Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.91 4.1e+02 2.0 0.4 20 45 59 84 50 87 0.73

2 6 0.00041 0.18 12.8 0.0 21 51 88 118 80 119 0.88

3 6 0.01 4.7 8.3 0.1 21 46 116 141 113 147 0.84

4 6 0.96 4.3e+02 2.0 0.1 21 44 144 167 140 171 0.73

5 6 0.0004 0.18 12.8 0.1 21 47 172 198 168 203 0.81

6 6 0.099 45 5.1 0.1 22 46 201 225 197 227 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.91	4.1e+02	2.0	0.4	20	45	59	84	50	87	0.73
2	6	0.00041	0.18	12.8	0.0	21	51	88	118	80	119	0.88
3	6	0.01	4.7	8.3	0.1	21	46	116	141	113	147	0.84
4	6	0.96	4.3e+02	2.0	0.1	21	44	144	167	140	171	0.73
5	6	0.0004	0.18	12.8	0.1	21	47	172	198	168	203	0.81
6	6	0.099	45	5.1	0.1	22	46	201	225	197	227	0.89

Coding Sequence: ATGGAAAACATTAGCAATAATTTTGAAATTTCGGATAATGCAAGCTGCAAAATGGAAGTTAAAACGGAGGAATTTGAAGACTTAAAATTTAAATTAGAAGATTCACTTGATATTAAGGAGGAAGATTGCGATGGAGAAGCATTATTTGAGGAGAAACCTGCAAAACAAACCGCCATTCGAGAGAAATCATTCCATTGTGAGGTTTGTGACTATAAATGTGCACGAAAATCGAGATTAAAAGACCACTTAAAAACTCACACCGGAGAAAAGCCGTTAGCTTGTGAGGTGTGTGACTATAAATGCGCGCAAAGTTCAAATTTAAAATCACATTTAAAAATTCACTCAGGGGAAAAACCGTTTAATTGTGAAATTTGTGACTATAAATGTTTACGAAAATCAAGATTAAAAGACCATTTAAAAACTCACACCGGGGAAAAACCATTTCATTGTGAGATTTGTGACTATAAATGTGCACACAAATCACATTTAAAAGATCATTTAAAAACTCACACAGGCGAAAAACCTTATGCTTGTCCGATTTGTGACTATAAATGTGTTCAAAAATCAGATTTAAAAAAGCATTTAAAAACTCACACAGGCGATAAACCTTTTGCTTGTGAGTTCTGTGACTATAAATGCGCACAAAGATCAAATTTAAAAAATCATTTAAAAATTCACAGGTGA
Protein Sequence: MENISNNFEISDNASCKMEVKTEEFEDLKFKLEDSLDIKEEDCDGEALFEEKPAKQTAIREKSFHCEVCDYKCARKSRLKDHLKTHTGEKPLACEVCDYKCAQSSNLKSHLKIHSGEKPFNCEICDYKCLRKSRLKDHLKTHTGEKPFHCEICDYKCAHKSHLKDHLKTHTGEKPYACPICDYKCVQKSDLKKHLKTHTGDKPFACEFCDYKCAQRSNLKNHLKIHR

Sequence clustering based on sequence similarity using MMseqs2