Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.041 18 6.4 0.6 21 44 66 89 60 93 0.77

2 6 0.0073 3.3 8.8 0.0 21 44 94 117 90 122 0.89

3 6 0.039 17 6.4 0.1 21 45 122 146 118 150 0.83

4 6 0.13 60 4.7 0.1 22 44 151 173 146 177 0.82

5 6 0.31 1.4e+02 3.6 0.3 21 43 178 200 174 206 0.76

6 6 0.039 18 6.4 0.0 21 46 206 231 198 241 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.041	18	6.4	0.6	21	44	66	89	60	93	0.77
2	6	0.0073	3.3	8.8	0.0	21	44	94	117	90	122	0.89
3	6	0.039	17	6.4	0.1	21	45	122	146	118	150	0.83
4	6	0.13	60	4.7	0.1	22	44	151	173	146	177	0.82
5	6	0.31	1.4e+02	3.6	0.3	21	43	178	200	174	206	0.76
6	6	0.039	18	6.4	0.0	21	46	206	231	198	241	0.81

Coding Sequence: ATGGAAATTAAATTGGAAGATCTTCATCATTCAATTGACATTAAAGAAGAAGATGCCCCGATTGAACAAGTGAATATTAAAGCTGAAGAAAAACTTCAGTCAGGCATTACCGGAGGAAATCTCTTCTTGTGTAAAACTTGCGGTTACAAATGTAAACGAAAAAGTGTTCTAGAAATTCACTTAAGGACTCATACCGGTGAGAAACCATTTACGTGTGAAATTTGTGATTATAAGTGCGTACGAAAACAGTGTTTAAAAATACATTTACAAACTCACACTAACGAAAAACCATTTTCGTGTGACATTTGTGGCTACAAATGCAGACAAAAAAAAGATTTAAAAATGCATTGGAGAGTTCATACCGGCGAGAAACCTTATACGTGTGACATTTGTGACCTTAAATGTGTGCATAAATCAAACCTAAACCTTCATTTAAAAACTCACATAGGAGAAAAACCTTTTGCGTGTGAAATTTGCAATTACAAAACTACCCGAAAGACGAATTTAAAAACGCATTTTCGAACTCATACTGGCGAGAAACCATTTACGTGTGAAATGTGTGACTACAAATGCACACGTAGGGATAGGTTAAAGGAACATGTACGAACTCATACCGGTGAAAAGCCGTTTACGTGTTCGCTTTGCGTTTTTAAATGTGCACTTAAAGTGGGTTTAAAGAAACATTTAGAAACTCATACTAGCGAGAAAAGACACCTGGCCAACTTTTGA
Protein Sequence: MEIKLEDLHHSIDIKEEDAPIEQVNIKAEEKLQSGITGGNLFLCKTCGYKCKRKSVLEIHLRTHTGEKPFTCEICDYKCVRKQCLKIHLQTHTNEKPFSCDICGYKCRQKKDLKMHWRVHTGEKPYTCDICDLKCVHKSNLNLHLKTHIGEKPFACEICNYKTTRKTNLKTHFRTHTGEKPFTCEMCDYKCTRRDRLKEHVRTHTGEKPFTCSLCVFKCALKVGLKKHLETHTSEKRHLANF

Sequence clustering based on sequence similarity using MMseqs2