Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.0089 15 6.8 0.1 22 46 87 111 83 113 0.91

2 5 0.0088 15 6.8 0.0 21 46 114 139 112 145 0.88

3 5 0.0017 2.9 9.1 0.0 20 46 169 195 166 201 0.89

4 5 0.6 1e+03 0.9 0.2 24 46 201 223 196 225 0.79

5 5 3.9e-05 0.068 14.3 0.0 17 45 223 251 218 254 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.0089	15	6.8	0.1	22	46	87	111	83	113	0.91
2	5	0.0088	15	6.8	0.0	21	46	114	139	112	145	0.88
3	5	0.0017	2.9	9.1	0.0	20	46	169	195	166	201	0.89
4	5	0.6	1e+03	0.9	0.2	24	46	201	223	196	225	0.79
5	5	3.9e-05	0.068	14.3	0.0	17	45	223	251	218	254	0.89

Coding Sequence: ATGGATATAATGCCAATTTCGGAACAGTTTCCGAAGATTGAAGAGAATACCAAtgatttacaaattaaaacagAAGAAATTGAAAGCACGGAAATCAAATTGGAAACTCTGCATCATTCAGTTGATATTAAAGAAGAGGACGCTGCGATCAAAAACTGCGAATTGGATTCTGAAGACGCTTCAATTGAAGAATGTGAATGGAACATTGATGAGGTTCAATATCCTAATAAACCAAATCTCTTcgtttgtgaaatttgcgataaaccgtttgcTTGCGAAGTGTGCAATTTCAAATGTACTCAAAAAAGTAATTTGAAAGCCCACTTAAAAATTCATACCGGGGAGAAGCCATTTACCTGTGACGTATGCCACTATAAATGTGCAGGCAAAGATAAGTTAGCCCGTCATTTAAAAgttcatactggtgagaaattGTTTGCTTGCGAAACTTGCGACTACAGGTGTGCACGCAAAGATAAGTTGCAACTccatttaaaaacccacaccAGCGAGAAATTATTTACGTGCAAAATTTGTGGTTCCAAATTTACGCAAAGAGATAATTTAAATATGCATTTACGAATTCATAACGGCGAGAAACGGTTTGGATGTGAAGTTTGCGgttataaatgtgtacaaaaaGTTCATTTAACAAGACACTTAAAAGTTCATTCGGACGAGGAGAAACCTTATACATGCGAAATTTGTGGCCACAAATTCCGagaaaaaggaaatttaaaaacgcatttAAGAACACATACCGGATAG
Protein Sequence: MDIMPISEQFPKIEENTNDLQIKTEEIESTEIKLETLHHSVDIKEEDAAIKNCELDSEDASIEECEWNIDEVQYPNKPNLFVCEICDKPFACEVCNFKCTQKSNLKAHLKIHTGEKPFTCDVCHYKCAGKDKLARHLKVHTGEKLFACETCDYRCARKDKLQLHLKTHTSEKLFTCKICGSKFTQRDNLNMHLRIHNGEKRFGCEVCGYKCVQKVHLTRHLKVHSDEEKPYTCEICGHKFREKGNLKTHLRTHTG

Sequence clustering based on sequence similarity using MMseqs2