Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0039 1.8 9.6 0.0 21 44 111 134 107 140 0.90

2 7 1.1 4.9e+02 1.8 0.6 22 43 140 161 136 166 0.83

3 7 0.012 5.6 8.0 0.6 21 45 167 191 159 198 0.83

4 7 2 8.9e+02 1.0 0.1 25 48 199 222 192 227 0.72

5 7 2e-05 0.0092 16.9 0.0 21 52 248 279 239 281 0.88

6 7 0.018 8.1 7.5 0.0 21 45 304 328 298 331 0.79

7 7 0.1 45 5.1 0.1 21 46 332 357 329 359 0.79

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0039	1.8	9.6	0.0	21	44	111	134	107	140	0.90
2	7	1.1	4.9e+02	1.8	0.6	22	43	140	161	136	166	0.83
3	7	0.012	5.6	8.0	0.6	21	45	167	191	159	198	0.83
4	7	2	8.9e+02	1.0	0.1	25	48	199	222	192	227	0.72
5	7	2e-05	0.0092	16.9	0.0	21	52	248	279	239	281	0.88
6	7	0.018	8.1	7.5	0.0	21	45	304	328	298	331	0.79
7	7	0.1	45	5.1	0.1	21	46	332	357	329	359	0.79

Coding Sequence: ATGGATAAACCGTCACCTTTGCAAGACTTTCAGAAGAACGAAAACGATAATAATTACCAAATTAAAACAGAAAAATTTGAAAGCGTAGACATTAAAATAGAAGATTTGTATATTAAAGAAGAGGATGTTTCGATTGAGGGCTGCGATTTGGTTATTAAAGACGAAGACGTTTCGATTGAAGAGCATCCGCTAGATATTAGTGAAGTTAAATTACCCTATCAGGCGCATTTCGAGCAAGGCGGTGCCGGAGAAAAACGTTTCTCTTGTGAAATTTGTGGTTATAAGTGCAAACGAAGAAATGTCTTAAAATACCATTTAAGAATTCATACTGGCGAAAAACCGTTTACATGTGAAATTTGCGGTTATAAATTTTCACAAAAAATAAATTTAAAAACACATTTGCTAACCCACACAGGCGAGAAATCGTTAACGTGTAAAATCTGTAACTATAAATGCGCACAAATCGGAAGGTTAAGAGCCCATCACAGAACTCATACAGGCGAGAAGCCCTTCACATGTGAAATTTGTAACTACAAATGTGCACGTAAGGAGAACTTAAAAATTCACTTACGAACTCACACCGGCGAAAAGCGATTTGCTTGTCAGTTTTGTGACTACAAATGTTTAGAAAAAGGAAATTTAAACAGACATTTAAAAACCCACACTGGGCAAAAGCCGTTCAAGTGCGGAATTTGCGGATTGGAATGCAGCAATTTAAAAACTCATTTACGAACCCATACGGGCGAAAAACCGTTCACATGTGAAATTTGTGGTTATAAAACTAAGGAAAGTGGAAATTTAAACCGGCATTTGAAAATTCATTCAGATGATAAACCGTTCGTATGTGAATTTTGTAATTACAAATGTGCTCATAGGGATCGTTTCGTAATTCATTTACGAAGTCACACTGGTGAAAAACCATTTGCATGTGGAATTTGTGATTACAGATGCATTCAAAAGGGAAAATTAAACCGGCACTTAAAAACGCATACTGGCGAAAAGCCGTTTAGTTGTGACTTTTGCGACTATAAATGCATACAAAAATCAAGTTTAACTAGGCATTTAAAAATTCATACCGAATAA
Protein Sequence: MDKPSPLQDFQKNENDNNYQIKTEKFESVDIKIEDLYIKEEDVSIEGCDLVIKDEDVSIEEHPLDISEVKLPYQAHFEQGGAGEKRFSCEICGYKCKRRNVLKYHLRIHTGEKPFTCEICGYKFSQKINLKTHLLTHTGEKSLTCKICNYKCAQIGRLRAHHRTHTGEKPFTCEICNYKCARKENLKIHLRTHTGEKRFACQFCDYKCLEKGNLNRHLKTHTGQKPFKCGICGLECSNLKTHLRTHTGEKPFTCEICGYKTKESGNLNRHLKIHSDDKPFVCEFCNYKCAHRDRFVIHLRSHTGEKPFACGICDYRCIQKGKLNRHLKTHTGEKPFSCDFCDYKCIQKSSLTRHLKIHTE

Sequence clustering based on sequence similarity using MMseqs2