Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.074 33 5.5 0.1 25 45 77 97 70 103 0.86

2 7 4.8 2.2e+03 -0.3 0.1 25 44 105 124 97 132 0.65

3 7 0.14 62 4.7 0.1 21 46 129 154 117 160 0.83

4 7 0.087 39 5.3 0.0 21 45 157 181 153 184 0.87

5 7 0.17 75 4.4 0.1 21 44 185 208 181 212 0.72

6 7 7.5e-05 0.034 15.1 0.2 20 45 212 237 202 240 0.87

7 7 0.02 9.1 7.3 0.0 21 45 241 265 237 268 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.074	33	5.5	0.1	25	45	77	97	70	103	0.86
2	7	4.8	2.2e+03	-0.3	0.1	25	44	105	124	97	132	0.65
3	7	0.14	62	4.7	0.1	21	46	129	154	117	160	0.83
4	7	0.087	39	5.3	0.0	21	45	157	181	153	184	0.87
5	7	0.17	75	4.4	0.1	21	44	185	208	181	212	0.72
6	7	7.5e-05	0.034	15.1	0.2	20	45	212	237	202	240	0.87
7	7	0.02	9.1	7.3	0.0	21	45	241	265	237	268	0.91

Coding Sequence: ATGGAAACCATCGGTGAAGTTATGGAAACTCCGGCTGACTCCAGTAGCAGTTCCATTGTTAAAATAGAAGAATTGGAAGACGTCAAAATAGAAGATTTGCATCATTCGATTGACATTAAAGAAGAGAGTGCTCATGAACCATTAATACAGGAAAAATGTGCATATAAAAACTCAAATTTTAAATTTGCAATAAAACTGCAGATGAAAACTCCCACAGGTGAAAAACTGCTTAAATGCAAAGTTTGCGACTTTAAATGTTCACAAAAATCAGATTTAAGAAGGCATTTAAAAAGTCACACTCGTAATAAATGGTTTACTTGCGAAATTTGTAACTACAAGTTTGTAAAACCATCGATACTAAAACTACATTTACGAACGCACACCGGTGAGAAACCATTTAATTGTGATATTTGTGACTATAAATGTGCGCACAAACCAAATTTAAAAATTCATTTAAAAACTCACAGCGGAGAAAAACCATTTGCTTGTGAAATTTGTGATTATAAATGCGCAAAAAAATTTAACTTAAAAACGCATTTAAAAAGTCACACCGGCGAAAAGCCATTTACATGTGAAATTTGTAACTACGAAAGTGCGCTGAAGACAGATTTAGAAAAGCATTTGAAAACTCATACTGGTGAGAAACCGTATACTTGTGAAATTTGTGATTATAAGTGCGCACAGAAGCCAAATTTAAAAAGGCATTTGCAAACCCATACCGGAGAAAAGCCTTTTGCTTGTGAAGTGTGCAATTATAAATTTTCCCTTAAAAGGAATTTAAAAACGCATTTGAAAACTCATACCAATTAG
Protein Sequence: METIGEVMETPADSSSSSIVKIEELEDVKIEDLHHSIDIKEESAHEPLIQEKCAYKNSNFKFAIKLQMKTPTGEKLLKCKVCDFKCSQKSDLRRHLKSHTRNKWFTCEICNYKFVKPSILKLHLRTHTGEKPFNCDICDYKCAHKPNLKIHLKTHSGEKPFACEICDYKCAKKFNLKTHLKSHTGEKPFTCEICNYESALKTDLEKHLKTHTGEKPYTCEICDYKCAQKPNLKRHLQTHTGEKPFACEVCNYKFSLKRNLKTHLKTHTN

Sequence clustering based on sequence similarity using MMseqs2