Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 2.9 4.9e+03 -1.3 0.0 27 46 63 82 61 88 0.76

2 8 0.00021 0.36 12.0 0.0 21 48 85 112 79 118 0.91

3 8 0.075 1.3e+02 3.8 0.1 21 47 142 168 135 175 0.72

4 8 0.12 2e+02 3.2 0.1 21 51 170 200 163 203 0.75

5 8 2.7 4.6e+03 -1.2 0.0 22 43 199 220 188 225 0.67

6 8 3.2e-05 0.054 14.6 0.0 21 52 226 257 218 259 0.87

7 8 0.2 3.5e+02 2.4 0.0 21 47 254 280 252 287 0.69

8 8 0.0035 6 8.0 0.1 21 45 282 306 277 309 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	2.9	4.9e+03	-1.3	0.0	27	46	63	82	61	88	0.76
2	8	0.00021	0.36	12.0	0.0	21	48	85	112	79	118	0.91
3	8	0.075	1.3e+02	3.8	0.1	21	47	142	168	135	175	0.72
4	8	0.12	2e+02	3.2	0.1	21	51	170	200	163	203	0.75
5	8	2.7	4.6e+03	-1.2	0.0	22	43	199	220	188	225	0.67
6	8	3.2e-05	0.054	14.6	0.0	21	52	226	257	218	259	0.87
7	8	0.2	3.5e+02	2.4	0.0	21	47	254	280	252	287	0.69
8	8	0.0035	6	8.0	0.1	21	45	282	306	277	309	0.89

Coding Sequence: ATGGATAAAGAAGAAATGTTTGAAATGGTCCAAATATGTGGAAGTCCAAAAGTCGAAATTAAACAAGAAGAGGTTGAATTTGATTCTGAAAATTTACATCACACTTTTGACATGAAAGAGGAGCTTCCTTTTCCGGAAACCAAACTTGTTAACGAAATTGTACTACATATCATCAAGCAATTCGAatgcgaaatttgtgactataaaagtgtcCACCAATACAGATTgaaagatcatttaaaaacccacactGGTGAGAAACCATTTAGTTGCAAAATTTGCAATCAAAAATTCACGCAAAGCGGAACGTTAACGCGGCACGTTAAAACACAACATTCTGACGAGAAACCGTACGGATGTGAGTTTTGTGAGTATAAAAGTAAGCGTAAGGGTGATTTGAGTGATCATGTGAAAAGTcacactggtgagaaaccgtttgaatgcaCTGTTTGTTACCATAAAAGTGCACGAAAAGGTGACTTTAGTGCTCACTTAAAAACCCACACTAATGAGAAACCGTacgtgtgtgaaatttgtgactacagtAGTGCACATAAGTACAGATTAAAGGATCACTTAAAAATTCACTCGGAGGATAAGCCATTCACTTGTACAAAGTGTGACTTCAAATCTgctttcaagaaaattttgaaagaacaCTTAAGGATTCATTCAGGTGAAAAGCCGTTTACATGTGAGATATGTAATCAGAAATTTAAGCAAATTGGAAGTTTGAAACGGCATATTAAAATTCATTCTGGCGAAAAACCGTTCGTATGTGACATTTGCGACTATAGGAGTACACGTAAGCATGATTTGAGTGATcacttaaaaactcatactggggagaaaccgtttgtttGTGAGTTTTGTTACTATTCAACTGCATTAAGGAGTAATTTGACAAGACATCTAAGAACCCACGCTGACTAA
Protein Sequence: MDKEEMFEMVQICGSPKVEIKQEEVEFDSENLHHTFDMKEELPFPETKLVNEIVLHIIKQFECEICDYKSVHQYRLKDHLKTHTGEKPFSCKICNQKFTQSGTLTRHVKTQHSDEKPYGCEFCEYKSKRKGDLSDHVKSHTGEKPFECTVCYHKSARKGDFSAHLKTHTNEKPYVCEICDYSSAHKYRLKDHLKIHSEDKPFTCTKCDFKSAFKKILKEHLRIHSGEKPFTCEICNQKFKQIGSLKRHIKIHSGEKPFVCDICDYRSTRKHDLSDHLKTHTGEKPFVCEFCYYSTALRSNLTRHLRTHAD

Sequence clustering based on sequence similarity using MMseqs2