Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.023 11 7.1 0.0 21 51 92 122 88 123 0.86

2 7 0.00062 0.28 12.2 0.1 21 45 120 144 117 151 0.86

3 7 0.21 96 4.1 0.1 21 44 148 171 144 175 0.72

4 7 0.24 1.1e+02 3.9 0.2 21 45 176 200 172 207 0.82

5 7 0.028 13 6.9 0.0 21 45 204 228 201 234 0.90

6 7 0.18 81 4.3 0.1 22 46 233 257 228 263 0.76

7 7 0.035 16 6.6 0.1 21 45 260 284 256 287 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.023	11	7.1	0.0	21	51	92	122	88	123	0.86
2	7	0.00062	0.28	12.2	0.1	21	45	120	144	117	151	0.86
3	7	0.21	96	4.1	0.1	21	44	148	171	144	175	0.72
4	7	0.24	1.1e+02	3.9	0.2	21	45	176	200	172	207	0.82
5	7	0.028	13	6.9	0.0	21	45	204	228	201	234	0.90
6	7	0.18	81	4.3	0.1	22	46	233	257	228	263	0.76
7	7	0.035	16	6.6	0.1	21	45	260	284	256	287	0.90

Coding Sequence: ATGGAAAATTCATATAATTTAAGTAGCAGTTATAAAATTAAAACGGAGGAGGTAGAAGATGTGAAGTTTAATGTAGAAGATTTGCATCATTCGATAGACATTAAGGAAGATAGTGATAATGAAGAATTAGGGGAAGAGAAAAACGGTGTCCAGGATTGTGGTTTAAACTTCCGTTTACTACCTCAAACTAACAAAAGACAATTTGCTTGTCAATTTTGTGAGTATAAAGGTGTAACAAAATCAAGTTTACGGATTCATTTAAGAATACACACCGGTGAAAAACCATTTGCTTGTGGAATTTGTGACTATAAATGTTCACAAAATTCATCTTTAAAAGATCATTTAAAAATTCACACCGGGGAAAAACCGTTTGCTTGTTCAATTTGTGATTATAAAAGTACACATAAAAGAAATTTAAAAAGGCACTTGTATACTCACACCGGCGAGAAACCATACACGTGTGATATTTGCGGCTATAAGTGTTCAGTAAACTCCTCTTTAAAAGATCATTTAACGACCCACACCGGCGAGAAACCGCGTGCTTGCGATATTTGTGATTATAAATGTACTCAATTAACGCGGTTAAAAGAACACATAAAAACTCACACCGGAGAAAAACCGTATGCGTGTGATATTTGTGACTATAAATGTGCACAAAAGATGAATTTAAAAAGTCATGTAAAAACTCATACTGGTGAAAAACTGCACGCGTGTGAAATTTGTGATTATAAATTTGCAGCGAAATCATCTTTAAGAAGGCACTTGAGAACTCACACCGGTGAAAAACCATTCGCTTGTGATATTTGTTCGTATAAAAGTGCGCAAAGTTATCAGTTACAAATGCATTTAAAAAGTCACAATAAGGGATTTTAA
Protein Sequence: MENSYNLSSSYKIKTEEVEDVKFNVEDLHHSIDIKEDSDNEELGEEKNGVQDCGLNFRLLPQTNKRQFACQFCEYKGVTKSSLRIHLRIHTGEKPFACGICDYKCSQNSSLKDHLKIHTGEKPFACSICDYKSTHKRNLKRHLYTHTGEKPYTCDICGYKCSVNSSLKDHLTTHTGEKPRACDICDYKCTQLTRLKEHIKTHTGEKPYACDICDYKCAQKMNLKSHVKTHTGEKLHACEICDYKFAAKSSLRRHLRTHTGEKPFACDICSYKSAQSYQLQMHLKSHNKGF

Sequence clustering based on sequence similarity using MMseqs2