Basic Information

Gene Symbol
E2f5
Assembly
GCA_958510855.1
Location
OY294039.1:17420096-17420938[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.3e-28 4.5e-24 84.9 0.1 2 64 10 73 9 74 0.98
2 2 2.3 1.7e+04 -3.4 0.0 29 38 188 197 183 200 0.78

Sequence Information

Coding Sequence
ATGGCAGAAGTTGCCAATAGTCGCTTTGAAAAATCGTTAGGTTTGTTGACGATAAGATTCGTGGAATTACTACAAAACTCTCAAGGTGGTGTATTGGATTTGAAAATTGCTGCCGATTTGTTAGATGTGCGCCAAAAGAGACGAATATATGACATTACCAACGTTCTTGAAGGAATTGgtttaattgaaaagaaaagtAAGAACATTATCCAGTGGAAACCGTTAGCTCATAAGGATCCGCTAGGCGAGTTTAATGAGGAAGAGTATACGTTGAAAGTTGCAAATTTAAGAACTGAAATACAAAAGTTAGAAGATCACGAGGTCGAGTTAGACAGACTAACGTACCTAATCGAACAGAGCATTAAAAACGTGACCGAAGATATCGATACTAAAGATTATTTATATGCCACGTACGAAGATCTTCAAGAATGCTTTGGTGAAGGCGAAGAAGTTATAATTTTGAACGCCCCCTTAAACAGTGTATTCCAGTTAGACGATTCTCCTTCCTTACCAAACCTAAAGGTCACATCCAACGTAATCCCAACAGTAGCCAGACTTAAAGTTGGTCAAAACTTGCAAACAAAGAAAAGGAAATTTGAAGAAGCGTTCAAACCGGAAGATTTAGAAGAGGAATGGGAGGATGACGATTTACATACTgctaaaattttgttcaaaaatttgcCAAGCTGGTTAGATAGTACTTCCGATTCCGATAGTGATAATAATTTATCGGAACACATGGAAAACGAACAATTTGTTAGATTATTTCCAACATTTACAAACAACGACTTTAAGTTCAATTTGACCGAAAATGAAGGTGCCATGGATTTATTCGATATGTAG
Protein Sequence
MAEVANSRFEKSLGLLTIRFVELLQNSQGGVLDLKIAADLLDVRQKRRIYDITNVLEGIGLIEKKSKNIIQWKPLAHKDPLGEFNEEEYTLKVANLRTEIQKLEDHEVELDRLTYLIEQSIKNVTEDIDTKDYLYATYEDLQECFGEGEEVIILNAPLNSVFQLDDSPSLPNLKVTSNVIPTVARLKVGQNLQTKKRKFEEAFKPEDLEEEWEDDDLHTAKILFKNLPSWLDSTSDSDSDNNLSEHMENEQFVRLFPTFTNNDFKFNLTENEGAMDLFDM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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