Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.11 50 5.0 0.0 19 44 45 71 41 76 0.85

2 6 1.1 5.2e+02 1.7 0.0 21 46 76 101 74 105 0.89

3 6 0.27 1.2e+02 3.7 0.5 26 44 137 155 128 160 0.82

4 6 9.8e-06 0.0044 18.0 0.3 21 46 160 185 158 190 0.91

5 6 5.9e-05 0.026 15.5 0.1 21 46 222 247 216 253 0.86

6 6 0.46 2.1e+02 3.0 0.1 19 44 249 273 246 279 0.66

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.11	50	5.0	0.0	19	44	45	71	41	76	0.85
2	6	1.1	5.2e+02	1.7	0.0	21	46	76	101	74	105	0.89
3	6	0.27	1.2e+02	3.7	0.5	26	44	137	155	128	160	0.82
4	6	9.8e-06	0.0044	18.0	0.3	21	46	160	185	158	190	0.91
5	6	5.9e-05	0.026	15.5	0.1	21	46	222	247	216	253	0.86
6	6	0.46	2.1e+02	3.0	0.1	19	44	249	273	246	279	0.66

Coding Sequence: ATGGAAGATGAACGTCCTACCGATGAAATATCAGATTTTGGAGTGTTTGATTTGAAAATAAAAATAGAAGAAGAAGAAGAGATCAAATCAGACCCTTTAGACTACTTTTTTGACGTTCAGTCGTATATAAATTCTCAAGAAGAACAAAAACCATTTGCTTGTGGACTTTGTGAGTACAGAACGACGAAGAAGGGAAATCTGCAACGACACGAAAAGATCCACACCGGAGAAAGACCATTTGCATGTATACTTTGTGATTCTAAATTTAAAGAAAACAGTGCGTTACAGAAACATTTTAAAATACACACCGGTAAGGATTCATTTAAGTGCGAAGTTTGTAGCAATAATTTTTCCACCAAGGGTTCGTTAAAACTACATCTCAAGATTCACTCTGGGGAGAGGTTATTCAAGTGTGAATTTTGCGATTACAGAGCCATAAGGCAAAGTCACTTACGGAGTCATTTATTGGTTCACACAAACGAAAAGCCATTTGTTTGTGAAATCTGTCACTATGCGACCAGAAGTTCGACAAATTTACAAAGACATTTAAAGATTCATGTAGATAAAAGTTTAATTTCGATTGAAAAACCATATCAGTGTGAAACTTGCGATTACAAAACTGCGGATAAAAGTTACTTTTTACAGCATTCCAAAATTCATACTGGAGAAAAACCGTTTTCTTGTTATATTTGTGATTATGCGACTCTAAGGAGCCGAGATTTAAAAAGACACTTAAAAATTCACTCGAAAGACGAACAATATGAATGTGCAAGTTGTGGTTATAAAACGGTGGACAAAAGTAACTTACGACGGCATATAATTAAAAAGTTAACTCATTCTAAATGA
Protein Sequence: MEDERPTDEISDFGVFDLKIKIEEEEEIKSDPLDYFFDVQSYINSQEEQKPFACGLCEYRTTKKGNLQRHEKIHTGERPFACILCDSKFKENSALQKHFKIHTGKDSFKCEVCSNNFSTKGSLKLHLKIHSGERLFKCEFCDYRAIRQSHLRSHLLVHTNEKPFVCEICHYATRSSTNLQRHLKIHVDKSLISIEKPYQCETCDYKTADKSYFLQHSKIHTGEKPFSCYICDYATLRSRDLKRHLKIHSKDEQYECASCGYKTVDKSNLRRHIIKKLTHSK

Sequence clustering based on sequence similarity using MMseqs2