Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.019 8.4 7.4 0.1 17 45 68 97 64 100 0.85

2 9 0.002 0.91 10.5 0.0 21 52 101 132 97 134 0.88

3 9 2 9.2e+02 0.9 0.1 21 43 129 151 127 155 0.73

4 9 0.095 43 5.2 0.2 21 44 157 180 151 188 0.86

5 9 0.0089 4 8.5 0.1 23 52 187 216 181 218 0.83

6 9 0.15 69 4.5 0.0 21 46 213 238 209 244 0.85

7 9 0.17 78 4.4 0.0 21 49 241 269 237 272 0.86

8 9 0.4 1.8e+02 3.2 0.1 21 45 269 293 266 296 0.82

9 9 0.0014 0.61 11.1 0.3 21 45 297 321 293 325 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.019	8.4	7.4	0.1	17	45	68	97	64	100	0.85
2	9	0.002	0.91	10.5	0.0	21	52	101	132	97	134	0.88
3	9	2	9.2e+02	0.9	0.1	21	43	129	151	127	155	0.73
4	9	0.095	43	5.2	0.2	21	44	157	180	151	188	0.86
5	9	0.0089	4	8.5	0.1	23	52	187	216	181	218	0.83
6	9	0.15	69	4.5	0.0	21	46	213	238	209	244	0.85
7	9	0.17	78	4.4	0.0	21	49	241	269	237	272	0.86
8	9	0.4	1.8e+02	3.2	0.1	21	45	269	293	266	296	0.82
9	9	0.0014	0.61	11.1	0.3	21	45	297	321	293	325	0.83

Coding Sequence: ATGGAAAACAACGGACTAGTTTACAATAACCAAATTGAAATCAAAAAGGAAGATTTGGAAGATGTAAAATTTCAGTTGGAAAGTTTACATCACACAATTGACATTAAGGAGGAAAACTACGTTGAACAATTAACACAGGAGGAACCTGGAATCAAATGTAATTTATTCGAGTGCAGTTGCGACTTTGAATGCGCCCATAAAGCGAGGGCTCAAACCGGCAAAAAACCATTTATTTGTGAACTTTGCAACTCGAAATTTGCACATTCAGCAAGTTTAAAAAGGCATTTGAAATCTCATACGGGCGAAAAACCGTTTGCTTGTGGAATTTGTGACTATAAAAGCGCGCAAATGAGTAATTTACAATCGCATTTAAAACTTCACACCGGCGAAAAACCATTTATCTGTGAAATTTGTGGCTACAAATGTTCGCATAAGTCAAATTTAAATTTGCACGTAAGAACTCACACACGCGAGAAACCGTTTTCTTGTGAAATTTGTAACCATAAATGTGCAAATAGTTCAGCGTTAAAAACTCATTTAATATCTCATTCCGACGTAAAACCGTTTTCGTGTGAAATTTGTGACCATAAATGTGCACAAAAATCGGATTTAAAAAGGCATTTACGCACTCACACCGGAGAGAAACCTTTTGTTTGTAAAATTTGTGACCAAAAATTTACACAAATAGCAAGTTTAAAACAGCACGTAAAAACTCACACCGGCGAAAAACCATATTTTTGTGAAATTTGTGACCGTAAGTTTTCACATGTAACGAGTTTAAAAAGGCACGTGAAAATTCACACCGGGGAAAAACCGTTTGCTTGTGTGTTTTGTGACTATAAAAGTGCACGGAGCTCGCATTTAAAAAGGCACATCAACAGCCACGCAGGCGAGAAACCTTTTTCTTGTGGAATTTGTAATTGTAGATATACACGGCAATCGAATTTAAAAAGGCATTTAAAAACTCACACTGTTGGATGA
Protein Sequence: MENNGLVYNNQIEIKKEDLEDVKFQLESLHHTIDIKEENYVEQLTQEEPGIKCNLFECSCDFECAHKARAQTGKKPFICELCNSKFAHSASLKRHLKSHTGEKPFACGICDYKSAQMSNLQSHLKLHTGEKPFICEICGYKCSHKSNLNLHVRTHTREKPFSCEICNHKCANSSALKTHLISHSDVKPFSCEICDHKCAQKSDLKRHLRTHTGEKPFVCKICDQKFTQIASLKQHVKTHTGEKPYFCEICDRKFSHVTSLKRHVKIHTGEKPFACVFCDYKSARSSHLKRHINSHAGEKPFSCGICNCRYTRQSNLKRHLKTHTVG

Sequence clustering based on sequence similarity using MMseqs2