Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.19 84 4.3 0.1 21 45 86 110 80 113 0.86

2 8 0.00037 0.17 12.9 0.1 21 47 114 140 110 146 0.85

3 8 1.2 5.3e+02 1.7 0.1 21 44 142 165 138 173 0.71

4 8 0.12 54 4.9 0.1 21 48 170 197 161 201 0.76

5 8 0.27 1.2e+02 3.7 0.1 21 46 198 223 194 229 0.82

6 8 0.11 48 5.0 0.2 21 45 226 250 222 253 0.86

7 8 0.12 53 4.9 0.2 21 45 254 278 250 281 0.86

8 8 0.0037 1.7 9.7 0.0 21 45 282 306 278 309 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.19	84	4.3	0.1	21	45	86	110	80	113	0.86
2	8	0.00037	0.17	12.9	0.1	21	47	114	140	110	146	0.85
3	8	1.2	5.3e+02	1.7	0.1	21	44	142	165	138	173	0.71
4	8	0.12	54	4.9	0.1	21	48	170	197	161	201	0.76
5	8	0.27	1.2e+02	3.7	0.1	21	46	198	223	194	229	0.82
6	8	0.11	48	5.0	0.2	21	45	226	250	222	253	0.86
7	8	0.12	53	4.9	0.2	21	45	254	278	250	281	0.86
8	8	0.0037	1.7	9.7	0.0	21	45	282	306	278	309	0.91

Coding Sequence: ATGGAACGAATCGACCAAGTATCGGAACCTTCCGATAATTCTAGTAGCTGTGAAATTAAGGTAGAAGATGTGAAGTTTAATTTAGAAGATTTACATCACTCGATAGACATCAAAGACGAGTTCGAAAGTGATGCAGAACAACTAGCACTGGAGAAACCCGTAAGAAAAACTAAAAACTCAAATTTTATATGTCAGTTTTGTGATTATAAATGTGCAGCGAAATCAGTATTAAAAATACATTTAAGAACTCACACAGGTGAAAAACCTTTTTTTTGTGATATTTGTGACTATAAATGTGCAGAAAGAACATCTTTAAGAAAACATTTAAGAACCCACACAGGTGAGAAACCTTTTGCTTGTGATATTTGTGATTATAAATTTGCACAAAGGTCAAATTTAAAAAGACATTTAAGAACTCACACAGGCGAGAAACCTTTTGCTTGTGAGATTTGTGACTATAAATCTGCTACAAGAGAACATTTAAAAGAACATTTAAGAACTCACACAGGTGAAAAACCTTTTGCGTGTGAGATTTGTGACTATAAAAGTGCACTAAGGGGACATTTAAAAAGACATTTAAGAATTCACACAGGCGAGAAACCTTTTTCTTGTAAGATTTGTGACTATAAATCTTCACATAGAGTAAATTTAAAGGTACATTTAAAAACTCACACAGGTGAAAAGCCTTTTTCTTGTGATATTTGTGACTATAAATGTGCAGAAAGAGCATCTTTAAGAAAACATTTAAGAACTCACACAGGCGAGAAACCTTTTGTTTGTGAGATTTGCGAGTATAAATGTGCACTGAGAGAAAATTTAAAAAAACATTTAAGAACTCACACAGGCGAGAAACCTTTTGCTTGTGAGATTTGTGATTATAAATTTGCTCAAAATAGATCTTTAAAACATCATTTAAAAAGTCACAATGCATAG
Protein Sequence: MERIDQVSEPSDNSSSCEIKVEDVKFNLEDLHHSIDIKDEFESDAEQLALEKPVRKTKNSNFICQFCDYKCAAKSVLKIHLRTHTGEKPFFCDICDYKCAERTSLRKHLRTHTGEKPFACDICDYKFAQRSNLKRHLRTHTGEKPFACEICDYKSATREHLKEHLRTHTGEKPFACEICDYKSALRGHLKRHLRIHTGEKPFSCKICDYKSSHRVNLKVHLKTHTGEKPFSCDICDYKCAERASLRKHLRTHTGEKPFVCEICEYKCALRENLKKHLRTHTGEKPFACEICDYKFAQNRSLKHHLKSHNA

Sequence clustering based on sequence similarity using MMseqs2