Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.25 1.1e+02 3.8 0.2 21 46 104 129 98 135 0.84

2 8 0.052 23 6.0 0.0 21 46 132 157 128 163 0.84

3 8 0.36 1.6e+02 3.3 0.1 21 45 160 184 156 187 0.73

4 8 0.03 13 6.8 0.0 21 45 188 212 184 216 0.85

5 8 0.0074 3.3 8.7 0.1 21 46 216 241 213 247 0.86

6 8 0.017 7.7 7.6 0.1 21 46 244 269 240 275 0.78

7 8 0.016 7.4 7.6 0.1 21 45 272 296 268 300 0.91

8 8 0.067 30 5.7 0.3 22 45 301 324 296 327 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.25	1.1e+02	3.8	0.2	21	46	104	129	98	135	0.84
2	8	0.052	23	6.0	0.0	21	46	132	157	128	163	0.84
3	8	0.36	1.6e+02	3.3	0.1	21	45	160	184	156	187	0.73
4	8	0.03	13	6.8	0.0	21	45	188	212	184	216	0.85
5	8	0.0074	3.3	8.7	0.1	21	46	216	241	213	247	0.86
6	8	0.017	7.7	7.6	0.1	21	46	244	269	240	275	0.78
7	8	0.016	7.4	7.6	0.1	21	45	272	296	268	300	0.91
8	8	0.067	30	5.7	0.3	22	45	301	324	296	327	0.88

Coding Sequence: ATGAACATTAGCCACAGTTACACTTCAAAAAATATTATCGAAGAGTTAGAAATTATGGAACGAATCGATGAAGTGTCAGAACATCCTGATAATTCTAGTAGCCGTGAAATTAAAGTAGAAGATGTGAAGTTTAATTTAGAAGATTTACATCACTCGATAGACATTAAAGAAGAGAGCGAGAGCGATGCAGAACAACTAGCACTGGAGAAACCCGTAAGAAAAACTAAAAACTCAAATTTTATTTGTCAGTTTTGTGATTATAAATGTGCATGGAAATCAGTATTAATAAGACATTTAAGAACTCACACAGGCGAGAAACCGTTTTTTTGTGAGATTTGTAACTATAAATGTGCACAAAGAGAATCTTTAAAAATACATTTAAGAACTCACACAGGCGAGAAACCATTTGCTTGTGAGATTTGTAACTATAAAAGTGTAGAAAGTACAACTTTAAAAAAACATTTAAGAACTCACACAGGCGAGAAACCTTTTTTTTGTGAGATTTGTAACTATAGAAGTGCTCGAAAATTAGTTTTAAAAAGACATTTAAAAACTCACACAGGCGAGAAACCTTTTACTTGTGATATTTGTGACTATAAATGTGTACAAAGAGGACATTTAAAAGAACATTTAAAAACTCACACAGGTGAGAAACCTTATGCTTGTAAGATTTGTGTCTATAAATGCTCACAAAAAGGAGGTTTAAAAAGACATTTAAGAACTCACACAGGTGAAAAACCTTTTACTTGTGAGATTTGTGACTATAAATGTATACAAAGAGGACATTTAAAAGAACATTTAAAAACTCACACAGGTGAGAAACCTTATGCTTGTAAGGTTTGTGTCTATAAATGCGCACAAAAAGGAGATTTAAAAAGACATTTAAGAACTCACACAGGTGAAAAATCTTTTGCTTGTGAGATCTGTGATTATAAATGTGCTCAAAATAGATCTTTAAAACATCATTTAAAAAGTCACAACGCATAG
Protein Sequence: MNISHSYTSKNIIEELEIMERIDEVSEHPDNSSSREIKVEDVKFNLEDLHHSIDIKEESESDAEQLALEKPVRKTKNSNFICQFCDYKCAWKSVLIRHLRTHTGEKPFFCEICNYKCAQRESLKIHLRTHTGEKPFACEICNYKSVESTTLKKHLRTHTGEKPFFCEICNYRSARKLVLKRHLKTHTGEKPFTCDICDYKCVQRGHLKEHLKTHTGEKPYACKICVYKCSQKGGLKRHLRTHTGEKPFTCEICDYKCIQRGHLKEHLKTHTGEKPYACKVCVYKCAQKGDLKRHLRTHTGEKSFACEICDYKCAQNRSLKHHLKSHNA

Sequence clustering based on sequence similarity using MMseqs2