Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.58 1.5e+03 -0.2 0.1 7 65 6 13 2 17 0.58

2 4 9 2.3e+04 -5.1 4.6 43 51 62 70 42 74 0.55

3 4 6.5e-13 1.6e-09 38.1 3.8 2 69 92 155 91 156 0.91

4 4 0.35 8.9e+02 0.5 0.1 4 13 160 169 157 179 0.78

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.58	1.5e+03	-0.2	0.1	7	65	6	13	2	17	0.58
2	4	9	2.3e+04	-5.1	4.6	43	51	62	70	42	74	0.55
3	4	6.5e-13	1.6e-09	38.1	3.8	2	69	92	155	91	156	0.91
4	4	0.35	8.9e+02	0.5	0.1	4	13	160	169	157	179	0.78

Coding Sequence: ATGGAATCAGCCCTGGTGTGCCAGATATGCGGTCAGAAGTTGTCGTTTAACCCGGGATGTCCGTGTTCGTTGGGCGAGCACATGCTGAGGAAACATCCCCATCTGGAAATGGGGCATTTCTCTAATCAGGATATATGTAATTGTTGTAGCGTTTCATCGAAAAATCGTCCACTTTGTTCTCGGACACAATTACCTTGTCTTTGTTCATCATTCGAAAAGCCACGTAAACCGAAACCCACCGTTTTCAAAACCACAGTAGAAAGTTGGAAACCAGGGCCTCTTAGAGTGACCTGTCCACGATGTCAGCACTTGGATCGACCGTGTATTCGCCACCAGAGAAACAGAatatcCCGATCAGCTTTGGGTGCCTTGTGCTTGCTGTTGTGCTGGCCGGTTTGCTTCATGTCCGAGAGCAGCAGGATCCACTTGTTCTGCCGCAGGTGTCACGCTTTCATGGGGGAGTACGATCGGAAGACCGGACGCATGAAGTGTCCACCCTGTCCGGCCAGCAGCCGGTACGACCTCAACACCATCCCGTCCGTCTGCTAG
Protein Sequence: MESALVCQICGQKLSFNPGCPCSLGEHMLRKHPHLEMGHFSNQDICNCCSVSSKNRPLCSRTQLPCLCSSFEKPRKPKPTVFKTTVESWKPGPLRVTCPRCQHLDRPCIRHQRNRISRSALGALCLLLCWPVCFMSESSRIHLFCRRCHAFMGEYDRKTGRMKCPPCPASSRYDLNTIPSVC

Sequence clustering based on sequence similarity using MMseqs2