Basic Information

Gene Symbol
-
Assembly
GCA_958510855.1
Location
OY294038.1:14239977-14252790[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.13 8.9 8.0 3.4 3 23 101 121 99 121 0.98
2 12 0.0011 0.072 14.5 0.5 1 23 127 149 127 149 0.97
3 12 0.076 5.1 8.7 1.3 3 23 157 177 155 177 0.97
4 12 2.7e-05 0.0018 19.6 0.9 1 23 183 205 183 205 0.97
5 12 0.16 10 7.7 1.0 1 23 211 233 211 233 0.96
6 12 0.0011 0.073 14.5 0.6 1 23 307 329 307 329 0.97
7 12 0.049 3.3 9.3 0.7 3 23 337 357 335 357 0.90
8 12 7.7e-05 0.0051 18.2 1.1 1 23 363 385 363 385 0.98
9 12 0.00034 0.023 16.1 2.1 1 23 391 413 391 413 0.98
10 12 3e-05 0.002 19.4 2.3 1 23 419 441 419 441 0.98
11 12 0.003 0.2 13.2 1.6 1 23 453 475 453 475 0.98
12 12 0.0058 0.39 12.2 0.9 1 23 481 503 481 503 0.98

Sequence Information

Coding Sequence
ATGGAAAATCAAATTGAAAGTGTTACTATAATAGAAAGGGAGATAAAGGAAGAACCTATAtttaatgaagaagaagaatcctTGGAATTAGAATCTTCGGAGTCCATGATCGAAAAAGATTATAATTTCGAAACATCGGATGTTACCATTGATCGTCCCACTGATGAAATATCAGGCAAGATGCTTTGTTTATTCAATAATAGTTTCCaagagGAAAAAAATCCCAATCCAGACCATGTAGATTATTTTTTGGATGTTCGTCCATACTTAAATTCTGGCACCCAAACAAGTCAGTTCGGTTGTCATATCTGTGGCAGTCAATTTACACTTAAGAAAGTTTTACATCAGcacttaaaaattcatacaggAGAAAAACAATTTGCATGTGGAAGTTGTGACTACAAAACAGTTAAGAAAGGTAACTTGCAACGCCACGAGAGGATTCACACAGGGGAACGGCCTTTTGGATGCACAACTTGTGCATCTACATTTCAAGACGAGAGTGCATTACATAAGCATCTAAAAATTCACGGTCATAGAGATTGTTTCATGTGTACAATTTGCCAGAAAACATTTTATAGTAAGGGTGCACTAAAATTACACGAAAAGATTCATACAGGCGATAAACCATTTGCGTGTCAATTTTGTGACTATAGGGCTCTACGATCGGGTCACTTGATAAATCACTTAAAAGTTCACGCAGAAACGAAACCGTTTTTAAGTGAAAAAAGTACCAGTAAGACAATCGGACAGCAACGTTCCATATTAAACCACTCGGAAAGAAATCTAGAACTGTGTGAGTGCGAAACTTGCGGATACAAAACTGTTCACAAAGaggAAGAGGAGATCAAATCAGACCCCTTAGATTACTTTTTTGACGTTCAGTCGTATATAAATTCTCAAGAAGAACAAAAACCATTTGCATGTGGACTTTGCGAGTACCGAACGACGAAGAAAGGAAATCTGCAACGACACGAAAAGATTCACACAGGAGAAAGACCATTTGCATGTATACTATGTGATtctaaatttaaagaaaacagTGCGTTAcagaaacattttaaaatacacaCCGGTAAGGATTCATTTAAGTGCGAGGTTTGTAGCAATAATTTTTCTACCAAGGGTTCGTTAAAACTACATCTAAAAATTCATTCCGGGGAGAGGTTATTCAAGTGTGAATTTTGCGACTACAGAGCCATAAGGCAAAGTCACTTACGGAGTCATTTATTGGTTCACACAAATGAAAAACCCTTTTCCTGTGAAATCTGTCACTATGCGACCAGAAGTTCGACAAACTTACAAAGACATTTAAAGATTCATGtagataaaactttaatttcaatTGAAAAACCATATCAGTGTGAAACTTGCGATTACAAAACTGCcgataaaagttattttttgcaACATTCCAAAATTCACACTGGAGAGAAACCGTTTTCGTGTTATATTTGTGACTATGCGACTCTAAGGAGCAGAGATTTAAAAAGACACTTAAAAATTCACTCGAAAGACGAACAATATGAATGTGCAAGTTGTGGTTATAAAACGATAGCAATTCAAGAACCAACTTCTAATGACTATCTTTCAACTGATCACATCTCAAAGTTTAACGAAATCCTGGTGGCTAATACAGAGTTCAGACCACAAGAAGCTTTATTGATGTGGCATATGTACAATGATATAGTTTCAGTGAGTACACGGCATATTCAAATTCTGCCTGCGACAGCAACTGACAATATCACTCACTGGATATGCACATATTACGATGGTTCTGTAATACATATATATGACAGCGCCAATAATTATAAGGTTAATAATCTTACTTCTGATCAGCTACGGTTTCTTGATCGGTTATTTCCAAATAAACCTCCCATTATATACGAAGATGTTCAACaacaaaccaatggcgttgaTTGCGGTGTGTTTGCGATAGCTTTCGCTGTTGCTATAGCTAACGGCATGAATCCATCGCAACAGATATTCAATATTCCGGTGATGCGGAAccatttaaaagatatttttaatcagaatttacttttaaggttttctgttaatattacaaattgcgaGGTTCCTTCAATTATGGCAAGAGATAGAACAAACCCAAACAAAAGAAAACGATCAAACAGTATGTTTTTAGGCATAGAAAGTGGCACAAAGAGAAAAAGGCAAGAGAAGAATGCGGAGGTTAACGCAACAGAAACTAAACAACAAAGAAATGCAAAGTTAGAATGTGAACGAGaaagaatgaaaacaatgagagcattggaaacagaagaaaaaagaaatgcgaggttagaaaattgttttctaaaatatatcgagCTTGTGAACGAAAACACCGATCGTGATCAGGAGGAGAACATCGGTTCTGCAACTAACAACGGCGATGATGTTTCTGCGGTTGGCAATATAAGACTGTGGATAGAGTTCCCCAACACCGTGATCGGTCGGAAGAGACGCGTAAAAGCCAGACCTCATGTGATGTGCAAGTCAACTGTAATTAGTCGAGACTGGACGCATATTAATACTTGCATGGCCAACATATCTCTTGATGTTGAAATCAAATGCAAACGAAGGCAGTTTCCGCTAGTCCCCGCTTGCGCGTTGACCATACACAAATCGCAAGGCGGGACGGGACGTTCGACGAAGTTGTCTTTCAGTATATGA
Protein Sequence
MENQIESVTIIEREIKEEPIFNEEEESLELESSESMIEKDYNFETSDVTIDRPTDEISGKMLCLFNNSFQEEKNPNPDHVDYFLDVRPYLNSGTQTSQFGCHICGSQFTLKKVLHQHLKIHTGEKQFACGSCDYKTVKKGNLQRHERIHTGERPFGCTTCASTFQDESALHKHLKIHGHRDCFMCTICQKTFYSKGALKLHEKIHTGDKPFACQFCDYRALRSGHLINHLKVHAETKPFLSEKSTSKTIGQQRSILNHSERNLELCECETCGYKTVHKEEEEIKSDPLDYFFDVQSYINSQEEQKPFACGLCEYRTTKKGNLQRHEKIHTGERPFACILCDSKFKENSALQKHFKIHTGKDSFKCEVCSNNFSTKGSLKLHLKIHSGERLFKCEFCDYRAIRQSHLRSHLLVHTNEKPFSCEICHYATRSSTNLQRHLKIHVDKTLISIEKPYQCETCDYKTADKSYFLQHSKIHTGEKPFSCYICDYATLRSRDLKRHLKIHSKDEQYECASCGYKTIAIQEPTSNDYLSTDHISKFNEILVANTEFRPQEALLMWHMYNDIVSVSTRHIQILPATATDNITHWICTYYDGSVIHIYDSANNYKVNNLTSDQLRFLDRLFPNKPPIIYEDVQQQTNGVDCGVFAIAFAVAIANGMNPSQQIFNIPVMRNHLKDIFNQNLLLRFSVNITNCEVPSIMARDRTNPNKRKRSNSMFLGIESGTKRKRQEKNAEVNATETKQQRNAKLECERERMKTMRALETEEKRNARLENCFLKYIELVNENTDRDQEENIGSATNNGDDVSAVGNIRLWIEFPNTVIGRKRRVKARPHVMCKSTVISRDWTHINTCMANISLDVEIKCKRRQFPLVPACALTIHKSQGGTGRSTKLSFSI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01294625;
90% Identity
iTF_01294625;
80% Identity
iTF_01294625;