Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.046 21 6.2 0.0 21 47 84 110 79 115 0.84

2 7 0.021 9.7 7.3 0.0 21 52 112 143 105 144 0.83

3 7 0.52 2.3e+02 2.8 0.2 21 45 140 164 138 167 0.77

4 7 0.024 11 7.1 0.0 21 44 168 191 164 195 0.89

5 7 0.37 1.7e+02 3.3 0.1 21 45 196 220 192 223 0.85

6 7 0.0067 3 8.9 0.1 21 47 224 250 220 255 0.86

7 7 0.65 2.9e+02 2.5 0.0 21 45 252 276 248 278 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.046	21	6.2	0.0	21	47	84	110	79	115	0.84
2	7	0.021	9.7	7.3	0.0	21	52	112	143	105	144	0.83
3	7	0.52	2.3e+02	2.8	0.2	21	45	140	164	138	167	0.77
4	7	0.024	11	7.1	0.0	21	44	168	191	164	195	0.89
5	7	0.37	1.7e+02	3.3	0.1	21	45	196	220	192	223	0.85
6	7	0.0067	3	8.9	0.1	21	47	224	250	220	255	0.86
7	7	0.65	2.9e+02	2.5	0.0	21	45	252	276	248	278	0.85

Coding Sequence: ATGGATACTCCGTATAATTCAAAATTCCTAGTTGAAGTTAAAACGGAGGAATGGGAAGACAAAAAATTTAATTTACAAGATCTACATCATTCAATAGATATTAAGGAGGAAGAGAGCAATGGGGAAGCATTGATAGAGGAGAAATCTGCAAGAAATACTGGTATTCGAAAGAAATTGTTTAACTGTGAAGTTTGTGGTTATAAATGTGCACATAAATCACATTTACTGATCCATTTAAGAACTCACACGGGTGAGAAACCTTTTATTTGTGAGATTTGTGCGTATAAATGTGCTCAAAAATCATTTTTAAAAAAACATTTGAAAACTCACACAGGCGAGAAACCATTTGCATGTGAGATTTGTGACTATAAATGTGCTCATAAATCAAATTTAAAAGTACATTTAAAAATCCACACAGGCGAAAAACCGTTTGCTTGTGAGATATGTAACTATAAATGTGCTCATAAATCACATTTAAAAGAACATTTAAAAACTCACACAGGCGAGAAACCATTTGCATGTGAGATTTGTGACTATAAATGTACTCAAAAATCAAATTTGAAGGAACATTTTAAAACTCACACAGGGGAAAAACCTTTTGGTTGTGAGATTTGTGACTTCAAATGTGCTCATAGATCATCGTTAAGAGAACATCTAAAAACTCACACAGGGGAAAAACCCTTTGCTTGTGAGGTTTGTGACTATAAATGTACTCAAAAAGCAAATTTAAAACAACATTTAAAAACTCACACAGGCGAGAAACCCTTCGATTGTGGGATTTGTGACTATAAATGTGCCCATAAAAAATCTTTAAAAGAACATTTAAAAAATCACAAATGA
Protein Sequence: MDTPYNSKFLVEVKTEEWEDKKFNLQDLHHSIDIKEEESNGEALIEEKSARNTGIRKKLFNCEVCGYKCAHKSHLLIHLRTHTGEKPFICEICAYKCAQKSFLKKHLKTHTGEKPFACEICDYKCAHKSNLKVHLKIHTGEKPFACEICNYKCAHKSHLKEHLKTHTGEKPFACEICDYKCTQKSNLKEHFKTHTGEKPFGCEICDFKCAHRSSLREHLKTHTGEKPFACEVCDYKCTQKANLKQHLKTHTGEKPFDCGICDYKCAHKKSLKEHLKNHK

Sequence clustering based on sequence similarity using MMseqs2