Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 9.4 4.3e+03 -1.2 0.1 25 45 60 80 48 83 0.67

2 7 0.0037 1.7 9.7 0.0 21 52 84 115 79 117 0.83

3 7 0.07 32 5.6 0.0 21 52 112 143 108 145 0.88

4 7 0.34 1.5e+02 3.4 0.1 21 52 140 171 136 173 0.86

5 7 1.2 5.4e+02 1.7 0.2 21 44 168 191 164 195 0.75

6 7 0.097 44 5.2 0.4 21 45 196 220 180 223 0.82

7 7 0.0019 0.86 10.6 0.3 21 48 224 251 220 254 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	9.4	4.3e+03	-1.2	0.1	25	45	60	80	48	83	0.67
2	7	0.0037	1.7	9.7	0.0	21	52	84	115	79	117	0.83
3	7	0.07	32	5.6	0.0	21	52	112	143	108	145	0.88
4	7	0.34	1.5e+02	3.4	0.1	21	52	140	171	136	173	0.86
5	7	1.2	5.4e+02	1.7	0.2	21	44	168	191	164	195	0.75
6	7	0.097	44	5.2	0.4	21	45	196	220	180	223	0.82
7	7	0.0019	0.86	10.6	0.3	21	48	224	251	220	254	0.85

Coding Sequence: ATGGAACGGATCGACGAAGTATCCGAACCTCCAGATAATTCTAGTAGCTACGAAATTAAAGTAGAAGATGTGAAGTTTAATTTAGAAGATTTACATCACTCGATAGACATTAAAGACGAGAGCGATGCTGAACAACTACCTCTGGAGAAACCAGTAAGAAAAACTAAAAACTCAAATTTTATTTGTCAGTTTTGTGATTATAAATGTGAACAGAAATCAATTTTAATAAGACATTTAAGAACTCACACAGGCGAGAAACCTTTTGTTTGTGAGATTTGTGACTATAAAAGTGTACAAAAGGATAATTTAAAAAAACATTTAAGAACTCACACAGGCGAGAAACCTTTTGTTTGTGATTTTTGTGACTCTAAATGGGCACGAAGTTCAGATTTAAAAACACATTTAAGAATTCACACAGGCGAGAAACCTTTTGTTTGTGAGTTTTGTGATTATAAATGTGCACAAAGAGGAGATTTAAAAGAACATTTAAGAATTCACACAGGCGAGAAACCTTTTGCATGTGAGATTTGTGACTATAAATGTGCACATAAGGCATATTTAAAAGAACATTTAAGAACTCACACAGGCGAGAAACCTTTTGCTTGTGAGTTTTGTGACTATAAATGTGCTCGAAAATCATCTTTAAAACGACATTTAAGAACTCACACAGGGGAGAAACCTTTTGCTTGTGAGATTTGTGACTATAATTGTGCTAGTAAATCAACTTTAAAAAAACATTTAGAAAGAAGACACGGGGGAGTAGCCTTTTGTTTGTGA
Protein Sequence: MERIDEVSEPPDNSSSYEIKVEDVKFNLEDLHHSIDIKDESDAEQLPLEKPVRKTKNSNFICQFCDYKCEQKSILIRHLRTHTGEKPFVCEICDYKSVQKDNLKKHLRTHTGEKPFVCDFCDSKWARSSDLKTHLRIHTGEKPFVCEFCDYKCAQRGDLKEHLRIHTGEKPFACEICDYKCAHKAYLKEHLRTHTGEKPFACEFCDYKCARKSSLKRHLRTHTGEKPFACEICDYNCASKSTLKKHLERRHGGVAFCL

Sequence clustering based on sequence similarity using MMseqs2