Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 1.2 1.6e+04 -3.4 0.1 29 39 26 36 25 38 0.85

2 7 0.0046 60 4.4 0.0 20 45 76 101 71 104 0.87

3 7 0.00083 11 6.8 0.1 21 44 105 128 101 132 0.87

4 7 0.0012 16 6.2 0.0 21 45 133 157 128 160 0.90

5 7 0.00021 2.7 8.7 0.1 21 46 161 186 157 192 0.85

6 7 0.0031 40 5.0 0.1 21 45 189 213 185 217 0.90

7 7 0.0018 23 5.7 0.1 21 47 217 243 213 249 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	1.2	1.6e+04	-3.4	0.1	29	39	26	36	25	38	0.85
2	7	0.0046	60	4.4	0.0	20	45	76	101	71	104	0.87
3	7	0.00083	11	6.8	0.1	21	44	105	128	101	132	0.87
4	7	0.0012	16	6.2	0.0	21	45	133	157	128	160	0.90
5	7	0.00021	2.7	8.7	0.1	21	46	161	186	157	192	0.85
6	7	0.0031	40	5.0	0.1	21	45	189	213	185	217	0.90
7	7	0.0018	23	5.7	0.1	21	47	217	243	213	249	0.86

Coding Sequence: ATGTCATTTGTTCAGAAGAGTCATCTGACAATGCGTCGACGGACAGGAACGAGAAAAAATCGCTATCCACGCTACGTTTGTTATCCGAGGATTGATACTAACAGGAATGACAGTGAATTGACAGTACACCCGCGTATGTGCACGGATAAGAAATCATACTCATGCGACGTGTGTGACAAGGAGTTTATCAGTAATAGCCAACTGATAATACACCGGCGGACGCACACGGGTGAAACACCGTACGAATGTGACTTGTGCGGTAAGTCGTTCTCTCAAAGAAGCAATTTGACCAGTCACCTAAGGACGCATACGGGTGAAAGGCCGTACTCTTGTAACGTATGCTACAAGTCGTTCTCTCAAAAGTTCACTTTGGCCAATCACATGCGGACGCACACAGGTGAAAAACCGTACAATTGTGACTTGTGCGGTAAGTTGTTCTCGCAAAGAAGCAATTTGACCAGTCACCTAAGGACGCATACGGGTGAAAGGCCGTACTCTTGTAACGTATGCTACAAGTCGTTCTCTCAAAAGCTCACTTTGGCCAATCACCTGCGGACGCATACAGGTGAAAAACCGTACAATTGTGACAAATGTAATAAGTTGTTCTCGCAAAGAAGCAATTTGACCAGTCACCTGCGGACGCACACAGGTGAAAAACCGTACAATTGTGACAAATGTAATAAGTTGTTCTCGCAAAGAAGCAATTTGACCAGTCACCTGCGGACGCACACAGGTGAAAAGCCGTACCACTGCGACGTGTGA
Protein Sequence: MSFVQKSHLTMRRRTGTRKNRYPRYVCYPRIDTNRNDSELTVHPRMCTDKKSYSCDVCDKEFISNSQLIIHRRTHTGETPYECDLCGKSFSQRSNLTSHLRTHTGERPYSCNVCYKSFSQKFTLANHMRTHTGEKPYNCDLCGKLFSQRSNLTSHLRTHTGERPYSCNVCYKSFSQKLTLANHLRTHTGEKPYNCDKCNKLFSQRSNLTSHLRTHTGEKPYNCDKCNKLFSQRSNLTSHLRTHTGEKPYHCDV

Sequence clustering based on sequence similarity using MMseqs2