Rnym020175.1
Basic Information
- Insect
- Rhopalosiphum nymphaeae
- Gene Symbol
- Runx3
- Assembly
- GCA_036289425.1
- Location
- JAZAQC010000034.1:1647917-1656550[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 4.1e-61 2.1e-57 192.8 0.0 2 128 146 274 145 275 0.96
Sequence Information
- Coding Sequence
- ATGCGTGTGCCGTTACGGCGGCGACGGTACCGCGCGCCCCTCGCCGCCGCCGCGGACCCGCGACCGCGCGCGCCGCAACGACGAACGGCGGTACGGTCAATCAAAATCCCCGCCGCGCCGCCGCCGTCCCGCCGCCTGTCGTCGGCGGCGCGGTGGCGGGGGGTGCGAGGGGTGAAAAAAAACCCCGACGAAAAACACACTACCGTGTCTGGCGGCCGCAGCGGTGGTGACGGTGGTGGTGgtagcggcggcggcggcggtggtggtggtggtggtggcgttggttcggcggcggcggcgcgaGGTGGGGACGACATAACACGAGGTCCCGTCGTCCGCGTGCGGAATATTTCAGTTGTGCCGAGATCGGTGACGCGGTTTGTCGCGTTTTTGGACATCGACGCTGTGTACCAGAAATACGTGGCATGCATTCTCGAGGATGTGCGAGCCATCCACGGCAAGGAGATGGTGGCCACGGGCAGCCCATCGGTTTTCTGCTCAGTGTTACCAGGCCACTGGCGGTCTAACAAATCATTGCCGATACCGTTCAAAGTGGTCGTACTAGATGAGGTTCCTGACGGCGCGGTCGTCGTCGTACAAGCCGGAAACGACGAGAATCCGTCGGCCGACATGCGAAATTATCGAGCCCTGTCCGCCACTGGCATCGCCGTCTTTAACGACCTCCGATTTGTTGGTCGAAGTGGAAGAGgtaagcTGTTAACGCTCACCATCACAGTTCAATGCAAGGACCAAGCAGTGTTAGTAGCTAACTACGTAAAGGCCATTAAAATCACTGTCGACGGACCAAGGCTACCTCGATCGAACCATAGAGACGTGATCCACGGTTACGGTGGCATGTTCCCAATGCACGGTCCCCTGCCGCCTTACGGTATGATCATGGAGTACAAACGACTACTGGAGGGCGCAGCGTTGCCGGGGTCGCTCAACTACCAGTACATAGCGGCCAATTACTTCCAACTTCACAACGCCATGGAAGCGTCGCAGATGTATTGCGACATGCCGTCTCAGTCGGCGTTCAACTTCGCCGGCTACAACGGTCTACACGGTTTGCCGCCTACGCCGCCGAACACGGAGGAAGATCCGACAACGGCCGCACCGGCGGCGCAGGACGACTGCGGCGGCGGTAGCATCGTTCCCACGAAGCGACAACGACACGCTGCCGAGTCGGCTCGCGCAGTGACCACCACGGCGACCGCGACCGCGACCACGACCTGCTCGGACGACCGACTCCGGCCGGAGCCGTGCAAGCGGCCTAAACGCGAGTCCGCTCCCAGCCCGGACATCGACATCGTCAGCGTGGGCGGCGTCCGGTCGTCCAGCCCGGAAGTGCAGCTCAAACCCCGACAGGAGAAGATCTGGAGACCTTACGGCGCCACCGACGAATAG
- Protein Sequence
- MRVPLRRRRYRAPLAAAADPRPRAPQRRTAVRSIKIPAAPPPSRRLSSAARWRGVRGVKKNPDEKHTTVSGGRSGGDGGGGSGGGGGGGGGGGVGSAAAARGGDDITRGPVVRVRNISVVPRSVTRFVAFLDIDAVYQKYVACILEDVRAIHGKEMVATGSPSVFCSVLPGHWRSNKSLPIPFKVVVLDEVPDGAVVVVQAGNDENPSADMRNYRALSATGIAVFNDLRFVGRSGRGKLLTLTITVQCKDQAVLVANYVKAIKITVDGPRLPRSNHRDVIHGYGGMFPMHGPLPPYGMIMEYKRLLEGAALPGSLNYQYIAANYFQLHNAMEASQMYCDMPSQSAFNFAGYNGLHGLPPTPPNTEEDPTTAAPAAQDDCGGGSIVPTKRQRHAAESARAVTTTATATATTTCSDDRLRPEPCKRPKRESAPSPDIDIVSVGGVRSSSPEVQLKPRQEKIWRPYGATDE
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00340355;
- 90% Identity
- iTF_01031730;
- 80% Identity
- -