGTAAAAATCTCACATGAAAGAAGAGATTTTAGTTTTAAAGATAACATAGGCAATTTTCAAATCAAGTATGATCCTTCAAGTTCTGAAGTGTCTGAACAATTTGTGAAAGAATCGAAGGTACCAAAGAATAAAAATGAATGTTTTAAAAATAAAAGATTCACATGTGTAGATAGTTGTCAAAATAAAAAACTAAAAATTGATCCTTCCATAATAAATAAATCAACAAAGGATAAATTGAATGAATCAAAAGTTAATGATAAAGAGAAAAAAACAAATATAAATAACATGAAAAATAAAAGTGTTATTAATTCTGATCATATAACAGTGGAATTACATAAAAAGCAGTTATTGATTGATGATCCAACTCTTCCAACTGGTTGGCAGAGAATAATAAAAGGGAAACATTGTGGCACAGAATTCAAACCTGTTGTATGCATTGCTAGTCCTGAAGGTAGAAAATTCTACTTTAAAGCAAAGCTGAAGGATTACTTAGAAAGGACCAATTCTCCATTTACCATTGATGACTTTCATTTTGGTTTATATAAAAAACAACCAAAGGAGAAATATTCTGTTAATGAAAAGAAGATTGAGAAAAAAAAAAATTCTAACAAAGCAACAAAAGAAAAAAAATGTCAGGCAATTTCTCATGGTAAAAGAGTAAAGCAAGTAACTTCTAATAATGTAGAAGTTACAAAGCAAGGAAGTGGACAAATTAATTCTTTTTCTGCATCAGTTAATAGCTTAGAAGAAAATGCTTCATTGAGTTCAGGTGAAAGAACTATCAAAAGAGATGAACTGTGCAATTTTAAAGATAAGAATTTTTTAGTAGTCGACCCAGATTTGCCCACAGGCTGGACTCGAAAAATCCGTATTAAAAAAGACGGGAAAAGTCACGATAAATTTCAAGTTTGGATTGTAAGTCCCGATGGGAAAAAGTTTCGACGAAAATATTTATTGCACAAGTACTTAATTAGAAATCGATCTGCATTAAATATCGATCAATTTTATTTCGGTCTCTACCCAAAAAAAGGATTAAATTTGGGTCTAAACGATGAATCAGCAGACAAGGTTAAAAATAGACAAAAATTGAAAAATTTAATCGTACCTATTAAGAAATACGTAAGGTTAAATAAAACTAATGCTAAGAAATCGGAAAACGAAGTTAAACAAAAAAAGAATCCTTTTCGGGATTTACTTGGAAAAAGACAAATGAATTTAGTTTTGAATAAAGTAGATAATGGTGAAAACATTTACGGTGGTCAGCCAATGTTTGACGATCCTAATTTGCCTACCGGCTGGCGTCGTCATATTAAGGTTCGATCTACAGGTGAAAGTGCCGGAAGAATGGAGGTTATTATAATCAGTCCCGATGGCAAAAGGCATAGATCAAGAGGAAATTTGGAACATTATATTAGACAAAAAGGCTTAAATTACAATATTGATGATTTCGATTTTTCGATATTTGGAAAAAATTCTAGAACTCATAATTCTACTTTTATGAACACAACGGCAAATAAATACAATATCAAGAAAAGGGAATCTACATTACTTTCAAATACAGTGGCTCGCGATTCGAAAGATTTTGATTCTTCCATAAAGTTAAATATAAGTCGAGAAGCTTTACTCATAAATTATGTTAGCGGGTTAATGGTCAACTGTGGATTGAGAGATGTAAGAAGCGAACGCCGTCAACGAATTCCTCGAGACGAACATGAAAGAATATTAAAAAAGCTCTTGGATTCAGAAAAAGAAGCAGTGAATGATGAAAACGATATATCAACTTCTTGGATTCAAAAATTAATACACTGCCGGAGTGACTTTGGAACATTGGACGTTGATGCTGCTATGACTGTAGCTTCTTTAACAAAAGAATTTCTGCGAAAATTAACTCGAAAAGCTTTGGAAATATCCAAAACTGAAACCACTTTGGAATACAGTGATGTGGCAGAACTTGTAGATCAATCCAAGTGTTTGTCTCCATTAAAAACTTTAATTCCTAAAAAGATTACTTTTAGAAAATTCATAACACTGAATATGCCAAAAAATTATTTGTCTGTTTAA
Protein Sequence
MMRSKTFCQRIIENIGVNDCHNLKTSKDTKAQLHNSNDALATGHNVTVSSTMIKITYNKGAKDQPGQSVIKNEYENNEDFIICEPPQSNCFNTKHSSVIDNRYKTSEINFVPDNMEATLNNGSSLKKKKASIDEKYKGIINQEKQHILANDKSFTKNCTNVKNSNMNTQFSHNLNQFKELKVKLPKLRLLASQSSTNSAKSVFQFNEENKNLCCSGTDESGNKKSIKSEDVKISHERRDFSFKDNIGNFQIKYDPSSSEVSEQFVKESKVPKNKNECFKNKRFTCVDSCQNKKLKIDPSIINKSTKDKLNESKVNDKEKKTNINNMKNKSVINSDHITVELHKKQLLIDDPTLPTGWQRIIKGKHCGTEFKPVVCIASPEGRKFYFKAKLKDYLERTNSPFTIDDFHFGLYKKQPKEKYSVNEKKIEKKKNSNKATKEKKCQAISHGKRVKQVTSNNVEVTKQGSGQINSFSASVNSLEENASLSSGERTIKRDELCNFKDKNFLVVDPDLPTGWTRKIRIKKDGKSHDKFQVWIVSPDGKKFRRKYLLHKYLIRNRSALNIDQFYFGLYPKKGLNLGLNDESADKVKNRQKLKNLIVPIKKYVRLNKTNAKKSENEVKQKKNPFRDLLGKRQMNLVLNKVDNGENIYGGQPMFDDPNLPTGWRRHIKVRSTGESAGRMEVIIISPDGKRHRSRGNLEHYIRQKGLNYNIDDFDFSIFGKNSRTHNSTFMNTTANKYNIKKRESTLLSNTVARDSKDFDSSIKLNISREALLINYVSGLMVNCGLRDVRSERRQRIPRDEHERILKKLLDSEKEAVNDENDISTSWIQKLIHCRSDFGTLDVDAAMTVASLTKEFLRKLTRKALEISKTETTLEYSDVAELVDQSKCLSPLKTLIPKKITFRKFITLNMPKNYLSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-