Rfer020319.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Rhynchophorus ferrugineus
Gene Symbol
MBD-R2
Assembly
GCA_014462685.1
Location
JAACXV010000341.1:24401-32267[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 7.3e-19 3.3e-15 55.8 0.0 8 70 418 479 412 485 0.94

Sequence Information

Coding Sequence
ATGGGGCGTAAGTGTACTGTACAAAATTGTAAATCTGATTCAACCAGACCAGAGCATGTTGGTGTAACGTTCCATAAAGTTCCCCATCATTCTGATGTTCGCCCCAAGTGGATATCTTTGTGTCGAATATCAGAAGATAAATCAAACGCTAAAGTACTTTACGTATGCTCCCGGCACTTCCTAAGAGCCGATTTTTGTAGTTTTAAAGGGAAGAAATACATGTTACGACAAGGAGTGCTACCTAGTGTATTTCCTTGGGATAAGTCTAAATTGGACGCTATAAAAGCCGAAGTAACAACAAAGAAAGAAGTGGAGATaccaaaaaagaaagaaaaaaagaataaagaaaaGTCTAAAGCGGAAAATGTTTCTATTTCAAAAAAAGATTATGATACCACGTCAGAATCTGACGAAAGTAAAATTGAGTCAGATAATTTACCTAAAACAGATAATAGTATTCAGGCAGATGAGAAAGATAACCCTAATGCTGATATTAAGGAGGAAACAGATGCATTTGACCAACATCAAAGATCTCAGTCAACATCTGCTCCCACTAGtccaatgatttttttaattaactctaaAATAGAGGTCTTAGATAATAATGTCTGGTATACAGCAAAAATAAATGAGGTTGACTATGAAGAAAGCGAAATTCTAATCCATTTCGAgcattattcaaataaatatgatGAATGGATATCGATGTCCAGTCCAAGACTACGACCTATTCAGCCTAAACTAACAGAGAAGTATGAATTAGGTGAAAAATGTATGGCAATTTCGAATGATACAAAAAAGTTTCCAGCTACTATTACTAACATAATAGATACTGaaacttATGAGGTGCGATTTCAAGATGGTTTAAACCAGACAATTAAAGTTGATAAGATATCGAAAATTAGCAAAACTAAACCAGCACAAGCTTCACCCTTGTTTGAGCCTATCAAAAGCTCTAAACAGGAACGTCGTGATAAGAAGAGAAAGTTGAATGTTGCAGAACTTTTCGGTAAGCGCTGCAGATCTTCCCATACAGAGGACAAAAAGATGAAGACACCCTCAACATCACAGCCAACAGAAGAGTCAACAAGTTCCGCTCCAGATGCTCCTGACCAGAAAGCTATTCCAATTGCAGACTCTTCAATGAATTTGTCAGATCAGTGGCTTCCGacgTTTGAAAATGGGAAACCAGTTGGTAAGGATTCAAAGATAGAAAGTATAGATGGAGTTCGGAAATCTGTAATTGTGCCTGATCCAAGGATACCGTCCAATTGGGAGAGGCATTTAGCTCAACGTAGTCATGGCACTTCTGCTGGCAAGTGGGATACTATATTTATAAGCCCCGACAATAAGAAGTTTCGAAATAAATCCGAAATTAAAGCATATTTGGAGCAAAATCCAAATGTAGACGTAAGCCTCGACGTCTTTGACTTCAGCATTTATCGGAACGGTCATAAAAGGAAATCGATTAAACATAAATCGAAAACAGATAATCAAGCCGAACCTAATGAGGAACCTGTAAAGGAGGAACCAGTTAATAATGAAGAAGTTTCAACGCCTACTGtgaatctaaaaattattttcgaggATGATAGCTACAAATGTCCAATTGAAGGTTGTGGAAAGAACTTCCGTAGAGAGAATTTGGCATTGATGCACGTGAAGCATTATCATTCTGAATACACCAAGTATTTAGACTCAACGCCAAATGTAGCTGATCTGGCGTACGCTCGTACAGTTGGCGAGAACCTTGATAAGTCACCGGGCATTGTCAAGCCTGGTACACCAAAAGCTGCTATTGACAAGACACCAGTTTCAGCCAAAGTAAGCAAAGCCGCACATATGCCAGCAGCAGAACCAAAAACCCCAGGTAACAATTCACCCAATCCAGAGGCGAAAACACGAGATGCCGAAATAATAAAGCTCCTAAATCAGAAAGTCGCCGAACCTGATAAAGATATCCAACCCTTGCCTTCTGGTTTGCCATCCAGTATGTATCCAGATATAAAGTTAAAAGATTTGTTGAGTAAAACAGAAGAGATTCCTCACAAGGATGAACTAAACATCAAAACGTTGTGCGCCTCTAGGCCCACTCATGGTATAAAAACACTTCTACCTGTACGGTCTAGTCAAGTATCTATGGAGAACCATGAAGAAAAGATCATCAAACGGAAACGTCCACCTTCTGATAGTCTGGACACTCATAAAGGTAAACAACCTCGACACTCAACCGTCAGTCCGCCAAAGTCCGACCACAACCAACCCACGCAACAACCTCCACCACCACAAAAACATCCGGTCGCGTCTAACCAGTCTTCGAACTCGCAATCTCCGCGCTCCGACATATCCGCCATACCTTCGGCTTTCGATCTAGCGCCACCTGTGGGGTTACGTACTTCTCAGCCACCGCCGGCTGTAACCCCTTTCGATGGCGTGATCATCGAAGGTggcaaaattatcaaattagaGCGCATGAAGCAAGAAGAGATAATCAACTGCACCTGCGGCTATACCGAGGAAGATGGGCTGATGATCCAGTGCGAGTTGTGCTTGTGTTGGCAACACGCACACTGCAACAACATACAGAAGGAGAGTGAAGTGCCCGAGAAGTATATCTGCTACATATGTCAGCATCCAGTGAAAGAAAGGAGATCGATGAAATATTTGCATGATCAAGATTGGTTAAAACAAggtACTTTGCCAGTTGCATCTTATCATACAAAAGATGACGATGAATTACGGAAAAGATTCGAAAAGCTGAAGAAATGCCATGACCTTACTGGTGGCGTGCATGAACTTAGAGATTATATGCATACTCTAgcctacaaattaaaaatagccGAggcTAAAAACCACCCGAAACTGTATTTATGGTCAAAACCGTGGGAAAAACCAAAATTACCGGAAAAAGCCAACGTAAAAGACGAGGAATCGGCGGACAGCAAGGTCAAGATCGAAAATATGGATCATCAGTATCTCAAGAACGAAATGGCCGTCGAGAAGCAAGAAAACCAAAACGATTCTATGCTGATGATGATACTGAAAGACAACAAGGAAGACGTCCCGATGCTGAACGATCACAATAGCTTGGCTCCGATCATACCCAAGCCCGAGGCGGCGATCGATTCGGATGATTGCAGGCTCAACTTGCTGGACCACATAGCTCACGCGGAATCCTTGATTGAGGAACGGTTGGACAATTTCGAGAGACAGTTTGCCGAGTTGGAGGAAGGAATGAATTTGGAGGACGAGGAAGGTTACCCGAAGACAAGGCAGACATTGCAACTTTTAATGAGAGATCTGGACACTTTAAAGAAGTTCAGCGAGTGGCCGATAGTTTGA
Protein Sequence
MGRKCTVQNCKSDSTRPEHVGVTFHKVPHHSDVRPKWISLCRISEDKSNAKVLYVCSRHFLRADFCSFKGKKYMLRQGVLPSVFPWDKSKLDAIKAEVTTKKEVEIPKKKEKKNKEKSKAENVSISKKDYDTTSESDESKIESDNLPKTDNSIQADEKDNPNADIKEETDAFDQHQRSQSTSAPTSPMIFLINSKIEVLDNNVWYTAKINEVDYEESEILIHFEHYSNKYDEWISMSSPRLRPIQPKLTEKYELGEKCMAISNDTKKFPATITNIIDTETYEVRFQDGLNQTIKVDKISKISKTKPAQASPLFEPIKSSKQERRDKKRKLNVAELFGKRCRSSHTEDKKMKTPSTSQPTEESTSSAPDAPDQKAIPIADSSMNLSDQWLPTFENGKPVGKDSKIESIDGVRKSVIVPDPRIPSNWERHLAQRSHGTSAGKWDTIFISPDNKKFRNKSEIKAYLEQNPNVDVSLDVFDFSIYRNGHKRKSIKHKSKTDNQAEPNEEPVKEEPVNNEEVSTPTVNLKIIFEDDSYKCPIEGCGKNFRRENLALMHVKHYHSEYTKYLDSTPNVADLAYARTVGENLDKSPGIVKPGTPKAAIDKTPVSAKVSKAAHMPAAEPKTPGNNSPNPEAKTRDAEIIKLLNQKVAEPDKDIQPLPSGLPSSMYPDIKLKDLLSKTEEIPHKDELNIKTLCASRPTHGIKTLLPVRSSQVSMENHEEKIIKRKRPPSDSLDTHKGKQPRHSTVSPPKSDHNQPTQQPPPPQKHPVASNQSSNSQSPRSDISAIPSAFDLAPPVGLRTSQPPPAVTPFDGVIIEGGKIIKLERMKQEEIINCTCGYTEEDGLMIQCELCLCWQHAHCNNIQKESEVPEKYICYICQHPVKERRSMKYLHDQDWLKQGTLPVASYHTKDDDELRKRFEKLKKCHDLTGGVHELRDYMHTLAYKLKIAEAKNHPKLYLWSKPWEKPKLPEKANVKDEESADSKVKIENMDHQYLKNEMAVEKQENQNDSMLMMILKDNKEDVPMLNDHNSLAPIIPKPEAAIDSDDCRLNLLDHIAHAESLIEERLDNFERQFAELEEGMNLEDEEGYPKTRQTLQLLMRDLDTLKKFSEWPIV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01307302;
90% Identity
iTF_01307302;
80% Identity
iTF_01307302;