Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.2 88 4.2 0.0 21 45 114 138 108 142 0.88

2 8 0.0052 2.3 9.2 0.2 21 52 142 173 138 174 0.86

3 8 0.84 3.8e+02 2.1 0.1 22 45 171 194 168 197 0.86

4 8 0.12 54 4.9 0.1 21 46 198 223 194 230 0.83

5 8 0.025 11 7.1 0.0 21 45 226 250 222 254 0.90

6 8 0.0024 1.1 10.3 0.1 21 46 254 279 250 285 0.86

7 8 1.5 6.8e+02 1.3 0.1 21 31 282 292 278 310 0.78

8 8 0.0054 2.4 9.2 0.2 21 45 310 334 302 337 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.2	88	4.2	0.0	21	45	114	138	108	142	0.88
2	8	0.0052	2.3	9.2	0.2	21	52	142	173	138	174	0.86
3	8	0.84	3.8e+02	2.1	0.1	22	45	171	194	168	197	0.86
4	8	0.12	54	4.9	0.1	21	46	198	223	194	230	0.83
5	8	0.025	11	7.1	0.0	21	45	226	250	222	254	0.90
6	8	0.0024	1.1	10.3	0.1	21	46	254	279	250	285	0.86
7	8	1.5	6.8e+02	1.3	0.1	21	31	282	292	278	310	0.78
8	8	0.0054	2.4	9.2	0.2	21	45	310	334	302	337	0.88

Coding Sequence: ATGGAACGGATCGACCAAGTATCGGAACCTCCCGATAATTTTAGTAGCCATGAAATTAAAGTAGAAGATGTGAAGTTTAATTTAGAAGATTTACATCACTCGATAGACATCAAAGACGAGAGCGAGAGCGATGCTGAACAACTACCACTGCAGAAACCCGTAAGAAAAACTAAAAACTCAAATTTTATTTGTCAGTTTTGTGATTATAAATGTGCATGGAAATCAAATTTAATAATACATTTAAAAACTCACACAGGTGAGAAATCTTTTGCTTGTGAGATTTGTGATTATAAATTCGCACGAAGAACAACTTTAATAGATCATTTAAAAACTCACACAGGCGAGAAACCTTTTGCTTGTGAGATTTGTGACTATAAATGTGCACAAAAAGGAGCTTTAAAAGAACATTTAAGAACTCACACAGGCGAGAAACCTTTTGCTTGTGAGATTTGTGACTATAAATGTGCACAAAGAGGAGCTTTAAAAAGACATTTAAGAATTCACACAGGCGATAAACCTTTTGCTTGTGAAATTTGTGACTATAAATGTGCACAAAAAACATCTTTAAAATTACATTTAAGAACTCACACAGGCGAGAAACCTTTTGCTTGTGAGATTTGTGACTATAAATGTGCACAAAGAGCATCTTTAAAAGACCATTTAAGAACGCACACAGGCGAGAAACCTTTTGTTTGTGAGATTTGTGACTATAAATCTGCACAAAAAACAAATTTAAAAGAACATTTAAGAACTCACACAGGCGAGAAACCTTTTGCTTGCGAGATTTGTGACTATAAATGTGCACAAAAAACAAATTTAAAAAAACATTTAACAACTCACACAGGTGAAAAACCCATTGCTTGTGATATTTGTAACTATAAATTTGCAGAAAGAATAAAGTTAAAAATTCATGTAAGAACACACACAGGCGAGAAACCTTTTGCTTGTGAGATATGTGATTATAAATGTGTTCAAAATAGATCTTTAAAACATCATTTAAAAAGTCACAATGCATGA
Protein Sequence: MERIDQVSEPPDNFSSHEIKVEDVKFNLEDLHHSIDIKDESESDAEQLPLQKPVRKTKNSNFICQFCDYKCAWKSNLIIHLKTHTGEKSFACEICDYKFARRTTLIDHLKTHTGEKPFACEICDYKCAQKGALKEHLRTHTGEKPFACEICDYKCAQRGALKRHLRIHTGDKPFACEICDYKCAQKTSLKLHLRTHTGEKPFACEICDYKCAQRASLKDHLRTHTGEKPFVCEICDYKSAQKTNLKEHLRTHTGEKPFACEICDYKCAQKTNLKKHLTTHTGEKPIACDICNYKFAERIKLKIHVRTHTGEKPFACEICDYKCVQNRSLKHHLKSHNA

Sequence clustering based on sequence similarity using MMseqs2