Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00065 5.2 8.6 0.0 25 43 137 155 127 160 0.86

2 6 9.8e-05 0.78 11.3 0.1 21 45 189 213 181 221 0.86

3 6 0.43 3.4e+03 -0.4 0.0 21 44 217 240 212 249 0.76

4 6 0.16 1.3e+03 1.0 0.1 18 46 241 269 238 275 0.77

5 6 0.23 1.8e+03 0.5 0.0 21 52 300 331 297 331 0.83

6 6 0.00014 1.1 10.7 0.2 21 45 328 352 324 355 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00065	5.2	8.6	0.0	25	43	137	155	127	160	0.86
2	6	9.8e-05	0.78	11.3	0.1	21	45	189	213	181	221	0.86
3	6	0.43	3.4e+03	-0.4	0.0	21	44	217	240	212	249	0.76
4	6	0.16	1.3e+03	1.0	0.1	18	46	241	269	238	275	0.77
5	6	0.23	1.8e+03	0.5	0.0	21	52	300	331	297	331	0.83
6	6	0.00014	1.1	10.7	0.2	21	45	328	352	324	355	0.91

Coding Sequence: ATGCAATTTATTCTCAATATTAATAGCTATTGTCGTCTTTGTCTAAGAGAAAAAGGTTCATTAAAGTTGTTTGAGTCTGATCCTTCTACATCTGTAGCTATTAAACTACTTCAGTGTTTTAATTTTAATGTTAAAAAAAATGAATCTTTATCACAGAAGATATGTTCTCAGTGTAAGATACAATTGGACAGTGCTTTTGAATTTAAGGAAAAATTGATCGCAACAGAAAACTTTTTGAAAAATGCAATTAAACAAACTGTAAACTCTGTGAAAGAATTATTCATCATCAGAAATGATACATTGCAGGAAGACCTCAAAACAGCAGATGGTGACAGTGACACTTGTGACTCAATTAATAAGTGTAGAAAAAGTGGAGTAATTAGTAATTCAACGGTAGAGGGAAGTGGCAATGTATGCCCAGTGTGCTTTAAAAGTTTCAAAACTTCATATCAGCTAAAAAGACACAAAGTTGTACATTCTAAAAGTGACAATTATGCTTGTAAACAATGTGGGAAATTTTTTTACCAAAAATGTACCTTAGAAGTCCATCAGAGAATACATAGTGGTGAGAAACCATATTTATGTAATACTTGTGGCAAATCTTTCAGACAATCATCGGCGCTCAAAAGACATATTTCATCTCATTTTGATGAACGGCCCTATAAATGTAAAGTATGTAATAAATCGTTCAAATTACAAGAAGTGCTTGCTTCACATTTAAGAACTCATGAAGAAAATAAATTTATTTGTCCCACTTGTGGTAAGTGTTATACCAACCATTCTTCACTATATAAACATTTAAAGATACACTCTGGAGATAAAAGGCATGCATGTAGTCATTGTCCCAAGCAATTTACTAGATCTGATTTACTTAATGAGCACATTAAAACACATACTGGTGAAAGACCATTTATATGTGATGCTTGTGGTTCTTGTTTTAGTAGTAAGTCAACACTCAGAGTGCATGTGATGATACATAAAAATGAGAAACCATTTCAGTGTCAATATTGTAGTAAATTATTTCGACAAAGTGGTTCCTTAAATCGACATATAAAGTGTCATACTGGATAA
Protein Sequence: MQFILNINSYCRLCLREKGSLKLFESDPSTSVAIKLLQCFNFNVKKNESLSQKICSQCKIQLDSAFEFKEKLIATENFLKNAIKQTVNSVKELFIIRNDTLQEDLKTADGDSDTCDSINKCRKSGVISNSTVEGSGNVCPVCFKSFKTSYQLKRHKVVHSKSDNYACKQCGKFFYQKCTLEVHQRIHSGEKPYLCNTCGKSFRQSSALKRHISSHFDERPYKCKVCNKSFKLQEVLASHLRTHEENKFICPTCGKCYTNHSSLYKHLKIHSGDKRHACSHCPKQFTRSDLLNEHIKTHTGERPFICDACGSCFSSKSTLRVHVMIHKNEKPFQCQYCSKLFRQSGSLNRHIKCHTG

Sequence clustering based on sequence similarity using MMseqs2