Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0012 0.53 11.3 0.0 21 52 79 110 63 112 0.88

2 7 0.044 20 6.3 0.5 21 45 135 159 127 163 0.86

3 7 0.61 2.8e+02 2.6 0.1 25 52 167 194 161 196 0.85

4 7 4.2 1.9e+03 -0.1 0.1 21 45 191 215 174 224 0.78

5 7 1.8 8.3e+02 1.1 0.0 21 45 219 243 209 252 0.74

6 7 0.84 3.8e+02 2.2 0.2 21 47 247 273 238 280 0.78

7 7 0.0002 0.089 13.8 0.0 4 49 287 331 285 334 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0012	0.53	11.3	0.0	21	52	79	110	63	112	0.88
2	7	0.044	20	6.3	0.5	21	45	135	159	127	163	0.86
3	7	0.61	2.8e+02	2.6	0.1	25	52	167	194	161	196	0.85
4	7	4.2	1.9e+03	-0.1	0.1	21	45	191	215	174	224	0.78
5	7	1.8	8.3e+02	1.1	0.0	21	45	219	243	209	252	0.74
6	7	0.84	3.8e+02	2.2	0.2	21	47	247	273	238	280	0.78
7	7	0.0002	0.089	13.8	0.0	4	49	287	331	285	334	0.85

Coding Sequence: ATGGAAAACGTTAGCAATTCAAGCTGTAAAGTGGAAGTTAAAACGGAAGAATGTGAAGATTTAAATTTTAATTTGGAACAATTGCATCATTCAGTAGATATTAAGGAGGAAGAAAGAGATGGAGAGAAACCTGCAAAAAACTATGGTATTCGAGGAAAATTTTTACATTGTGAGATTTGTGGCTATAAATCTGCTCAAAAATCATCTTTAAAAGAACATATAAAAACTCATACTGGTGAAAAACCATTTGCTTGTGAGATTTGTGGCTCTAAATGGGCGCAAAAATCAAATTTAAAAAAGCATTTAAGAACTCACACGGGGGTGAAACCGTTTATGTGTGAGGTTTGTGATTATAAAAGTGTTCAAAAATCATCTTTAAAAGAACATATAAAAACTCACACAGGCGAGAAACCATTTTCTTGTGAGATTTGTAACCATAAATGTGCACGCAGATCAAGTTTAAGAAAACATTTAAAAACTCACACGGAGGAGTATATGTTTACGTGTGAGTTGTGTGACTATAAATGTAGACACAAATCAAGTTTAAAGGGGCATCTAAAAGTTCATACAGGAGAAAAACCGTTTGTTTGTGAGTTTTGTGACTATAAATGTGTTCAGAAATTAACTCTAAAAGAACATGTGAAAACTCACACAGGCGAGAAACCGTTTGCTTGTGAGGTTTGTGATCATAAATTTGCACGAAGATCAGTTTTAAAAGATCATTTAAGAACTCACACGGGGGAAAAACCGTTTGCTTGTGGGAATTGTGACTATAAATGTGCTCGCAGATCAGTTTTAAGAGAACATTTAAAAACTCATACAGGGGAAAAACCGTTTGCTTGTGAGTTTTGTGGCTATAAAGGTGCTAAAAAGTCGTCCTTAACAGAACATTTAAAAACTCACTCAGGGGAAAAACCGTTTGCTTGTGGGGTTTGTAATTATAAATTTGCTCAAAAATCGTCTTTAAAAAGACATTTAAATATTCACAATTTCAAAGAAAACGACGATGCCACTCGCTTATTTTAA
Protein Sequence: MENVSNSSCKVEVKTEECEDLNFNLEQLHHSVDIKEEERDGEKPAKNYGIRGKFLHCEICGYKSAQKSSLKEHIKTHTGEKPFACEICGSKWAQKSNLKKHLRTHTGVKPFMCEVCDYKSVQKSSLKEHIKTHTGEKPFSCEICNHKCARRSSLRKHLKTHTEEYMFTCELCDYKCRHKSSLKGHLKVHTGEKPFVCEFCDYKCVQKLTLKEHVKTHTGEKPFACEVCDHKFARRSVLKDHLRTHTGEKPFACGNCDYKCARRSVLREHLKTHTGEKPFACEFCGYKGAKKSSLTEHLKTHSGEKPFACGVCNYKFAQKSSLKRHLNIHNFKENDDATRLF

Sequence clustering based on sequence similarity using MMseqs2